Inhibition of intrinsic xase by protein s: A novel regulatory role of protein s independent of activated protein c

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 10, 2012, Pages 2387-2393

  Chattopadhyay, Rima ^a   Sengupta, Tanusree ^a   Majumder, Rinku ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

anticoagulants; blood coagulation; factor IXa; protein S; thrombosis

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 8A; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9A; PHOSPHATIDYLSERINE; PROTEIN S; THROMBIN; THROMBOPLASTIN;

ARTICLE; BLOOD CLOTTING; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; PARTIAL THROMBOPLASTIN TIME; PHOSPHOLIPID VESICLE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; THROMBOCYTE RICH PLASMA;

BLOOD COAGULATION; FACTOR IXA; FACTOR VIIIA; FEEDBACK, PHYSIOLOGICAL; HUMANS; PARTIAL THROMBOPLASTIN TIME; PROTEIN C; PROTEIN S; SIGNAL TRANSDUCTION; THROMBIN;

EID: 84866618147     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.250928     Document Type: Article

References (37)

1. Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science. 1964;145:1310-1312.
2. Macfarlane RG. An enzyme cascade in the blood clotting mechanism, and its function as a biological amplifer. Nature.1964;202:498-499.
3. Lollar P, Knutson GJ, Fass DN. Stabilization of thrombin-activated porcine factor VIII:C by factor IXa phospholipid. Blood. 1984;63:1303-1308.
4. Gilbert GE, Arena AA. Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine. J Biol Chem. 1996;271:11120-11125.
5. Bucciarelli P, Rosendaal FR, Tripodi A, Mannucci PM, De Stefano V, Palareti G, Finazzi G, Baudo F, Quintavalla R. Risk of venous thromboem-bolism and clinical manifestations in carriers of antithrombin, protein C, protein S defciency, or activated protein C resistance: a multicenter collaborative family study. Arterioscler Thromb Vasc Biol. 1999;19:1026-1033.
6. Simmonds RE, Ireland H, Lane DA, Zöller B, García de Frutos P, Dahlbäck B. Clarifcation of the risk for venous thrombosis associated with hereditary protein S defciency by investigation of a large kindred with a characterized gene defect. Ann Intern Med. 1998;128:8-14.
7. Horowitz IN, Galvis AG, Gomperts ED. Arterial thrombosis and protein S defciency. J Pediatr. 1992;121:934-937.
8. Arnljots B, Dahlbäck B. Protein S as an in vivo cofactor to activated protein C in prevention of microarterial thrombosis in rabbits. J Clin Invest. 1995;95:1987-1993.
9. D'Angelo A, Lockhart MS, D'Angelo SV, Taylor FB Jr. Protein S is a cofactor for activated protein C neutralization of an inhibitor of plas-minogen activation released from platelets. Blood. 1987;69:231-237.
10. Koedam JA, Meijers JC, Sixma JJ, Bouma BN. Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor. J Clin Invest. 1988;82:1236-1243.
11. Solymoss S, Tucker MM, Tracy PB. Kinetics of inactivation of membrane-bound factor Va by activated protein C. Protein S modulates factor Xa protection. J Biol Chem. 1988;263:14884-14890.
12. Heeb MJ, Mesters RM, Tans G, Rosing J, Griffn JH. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J Biol Chem. 1993;268:2872-2877.
13. Heeb MJ, Rosing J, Bakker HM, Fernandez JA, Tans G, Griffn JH. Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci USA. 1994;91:2728-2732.
14. Hackeng TM, van 't Veer C, Meijers JC, Bouma BN. Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa. J Biol Chem. 1994;269:21051-21058.
15. Butenas S, van't Veer C, Mann KG. "Normal" thrombin generation. Blood. 1999;94:2169-2178.
