Delayed resolution of inflammatory response compared with clinical recovery in patients with acute exacerbations of chronic obstructive pulmonary disease

Respirology

Volumn 17, Issue 7, 2012, Pages 1080-1085

  Mohan, Anant ^a   Prasad, Dharmendra ^a   Sharma, Alpana ^a   Arora, Sneh ^a   Guleria, Randeep ^a   Sharma, Surendra K ^a   Pandey, Ravinder M ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

acute exacerbation; acute phase reactant; chronic obstructive pulmonary disease; cytokine; inflammation

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; C REACTIVE PROTEIN; CREATININE; FIBRINOGEN; INTERLEUKIN 6;

ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ARTIFICIAL VENTILATION; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; CHEST INFECTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ASSESSMENT; COMORBIDITY; CONVALESCENCE; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; DISEASE DURATION; DISEASE EXACERBATION; DYSPNEA; FEMALE; FEVER; HEART FAILURE; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; INFLAMMATION; LENGTH OF STAY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OXYGEN TENSION; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SCORING SYSTEM; SMOKING; TREATMENT PLANNING; UPPER RESPIRATORY TRACT INFECTION; WHEEZING;

ACUTE DISEASE; ACUTE-PHASE PROTEINS; AGED; BIOLOGICAL MARKERS; CYTOKINES; DISEASE PROGRESSION; FEMALE; HOSPITALIZATION; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84866639311     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2012.02216.x     Document Type: Article

References (28)

1. Wouters EF,. Economic analysis of the confronting COPD survey: an overview of results. Respir. Med. 2003; 97 (Suppl. C): S3-14.
2. Gompertz S, Bayley DL, Hill SL, et al,. Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. Thorax 2001; 56: 36-41.
3. Bhowmik A, Seemungal TA, Sapsford RJ, et al,. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax 2000; 55: 114-20.
4. Kharitonov SA, Barnes PJ,. Exhaled markers of pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 163: 1693-722.
5. Dev D, Wallace E, Sankaran R, et al,. Value of C-reactive protein measurements in exacerbations of chronic obstructive pulmonary disease. Respir. Med. 1998; 92: 664-7.
6. Roland M, Bhowmik A, Sapsford RJ, et al,. Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease. Thorax 2001; 56: 30-5.
7. Wedzicha JA, Seemungal TA, MacCallum PK, et al,. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb. Haemost. 2000; 84: 210-15.
8. Celli BR, MacNee W,. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur. Respir. J. 2004; 23: 932-46.
9. Rodriguez-Roisin R,. Toward a consensus definition for COPD exacerbations. Chest 2000; 117 (5 Suppl. 2): 398S-401S.
10. Anthonisen NR, Manfreda J, Warren CP, et al,. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann. Intern. Med. 1987; 106: 196-204.
11. Charlson ME, Pompei P, Ales KL, et al,. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 1987; 40: 373-83.
12. Charlson M, Szatrowski TP, Peterson J, et al,. Validation of a combined comorbidity index. J. Clin. Epidemiol. 1994; 47: 1245-51.
13. Hurst JR, Donaldson GC, Perera WR, et al,. Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2006; 174: 867-74.
14. Karadag F, Karul AB, Cildag O, et al,. Biomarkers of systemic inflammation in stable and exacerbation phases of COPD. Lung 2008; 186: 403-9.
15. Koutsokera A, Kiropoulos TS, Nikoulis DJ, et al,. Clinical, functional and biochemical changes during recovery from COPD exacerbations. Respir. Med. 2009; 103: 919-26.
16. Perera WR, Hurst JR, Wilkinson TM, et al,. Inflammatory changes, recovery and recurrence at COPD exacerbation. Eur. Respir. J. 2007; 29: 527-34.
17. Pinto-Plata VM, Livnat G, Girish M, et al,. Systemic cytokines, clinical and physiological changes in patients hospitalized for exacerbation of COPD. Chest 2007; 131: 37-43.
18. Mehrotra N, Freire AX, Bauer DC, et al,. Predictors of mortality in elderly subjects with obstructive airway disease: the PILE score. Ann. Epidemiol. 2010; 20: 223-32.
19. Eid AA, Ionescu AA, Nixon LS, et al,. Inflammatory response and body composition in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 164: 1414-18.
20. Di Francia M, Barbier D, Mege JL, et al,. Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1994; 150: 1453-5.
21. Takabatake N, Nakamura H, Abe S, et al,. The relationship between chronic hypoxemia and activation of the tumor necrosis factor-alpha system in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2000; 161: 1179-84.
22. Krommidas G, Kostikas K, Papatheodorou G, et al,. Plasma leptin and adiponectin in COPD exacerbations: associations with inflammatory biomarkers. Respir. Med. 2010; 104: 40-6.
23. Broekhuizen R, Wouters EF, Creutzberg EC, et al,. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 2006; 61: 17-22.
24. Cano NJ, Pichard C, Roth H, et al,. C-reactive protein and body mass index predict outcome in end-stage respiratory failure. Chest 2004; 126: 540-6.
25. Daniels JM, Schoorl M, Snijders D, et al,. Procalcitonin vs C-reactive protein as predictive markers of response to antibiotic therapy in acute exacerbations of COPD. Chest 2010; 138: 1108-15.
26. Sin DD, Man SF,. Systemic inflammation and mortality in chronic obstructive pulmonary disease. Can. J. Physiol. Pharmacol. 2007; 85: 141-7.
27. Stolz D, Christ-Crain M, Morgenthaler NG, et al,. Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD. Chest 2007; 131: 1058-67.
28. Groenewegen KH, Dentener MA, Wouters EF,. Longitudinal follow-up of systemic inflammation after acute exacerbations of COPD. Respir. Med. 2007; 101: 2409-15.