Ferritin is independently associated with the presence of coronary artery calcium in 12 033 men

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 10, 2012, Pages 2525-2530

  Sung, Ki Chul ^a   Kang, Seok Min ^b   Cho, Eun Joo ^c   Park, Jeong Bae ^d   Wild, Sarah H ^e   Byrne, Christopher D ^f  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Yonsei University Health System   (South Korea)

^c St Paul's Hospital   (South Korea)

^d Catholic Kwandong University   (South Korea)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

atherosclerosis; cardiometabolic risk factors; cardiovascular disease; ferritin; metabolic syndrome; transferrin coronary artery calcium score; type 2 diabetes mellitus

Indexed keywords

CALCIUM; FERRITIN; TRANSFERRIN;

ADULT; ARTICLE; CARDIOVASCULAR RISK; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTEYR CALCIUM SCORE; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE MARKER; FERRITIN BLOOD LEVEL; FRAMINGHAM RISK SCORE; HUMAN; HYPERTENSION; INFLAMMATION; IRON BINDING CAPACITY; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; SCORING SYSTEM;

ADULT; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CALCIUM; CARDIOVASCULAR DISEASES; COHORT STUDIES; COMORBIDITY; CORONARY VESSELS; DIABETES MELLITUS; FERRITINS; HUMANS; INCIDENCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; REPUBLIC OF KOREA; RISK FACTORS;

EID: 84866606743     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.253088     Document Type: Article

References (34)