16. van 't Veer C, Butenas S, Golden NJ, Mann KG. Regulation of prothrom-binase activity by protein S. Thromb Haemost. 1999;82:80-87.
17. Seré KM, Willems GM, Rosing J, Hackeng TM. Protein S multimers are generated in vitro and affect protein S structure-function analyses. Semin Hematol. 2006;43:S111-S120.
18. Seré KM, Janssen MP, Willems GM, Tans G, Rosing J, Hackeng TM. Purifed protein S contains multimeric forms with increased APC-independent anticoagulant activity. Biochemistry. 2001;40:8852-8860.
19. Seré KM, Rosing J, Hackeng TM. Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance. Blood. 2004;104:3624-3630.
20. Koppelman SJ, Hackeng TM, Sixma JJ, Bouma BN. Inhibition of the intrinsic factor X activating complex by protein S: evidence for a specifc binding of protein S to factor VIII. Blood. 1995;86:1062-1071.
21. Takeyama M, Nogami K, Saenko EL, Soeda T, Nishiya K, Ogiwara K, Yoshioka A, Shima M. Protein S down-regulates factor Xase activity independent of activated protein C: specifc binding of factor VIII(a) to protein S inhibits interactions with factor IXa. Br J Haematol. 2008;143:409-420.
22. Hackeng TM, Seré KM, Tans G, Rosing J. Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Proc Natl Acad Sci USA. 2006;103:3106-3111.
23. Rosing J, Maurissen LF, Tchaikovski SN, Tans G, Hackeng TM. Protein S is a cofactor for tissue factor pathway inhibitor. Thromb Res. 2008;122 Suppl 1:S60-S63.
24. Rand MD, Lock JB, van't Veer C, Gaffney DP, Mann KG. Blood clotting in minimally altered whole blood. Blood. 1996;88:3432-3445.
25. Chen PS Jr, Toribara TY, Huber W. Microdetermination of phosphorus. Analytical chemistry. 1956;28:1756-1758.
26. Phillips DR, Agin PP. Platelet membrane defects in Glanzmann's throm-basthenia. Evidence for decreased amounts of two major glycoproteins. J Clin Invest. 1977;60:535-545.
27. Lentz BR, Carpenter TJ, Alford DR. Spontaneous fusion of phosphati-dylcholine small unilamellar vesicles in the fuid phase. Biochemistry. 1987;26:5389-5397.
28. Weinreb GE, Mukhopadhyay K, Majumder R, Lentz BR. Cooperative roles of factor V(a) and phosphatidylserine-containing membranes as cofactors in prothrombin activation. J Biol Chem. 2003;278:5679-5684.
29. Pratt CW, Monroe DM. Microplate coagulation assays. BioTechniques. 1992;13:430-433.
30. Hemker HC, Giesen P, Al Dieri R, Regnault V, de Smedt E, Wagenvoord R, Lecompte T, Béguin S. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb. 2003;33:4-15.
31. Bunce MW, Toso R, Camire RM. Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro. Blood. 2011;117:290-298.
32. Buyue Y, Sheehan JP. Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite. Blood. 2009;114:3092-3100.
33. Mathur A, Zhong D, Sabharwal AK, Smith KJ, Bajaj SP. Interaction of factor IXa with factor VIIIa. Effects of protease domain Ca2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X. J Biol Chem. 1997;272:23418-23426.
34. Broze GJ Jr. Tissue factor pathway inhibitor and the current concept of blood coagulation. Blood Coagul Fibrinolysis. 1995;6 Suppl 1:S7-13.
35. Castoldi E, Simioni P, Kalafatis M, Lunghi B, Tormene D, Girelli D, Girolami A, Bernardi F. Combinations of 4 mutations (FV R506Q, FV H1299R, FV Y1702C, PT 20210G/A) affecting the prothrombinase complex in a thrombophilic family. Blood. 2000;96:1443-1448.
36. Ndonwi M, Broze G Jr. Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition offactor VIIa-tissue factor. J Thromb Haemost. 2008;6:1044-1046.
37. Castoldi E, Hackeng TM. Regulation of coagulation by protein S. Curr Opin Hematol. 2008;15:529-536.