The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development

Genesis

Volumn 50, Issue 9, 2012, Pages 665-671

  Feuermann, Yonatan ^a   Robinson, Gertraud W ^a   Zhu, Bing Mei ^b   Kang, Keunsoo ^a   Raviv, Noa ^a   Yamaji, Daisuke ^a   Hennighausen, Lothar ^a,c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c Dankook University   (South Korea)

Author keywords

Mammary gland; MiR 17 92 cluster; STAT5

Indexed keywords

MICRORNA; MICRORNA 17; MICRORNA 92; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CELL; BREAST DEVELOPMENT; CELL FUNCTION; GENE CLUSTER; GENE EXPRESSION; LACTATION; MAMMARY GLAND; MOUSE; NONHUMAN; PREPUBERTY; PRIORITY JOURNAL; PROTEIN TARGETING; STEM CELL;

ANIMALS; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; EPITHELIAL CELLS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, NUDE; MICRORNAS; MULTIGENE FAMILY; PREGNANCY; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; STAT5 TRANSCRIPTION FACTOR; STEM CELLS;

EID: 84866628441     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.22023     Document Type: Article

References (27)

1. Avril-Sassen S, Goldstein LD, Stingl J, Blenkiron C, Le Quesne J, Spiteri I, Karagavriilidou K, Watson CJ, Tavare S, Miska EA, Caldas C. 2009. Characterisation of microRNA expression in post-natal mouse mammary gland development. BMC Genomics 10: 548.
2. Bartel DP. 2004. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
3. Bry C, Maass K, Miyoshi K, Willecke K, Ott T, Robinson GW, Hennighausen L. 2004. Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development. Dev Biol 267: 418-429.
4. Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA. 2007. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 178: 280-290.
5. Carrington JC, Ambros V. 2003. Role of microRNAs in plant and animal development. Science 301: 336-338.
6. Cloonan N, Brown MK, Steptoe AL, Wani S, Chan WL, Forrest AR, Kolle G, Gabrielli B, Grimmond SM. 2008. The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biol 9: R127.
7. Crowley MR, Bowtell D, Serra R. 2005. TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma. Dev Biol 279: 58-72.
8. Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Deng CX, Robinson GW, Hennighausen L. 2004. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 24: 8037-8047.
9. Dai X, Chen Y, Di L, Podd A, Li G, Bunting KD, Hennighausen L, Wen R, Wang D. 2007. Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol 179: 1068-1079.
10. Dews M, Fox JL, Hultine S, Sundaram P, Wang W, Liu YY, Furth E, Enders GH, El-Deiry W, Schelter JM, Cleary MA, Thomas-Tikhonenko A. 2010. The myc-miR-17-92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res 70: 8233-8246.
11. Forrester E, Chytil A, Bierie B, Aakre M, Gorska AE, Sharif-Afshar AR, Muller WJ, Moses HL. 2005. Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res 65: 2296-2302.
12. Gao Y, Schug J, McKenna LB, Le Lay J, Kaestner KH, Greenbaum LE. 2011. Tissue-specific regulation of mouse MicroRNA genes in endoderm-derived tissues. Nucleic Acids Research 39: 454-463.
13. Grillari J, Hackl M, Grillari-Voglauer R. 2010. miR-17-92 cluster: Ups and downs in cancer and aging. Biogerontology 11: 501-506.
14. Lee RC, Feinbaum RL, Ambros V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854.
15. Lu Y, Thomson JM, Wong HY, Hammond SM, Hogan BL. 2007. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol 310: 442-453.
16. Mestdagh P, Bostrom AK, Impens F, Fredlund E, Van Peer G, De Antonellis P, von Stedingk K, Ghesquiere B, Schulte S, Dews M, Thomas-Tikhonenko A, Schulte JH, Zollo M, Schramm A, Gevaert K, Axelson H, Speleman F, Vandesompele J. 2010. The miR-17-92 microRNA cluster regulates multiple components of the TGF-beta pathway in neuroblastoma. Mol Cell 40: 762-773.
17. Miyoshi K, Shillingford JM, Smith GH, Grimm SL, Wagner KU, Oka T, Rosen JM, Robinson GW, Hennighausen L. 2001. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol 155: 531-542.
18. Moses H, Barcellos-Hoff MH. 2010. TGF-beta biology in mammary development and breast cancer. Cold Spring Harb Perspect Biol 3: a003277.
19. Petrocca F, Vecchione A, Croce CM. 2008. Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res 68: 8191-8194.
20. Pierce DFJr, Johnson MD, Matsui Y, Robinson SD, Gold LI, Purchio AF, Daniel CW, Hogan BL, Moses HL. 1993. Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. Genes Dev 7: 2308-2317.
21. Trompeter HI, Abbad H, Iwaniuk KM, Hafner M, Renwick N, Tuschl T, Schira J, Muller HW, Wernet P. 2011. MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC. PLoS One 6: e16138.
22. Ucar A, Vafaizadeh V, Jarry H, Fiedler J, Klemmt PA, Thum T, Groner B, Chowdhury K. 2010. miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development. Nat Genet 42: 1101-1108.
23. Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T. 2008. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132: 875-886.
24. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM. 2006. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103: 2257-2261.
25. Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L, Li M, Furth PA, Hennighausen L. 1997. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 25: 4323-4330.
26. Yamaji D, Na R, Feuermann Y, Pechhold S, Chen W, Robinson GW, Hennighausen L. 2009. Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev 23: 2382-2387.
27. Zhu BM, Kang K, Yu JH, Chen W, Smith HE, Lee D, Sun HW, Wei L, Hennighausen L. 2012. Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes. Nucleic Acids Res.