Trichodysplasia spinulosa-Associated Polyomavirus (TSV) and Merkel Cell Polyomavirus: Correlation between Humoral and Cellular Immunity Stronger with TSV

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Kumar, Arun ^a   Kantele, Anu ^a,b,c   Järvinen, Tommi ^a   Chen, Tingting ^a   Kavola, Heli ^c   Sadeghi, Mohammadreza ^a   Hedman, Klaus ^a,c   Franssila, Rauli ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13;

ADULT; ANTIBODY RESPONSE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMORAL IMMUNITY; LYMPHOCYTE; MALE; MERKEL CELL POLYOMAVIRUS; NONHUMAN; NORMAL HUMAN; POLYMERASE CHAIN REACTION; POLYOMA VIRUS; REGULATORY T LYMPHOCYTE; SEQUENCE HOMOLOGY; T LYMPHOCYTE; TRICHODYSPLASIA SPINULOSA ASSOCIATED POLYOMAVIRUS; VIRUS LIKE AGENT;

ADULT; ANTIGENS, FUNGAL; ANTIGENS, VIRAL; CANDIDA ALBICANS; CAPSID PROTEINS; CARCINOMA, MERKEL CELL; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-10; MALE; MERKEL CELL POLYOMAVIRUS; MIDDLE AGED; POLYOMAVIRUS INFECTIONS; T-LYMPHOCYTES, HELPER-INDUCER; TUMOR VIRUS INFECTIONS; VIRUS REPLICATION; YOUNG ADULT;

POLYOMAVIRUS;

EID: 84866648367     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045773     Document Type: Article

References (59)

