C-reactive protein increases BBB permeability: Implications for obesity and neuroinfammation

Cellular Physiology and Biochemistry

Volumn 30, Issue 5, 2012, Pages 1109-1119

  Hsuchou, Hung ^a   Kastin, Abba J ^a   Mishra, Pramod K ^a   Pan, Weihong ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Adipokines; Blood brain barrier; CRP; Infammation; Leptin; Permeability; Tight junction

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; CYCLOOXYGENASE 2; FIBRINOGEN; LEPTIN; PROTEIN ZO1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL MEMBRANE PERMEABILITY; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; GLIOSIS; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TRANSPORT; TIGHT JUNCTION; TRANSCYTOSIS; UPREGULATION;

AGOUTI; MUS;

ANIMALS; BLOOD-BRAIN BARRIER; C-REACTIVE PROTEIN; CAPILLARY PERMEABILITY; CENTRAL NERVOUS SYSTEM; INFLAMMATION; LEPTIN; MICE; MICE, INBRED C57BL; OBESITY;

EID: 84866641311     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000343302     Document Type: Article

References (35)

1. Chen K, Li F, Li J, Cai H, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ: Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 2006;12:425-432.
2. Dube MG, Torto R, Kalra SP: Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice. Peptides 2008;29:593-598.
3. Pan W, Hsuchou H, He Y, Sakharkar A, Cain C, Yu C, Kastin AJ: Astrocyte Leptin Receptor (ObR) and Leptin Transport in Adult-Onset Obese Mice. Endocrinology 2008;149:2798-2806. (Pubitemid 351724513)
4. Hsuchou H, He Y, Kastin AJ, Tu H, Markadakis EN, Rogers RC, Fossier PB, Pan W: Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain 2009;132:889-902.
5. Hsuchou H, Kastin AJ, Pan W: Blood-Borne Metabolic Factors in Obesity Exacerbate Injury-Induced Gliosis. J Mol Neurosci 2012;47:267-277.
6. Li J, Li F, Zhao A: Inflammation and leptin. Drug Discov Today: Disease Mechanisms 2006;3:387-393. (Pubitemid 46296635)
7. Tillett WS, Francis T: Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med 1930;52:561-571.
8. Pepys MB: C-reactive protein fifty years on. Lancet 1981;1:653-657. (Pubitemid 11153628)
9. Marnell L, Mold C, Du Clos TW: C-reactive protein: ligands, receptors and role in inflammation. Clin Immunol 2005;117:104-111. (Pubitemid 41407719)
10. Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan RS, Larson MG, Meigs JB, Keaney JF Jr, Lipinska I, Kathiresan S, Benjamin EJ, De Carli C: Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. Neurology 2007;68:1032-1038. (Pubitemid 46569138)
11. Satizabal CL, Zhu YC, Mazoyer B, Dufouil C, Tzourio C: Circulating IL-6 and CRP are associated with MRI findings in the elderly: The 3C-Dijon Study. Neurology 2012;78:720-727.
12. Wersching H, Duning T, Lohmann H, Mohammadi S, Stehling C, Fobker M, Conty M, Minnerup J, Ringelstein EB, Berger K, Deppe M, Knecht S: Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology 2010;74:1022-1029.
13. Jefferson AL, Massaro JM, Beiser AS, Seshadri S, Larson MG, Wolf PA, Au R, Benjamin EJ: Inflammatory markers and neuropsychological functioning: the Framingham Heart Study. Neuroepidemiology 2011;37:21-30.
14. Van Dijk EJ, Prins ND, Vermeer SE, Vrooman HA, Hofman A, Koudstaal PJ, Breteler MM: C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study. Circulation 2005;112:900-905. (Pubitemid 41170078)
15. Mineo C, Shaul PW: Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae. Cardiovasc Res 2006;70:31-41.
16. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptides 1996;17:305-311. (Pubitemid 26124406)
17. Tu H, Pan W, Feucht L, Kastin AJ: Convergent trafficking pattern of leptin after endocytosis mediated by ObRa - ObRd. J Cell Physiol 2007;212:215-222. (Pubitemid 46867604)
18. Tu H, Hsuchou H, Kastin AJ, Wu X, Pan W: Unique leptin trafficking by a tailless receptor. FASEB J 2010;24:2281-2291.
19. Kastin AJ, Pan W, Akerstrom V, Hackler L, Wang CF, Kotz CM: Novel peptide-peptide cooperation may transform feeding behavior. Peptides 2002;23:2189-2196. (Pubitemid 36092053)
20. Pan W, Akerstrom V, Zhang J, Pejovic V, Kastin AJ: Modulation of feeding-related peptide/protein signals by the blood-brain barrier. J Neurochem 2004;90:455-461. (Pubitemid 38938230)
21. Pan W, Tu H, Hsuchou H, Daniel J, Kastin AJ: Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity. J Mol Neurosci 2007;33:232-238. (Pubitemid 350242532)
22. Zhang Y, Wu X, He Y, Kastin AJ, Hsuchou H, Rosenblum CI, Pan W: Melanocortin potentiates leptin-induced STAT3 signaling via MAPK pathway. J Neurochem 2009;110:390-399.
23. Pan W, Tu H, Kastin AJ: Differential BBB interactions of three ingestive peptides: Obestatin, ghrelin, and adiponectin. Peptides 2006;27:911-916.
24. Kastin AJ, Akerstrom V, Pan W: Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides 2001;22:2127-2136.
25. Pan W, Kastin AJ: Interactions of IGF-1 with the blood-brain barrier in vivo and in situ. Neuroendocrinology 2000;72:171-178.
26. Yu C, Kastin AJ, Ding Y, Pan W: Gamma glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke. Exp Neurol 2007;203:116-122. (Pubitemid 44821169)
27. Hsuchou H, Kastin AJ, Tu H, Abbott NJ, Couraud PO, Pan W: Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells. J Neurochem 2010;115:1288-1298.
28. Weksler B, Sublieau E, Perriere N, Charneau P, Holloway K, Leveque M, Tricoire-Leignel H, Nicotra A, Bourdoulous S, Turowski P, Male D, Roux F, Greenwood J, Romero I, Couraud P: Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J 2005;19:1872-1874. (Pubitemid 41598779)
29. Schrade A, Sade H, Couraud PO, Romero IA, Weksler BB, Niewoehner J: Expression and localization of claudins-3 and -12 in transformed human brain endothelium. Fluids Barriers CNS 2012;9:6.
30. Kuhlmann CR, Librizzi L, Closhen D, Pflanzner T, Lessmann V, Pietrzik CU, De Curtis M, Luhmann HJ: Mechanisms of C-reactive protein-induced blood-brain barrier disruption. Stroke 2009;40:1458-1466.
31. Mastronardi CA, Yu WH, Srivastava VK, Dees WL, McCann SM: Lipopolysaccharide-induced leptin release is neurally controlled. Proc Natl Acad Sci U S A 2001;98:14720-14725. (Pubitemid 33121458)
32. Mastronardi CA, Srivastava V, Yu WH, Les DW, McCann SM: Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by alpha-melanocyte-stimulating hormone. Neuroimmunomodulation 2005;12:182-188. (Pubitemid 40868679)
33. Banks WA, Clever CM, Farrell CL: Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice. Am J Physiol 2000;278:E1158-E1165. (Pubitemid 30439155)
34. Banks WA, Dohgu S, Lynch JL, Fleegal-De Motta MA, Erickson MA, Nakaoke R, Vo TQ: Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier. Endocrinology 2008;149:1514-1523. (Pubitemid 351468333)
35. Mukherjee R, Choi JW, Choi DK, Oh TS, Liu H, Yun JW: Gender-dependent protein expression in white adipose tissues of lean and obese rats fed a high fat diet. Cell Physiol Biochem 2012;29:617-634.