1. Illouz F, Roulier V, Rod A, Gallois Y, Pellé CP, Aubé C, Rohmer V, Ritz P, Ducluzeau PH. Distribution of adipose tissue: quantifcation and relationship with hepatic steatosis and vascular profles of type 2 diabetic patients with metabolic syndrome. Diabetes Metab. 2008;34:68-74.
2. Guillum RF. Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men: the Third National Health and Nutrition Examination Survey. Int J Obes Relat Metab Disord. 2001;25:639-645.
3. Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care. 2004;27:2422-2428.
4. Oshaug A, Bugge KH, Bjønnes CH, Borch-Iohnsen B, Neslein IL. Associations between serum ferritin and cardiovascular risk factors in healthy young men. A cross sectional study. Eur J Clin Nutr. 1995;49:430-438.
5. Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Meth Enzymol. 1990;186:1-85.
6. Fernández-Real JM, Ricart W. Insulin resistance and chronic cardiovascular infammatory syndrome. Endocr Rev. 2003;24:278-301.
7. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA. 1999;282:2131-2135.
8. Salonen JT, Nyyssönen K, Korpela H, Tuomilehto J, Seppänen R, Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation. 1992;86:803-811.
9. Mainous AG 3rd, Wells B, Carek PJ, Gill JM, Geesey ME. The mortality risk of elevated serum transferrin saturation and consumption of dietary iron. Ann Fam Med. 2004;2:139-144.
10. Hramiak IM, Finegood DT, Adams PC. Factors affecting glucose tolerance in hereditary hemochromatosis. Clin Invest Med. 1997;20:110-118.
11. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB. The role of iron in type 2 diabetes in humans. Biochim Biophys Acta. 2009;1790:671-681.
12. Fernández-Real JM, López-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002;51:2348-2354.
13. Haap M, Machann J, von Friedeburg C, Schick F, Stefan N, Schwenzer NF, Fritsche A, Häring HU, Thamer C. Insulin sensitivity and liver fat: role of iron load. J Clin Endocrinol Metab. 2011;96:E958-E961.
14. Budoff MJ, Achenbach S, Blumenthal RS, Carr JJ, Goldin JG, Greenland P, Guerci AD, Lima JA, Rader DJ, Rubin GD, Shaw LJ, Wiegers SE; American Heart Association Committee on Cardiovascular Imaging and Intervention; American Heart Association Council on Cardiovascular Radiology and Intervention; American Heart Association Committee on Cardiac Imaging, Council on Clinical Cardiology. Assessment of coronary artery disease by cardiac computed tomography: a scientifc statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation. 2006;114:1761-1791.
15. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr; International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640-1645.
16. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantifcation of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-832.
17. Koorts AM, Viljoen M. Ferritin and ferritin isoforms II: protection against uncontrolled cellular proliferation, oxidative damage and infam-matory processes. Arch Physiol Biochem. 2007;113:55-64.
18. Menke A, Fernández-Real JM, Muntner P, Guallar E. The association of biomarkers of iron status with peripheral arterial disease in US adults. BMC Cardiovasc Disord. 2009;9:34.
19. Danesh J, Appleby P. Coronary heart disease and iron status: meta-analyses of prospective studies. Circulation. 1999;99:852-854.
20. Menke A, Muntner P, Fernandez-Real JM, Guallar E. The association of biomarkers of iron status with mortality in US adults. Nutr Metab Cardiovasc Dis. February 15, 2011. DOI: 10.1016/j.numecd.2010.11.011.: http://www. sciencedirect.com/science/article/pii/S0939475310002954. Accessed July 25, 2012.
21. Valenti L, Swinkels DW, Burdick L, Dongiovanni P, Tjalsma H, Motta BM, Bertelli C, Fatta E, Bignamini D, Rametta R, Fargion S, Fracanzani AL. Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 2011;21:568-575.
22. Lee KR, Sweeney G, Kim WY, Kim KK. Serum ferritin is linked with aortic stiffness in apparently healthy Korean women. Crit Pathw Cardiol. 2010;9:160-163.
23. Jerome L. Iron in arterial plaque: A modifable risk factor for atherosclerosis. Biochimica et Biophysica Acta (BBA)-General Subjects. 2009;1790:718-723.
24. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA. 2001;98:8780-8785.
25. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loréal O. A new mouse liver-specifc gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-7819.
26. Chen YH, Chau LY, Chen JW, Lin SJ. Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients. Diabetes Care. 2008;31:1615-1620.
27. Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW, Charng MJ, Wu TC, Chen LC, Ding YA, Pan WH, Jou YS, Chau LY. Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet. 2002;111:1-8.
28. Minqin R, Rajendran R, Pan N, Tan BK, Ong WY, Watt F, Halliwell B. The iron chelator desferrioxamine inhibits atherosclerotic lesion development and decreases lesion iron concentrations in the cholesterol-fed rabbit. Free Radic Biol Med. 2005;38:1206-1211.
29. Lee HT, Chiu LL, Lee TS, Tsai HL, Chau LY. Dietary iron restriction increases plaque stability in apolipoprotein-e-defcient mice. J Biomed Sci. 2003;10:510-517.
30. Ponraj D, Makjanic J, Thong PS, Tan BK, Watt F. The onset of atherosclerotic lesion formation in hypercholesterolemic rabbits is delayed by iron depletion. FEBS Lett. 1999;459:218-222.
31. Lee TS, Shiao MS, Pan CC, Chau LY. Iron-defcient diet reduces atherosclerotic lesions in apoE-defcient mice. Circulation. 1999;99:1222-1229.
32. Achenbach S, Nomayo A, Couturier G, Ropers D, Pohle K, Schlundt C, Schmermund A, Matarazzo TJ, Hoffmann U, Daniel WG, Killip T. Relation between coronary calcium and 10-year risk scores in primary prevention patients. Am J Cardiol. 2003;92:1471-1475.
33. Desai MY, Nasir K, Braunstein JB, Rumberger JA, Post WS, Budoff MJ, Blumenthal RS. Underlying risk factors incrementally add to the standard risk estimate in detecting subclinical atherosclerosis in low-and intermediate-risk middle-aged asymptomatic individuals. Am Heart J. 2004;148:871-877.
34. Nordestgaard BG, Zacho J. Lipids, atherosclerosis and CVD risk: is CRP an innocent bystander? Nutr Metab Cardiovasc Dis. 2009;19:521-524.