1. Feng H, Shuda M, Chang Y, Moore PS, (2008) Clonal integration of a polyomavirus in human merkel cell carcinoma. Science 319: 1096-1100.
2. Shuda M, Feng H, Kwun HJ, Rosen ST, Gjoerup O, et al. (2008) T antigen mutations are a human tumor-specific signature for merkel cell polyomavirus. Proc Natl Acad Sci U S A 105: 16272-16277.
3. Foulongne V, Kluger N, Dereure O, Brieu N, Guillot B, et al. (2008) Merkel cell polyomavirus and merkel cell carcinoma, france. Emerg Infect Dis 14: 1491-1493.
4. Becker JC, Houben R, Ugurel S, Trefzer U, Pfohler C, et al. (2009) MC polyomavirus is frequently present in merkel cell carcinoma of european patients. J Invest Dermatol 129: 248-250.
5. Garneski KM, Warcola AH, Feng Q, Kiviat NB, Leonard JH, et al. (2009) Merkel cell polyomavirus is more frequently present in north american than australian merkel cell carcinoma tumors. J Invest Dermatol 129: 246-248.
6. Paolini F, Donati P, Amantea A, Bucher S, Migliano E, et al. (2011) Merkel cell polyomavirus in merkel cell carcinoma of italian patients. Virol J 8: 103.
7. Jung HS, Choi YL, Choi JS, Roh JH, Pyon JK, et al. (2011) Detection of merkel cell polyomavirus in merkel cell carcinomas and small cell carcinomas by PCR and immunohistochemistry. Histol Histopathol 26: 1231-1241.
8. Sihto H, Kukko H, Koljonen V, Sankila R, Bohling T, et al. (2009) Clinical factors associated with merkel cell polyomavirus infection in merkel cell carcinoma. J Natl Cancer Inst 101: 938-945.
9. Kean JM, Rao S, Wang M, Garcea RL, (2009) Seroepidemiology of human polyomaviruses. PLoS Pathog 5: e1000363.
10. Tolstov YL, Pastrana DV, Feng H, Becker JC, Jenkins FJ, et al. (2009) Human merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer 125: 1250-1256.
11. Touze A, Le Bidre E, Laude H, Fleury MJ, Cazal R, et al. (2011) High levels of antibodies against merkel cell polyomavirus identify a subset of patients with merkel cell carcinoma with better clinical outcome. J Clin Oncol 29: 1612-1619.
12. Carter JJ, Paulson KG, Wipf GC, Miranda D, Madeleine MM, et al. (2009) Association of merkel cell polyomavirus-specific antibodies with merkel cell carcinoma. J Natl Cancer Inst 101: 1510-1522.
13. Schowalter RM, Pastrana DV, Pumphrey KA, Moyer AL, Buck CB, (2010) Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. Cell Host Microbe 7: 509-515.
14. van der Meijden E, Janssens RW, Lauber C, Bouwes Bavinck JN, Gorbalenya AE, et al. (2010) Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. PLoS Pathog 6: e1001024.
15. Haycox CL, Kim S, Fleckman P, Smith LT, Piepkorn M, et al. (1999) Trichodysplasia spinulosa-a newly described folliculocentric viral infection in an immunocompromised host. J Investig Dermatol Symp Proc 4: 268-271.
16. Wyatt AJ, Sachs DL, Shia J, Delgado R, Busam KJ, (2005) Virus-associated trichodysplasia spinulosa. Am J Surg Pathol 29: 241-246.
17. Tan BH, Busam KJ, (2011) Virus-associated trichodysplasia spinulosa. Adv Anat Pathol 18(6): 450-453.
18. Matthews MR, Wang RC, Reddick RL, Saldivar VA, Browning JC, (2011) Viral-associated trichodysplasia spinulosa: A case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus. J Cutan Pathol 38: 420-431.
19. Moens U, Ludvigsen M, Van Ghelue M, (2011) Human polyomaviruses in skin diseases. Patholog Res Int 2011: 123491.
20. Kazem S, van der Meijden E, Kooijman S, Rosenberg AS, Hughey LC, et al. (2012) Trichodysplasia spinulosa is characterized by active polyomavirus infection. J Clin Virol 53: 225-230.
21. van der Meijden E, Kazem S, Burgers MM, Janssens R, Bouwes Bavinck JN, et al. (2011) Seroprevalence of trichodysplasia spinulosa-associated polyomavirus. Emerg Infect Dis 17: 1355-1363.
22. Chen T, Mattila PS, Jartti T, Ruuskanen O, Soderlund-Venermo M, et al. (2011) Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus. J Infect Dis 204: 1523-1526.
23. Zhu J, Paul WE, (2008) CD4 T cells: Fates, functions, and faults. Blood 112: 1557-1569.
24. Swain SL, McKinstry KK, Strutt TM, (2012) Expanding roles for CD4(+) T cells in immunity to viruses. Nat Rev Immunol 12: 136-148.
25. Kumar A, Chen T, Pakkanen S, Kantele A, Soderlund-Venermo M, et al. (2011) T-helper cell-mediated proliferation and cytokine responses against recombinant merkel cell polyomavirus-like particles. PLoS One 6: e25751.
26. Iyer JG, Afanasiev OK, McClurkan C, Paulson K, Nagase K, et al. (2011) Merkel cell polyomavirus-specific CD8 and CD4 T-cell responses identified in merkel cell carcinomas and blood. Clin Cancer Res 17: 6671-6680.
27. Tannenbaum CS, Hamilton TA, (2000) Immune-inflammatory mechanisms in IFNgamma-mediated anti-tumor activity. Semin Cancer Biol 10: 113-123.
28. Boehm U, Klamp T, Groot M, Howard JC, (1997) Cellular responses to interferon-gamma. Annu Rev Immunol 15: 749-795.
29. Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, et al. (1998) Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A 95: 7556-7561.
30. Kornacker M, Moldenhauer G, Herbst M, Weilguni E, Tita-Nwa F, et al. (2006) Cytokine-induced killer cells against autologous CLL: Direct cytotoxic effects and induction of immune accessory molecules by interferon-gamma. Int J Cancer 119: 1377-1382.
31. Beatty GL, Paterson Y, (2001) Regulation of tumor growth by IFN-gamma in cancer immunotherapy. Immunol Res 24: 201-210.
32. Willmes C, Adam C, Alb M, Volkert L, Houben R, et al. (2012) Type I and II IFNs inhibit merkel cell carcinoma via modulation of the merkel cell polyomavirus T antigens. Cancer Res 72: 2120-2128.
33. Couper KN, Blount DG, Riley EM, (2008) IL-10: The master regulator of immunity to infection. J Immunol 180: 5771-5777.
34. Mosser DM, Zhang X, (2008) Interleukin-10: New perspectives on an old cytokine. Immunol Rev 226: 205-218.
35. Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, et al. (1992) Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 89: 1890-1893.
36. McKenzie AN, Culpepper JA, de Waal Malefyt R, Briere F, Punnonen J, et al. (1993) Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc Natl Acad Sci U S A 90: 3735-3739.
37. Wynn TA, (2003) IL-13 effector functions. Annu Rev Immunol 21: 425-456.
38. Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, et al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A 90: 3730-3734.
39. Kapp U, Yeh WC, Patterson B, Elia AJ, Kagi D, et al. (1999) Interleukin 13 is secreted by and stimulates the growth of hodgkin and reed-sternberg cells. J Exp Med 189: 1939-1946.
40. Terabe M, Park JM, Berzofsky JA, (2004) Role of IL-13 in regulation of anti-tumor immunity and tumor growth. Cancer Immunol Immunother 53: 79-85.
41. Ma HL, Whitters MJ, Jacobson BA, Donaldson DD, Collins M, et al. (2004) Tumor cells secreting IL-13 but not IL-13Ralpha2 fusion protein have reduced tumorigenicity in vivo. Int Immunol 16: 1009-1017.
42. Sadeghi M, Riipinen A, Vaisanen E, Chen T, Kantola K, et al. (2010) Newly discovered KI, WU, and merkel cell polyomaviruses: No evidence of mother-to-fetus transmission. Virol J 7: 251.
43. Chen T, Hedman L, Mattila PS, Jartti T, Ruuskanen O, et al. (2011) Serological evidence of merkel cell polyomavirus primary infections in childhood. J Clin Virol 50: 125-129.
44. Franssila R, Hokynar K, Hedman K, (2001) T helper cell-mediated in vitro responses of recently and remotely infected subjects to a candidate recombinant vaccine for human parvovirus b19. J Infect Dis 183: 805-809.
45. Kumar A, Filippone C, Lahtinen A, Hedman L, Soderlund-Venermo M, et al. (2011) Comparison of th-cell immunity against human bocavirus and parvovirus B19: Proliferation and cytokine responses are similar in magnitude but more closely interrelated with human bocavirus. Scand J Immunol 73: 135-140.
46. Pastrana DV, Tolstov YL, Becker JC, Moore PS, Chang Y, et al. (2009) Quantitation of human seroresponsiveness to merkel cell polyomavirus. PLoS Pathog 5: e1000578.
47. Bennett SR, Carbone FR, Karamalis F, Miller JF, Heath WR, (1997) Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J Exp Med 186: 65-70.
48. Janssen EM, Lemmens EE, Wolfe T, Christen U, von Herrath MG, et al. (2003) CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421: 852-856.
49. Salkowitz JR, Sieg SF, Harding CV, Lederman MM, (2004) In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4+ T cell help. J Infect Dis 189: 971-983.
50. Sester M, Sester U, Alarcon Salvador S, Heine G, Lipfert S, et al. (2002) Age-related decrease in adenovirus-specific T cell responses. J Infect Dis 185: 1379-1387.
51. Jackson SE, Mason GM, Wills MR, (2011) Human cytomegalovirus immunity and immune evasion. Virus Res 157: 151-160.
52. Wucherpfennig KW, Strominger JL, (1995) Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein. Cell 80: 695-705.
53. Hemmer B, Vergelli M, Gran B, Ling N, Conlon P, et al. (1998) Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. J Immunol 160: 3631-3636.
54. Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, et al. (2002) A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol 3: 940-943.
55. Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, et al. (2004) Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol 173: 1689-1698.
56. Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM, (2006) Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 107: 3925-32.
57. Nikiforow S, Bottomly K, Miller G, (2001) CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation. J Virol 75: 3740-52.
58. Sloan-Lancaster J, Allen PM, (1996) Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu Rev Immunol 14: 1-27.
59. MacDonald AJ, Duffy M, Brady MT, McKiernan S, Hall W, et al. (2002) CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons. J Infect Dis 185: 720-727.