Mapping of solution components, pH changes, protein stability and the elimination of protein precipitation during freeze-thawing of fibroblast growth factor 20

International Journal of Pharmaceutics

Volumn 378, Issue 1-2, 2009, Pages 122-135

  Maity, Haripada ^a   Karkaria, Cyrus ^a   Davagnino, Juan ^a  

^a CURAGEN CORPORATION   (United States)

Author keywords

Aggregation; Arginine; Circular dichroism; Differential scanning calorimetry; Fibroblast growth factor; Fluorescence; Folding unfolding; Protein solubility; Protein stability; Salting out; Thermodynamics

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ARGININE; CITRIC ACID; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 20; HISTIDINE; POLYSORBATE 80; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; FREEZE THAWING; PH; PHASE SEPARATION; PRECIPITATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; TEMPERATURE DEPENDENCE; THERMOSTABILITY;

BUFFERS; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; FIBROBLAST GROWTH FACTORS; FREEZING; HYDROGEN-ION CONCENTRATION; POLYSORBATES; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STABILITY; SURFACE-ACTIVE AGENTS; TEMPERATURE; TIME FACTORS;

EID: 67650591002     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.05.063     Document Type: Article

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