Dietary iron restriction increases plaque stability in apolipoprotein-E-deficient mice

Journal of Biomedical Science

Volumn 10, Issue 5, 2003, Pages 510-517

  Lee, Hsueh Te ^a   Chiu, Li Li ^a   Lee, Tzong Shyuan ^a   Tsai, Hui Ling ^a   Chau, Lee Young ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Apolipoprotein E deficient mice; Atherosclerosis; Collagen; Iron; Matrix metalloproteinases; Plaque stability

Indexed keywords

APOLIPOPROTEIN E; FERRIC AMMONIUM CITRATE; GELATINASE B; INTERSTITIAL COLLAGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; ENZYME DEGRADATION; FEMALE; IMMUNOHISTOCHEMISTRY; IRON RESTRICTION; IRON STORAGE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; SPECIES COMPARISON;

ANIMALS; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CELL LINE; COLLAGEN; DIET; IMMUNOHISTOCHEMISTRY; IRON; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT;

ANIMALIA; MURINAE;

EID: 0041421288     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000072378     Document Type: Article

References (27)

1. Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinkerhoff CE, Sukhova GK, Libby P. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: A potential mechanism of lesion stabilization. Circulation 97:2433-2444;1998.
2. Araujo JA, Romano EL, Brito BE, Parthé V, Romano M, Bracho M, Montano RF, Cardier J. Iron overload augments the development of atherosclerotic lesions in rabbits. Arterioscler Thromb Vasc Biol 15:1172-1180;1995.
3. Brenneisen P, Wenk J, Klotz LO, Wlaschek M, Briviba K, Krieg T, Sies H, Scharffetter-Kochanek K. Central role of ferrous/ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts. J Biol Chem 273:5279-5287;1998.
4. Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM. Identification of 92-KD gelatinase in human coronary atherosclerotic lesions: Association of active enzyme synthesis with unstable angina. Circulation 91:2125-2131;1995.
5. Davies MJ. Reactive oxygen species, metalloproteinases and plaque stability. Circulation 97:2382-2383;1998.
6. Galis ZS, Asanuma K, Godin D, Meng X. N-Acetylcysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: New target for antioxidant therapy? Circulation 97:2445-2453;1998.
7. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94:2493-2503;1994.
8. Gardi C, Arezzini B, Fortino V, Comporti M. Effect of free iron on collagen synthesis, cell proliferation, and MMP-2 expression in rat hepatic stellate cells. Biochem Pharmacol 64:1139-1145;2002.
9. George SJ. Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis. Expert Opin Investig Drugs 9:993-1007;2000.
10. Kai H, Ikeda H, Yasukawa H, Kai M, Seki Y, Kuwahara F, Ueno T, Sugi K, Imaizumi T. Peripheral blood levels of matrix metalloproteinases-2 and -9 are elevated in patients with acute coronary syndromes. J Am Coll Cardiol 32:368-372;1998.
11. Kleiner DE, Stetler-Stevenson WG. Quantitative zymography: Detection of picogram quantities of gelatinases. Anal Biochem 218:325-329;1994.
12. Lee T-S, Chau L-Y. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 8:240-246;2002.
13. Lee T-S, Lee F-Y, Pang J-HS, Chau L-Y. Erythrophagocytosis and iron deposition in atherosclerotic lesions. Chin J Physiol 42:17-24;1999.
14. Lee F-Y, Lee T-S, Pan C-C, Huang A-L, Chau L-Y. Colocalization of iron and ceroid in human atherosclerotic lesions. Atherosclerosis 138:281-288;1998.
15. Lee T-S, Shiao M-S, Pan C-C, Chau L-Y. Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice. Circulation 99:1222-1229;1999.
16. Li Z, Li L, Zielke HR, Cheng L, Xiao R, Crow MT, Stetler-Stevenson WG, Froehlich J, Lakatta EG. Increased expression of 72 kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions. Am J Pathol 148:121-128;1996.
17. Libby P. Molecular bases of the acute coronary syndromes. Circulation 91:2844-2850;1995.
18. Libby P, Aikawa M. Stabilization of atherosclerotic plaques: New mechanisms and clinical targets. Nat Med 8:1257-1262;2002.
19. Nikkari ST, O'Brien KD, Ferguson M, Hatsukami T, Welgus HG, Alpers CE, Clowes AW. Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis. Circulation 92:1393-1398;1995.
20. Noji Y, Kajinami K, Kawashiri MA, Todo Y, Horita T, Nohara A, Higushikata T, Inazu A, Koizumi J, Takewgoshi T, Mabuchi H. Circulating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis. Clin Chem Lab Med 39:380-384;2001.
21. Pang J-HS, Jiang M-J, Chen Y-L, Wang F-W, Wang D-L, Chu S-H, Chau L-Y. Increased ferritin gene expression in atherosclerotic lesions. J Clin Invest 97:2204-2212;1996.
22. Porreca E, Ucchino S, Di Febbo C, Di Bartolomeo N, Angelucci D, Napolitano AM, Mezzetti A, Cuccurullo F. Antiproliferative effect of desferrioxamine on vascular smooth muscle cells in vitro and in vivo. Arterioscler Thromb 14:299-304;1994.
23. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis IS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro: Implication for atherosclerotic plaque stability. J Clin Invest 98:2572-2579;1996.
24. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apoE-evaluation of lesional development and progression. Arterioscler Thromb 14:141-147;1994.
25. Rice-Evans C, Burdon R. Free radical-lipid interactions and their pathological consequences. Prog Lipid Res 32:71-110;1993.
26. Shah PK, Falk E, Badimon JJ, Levy G, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques: Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation 92:1565-1569;1995.
27. Xu X-P, Meisel SR, Ong JM, Kaul S, Lercek B, Rajavashisth TB, Sharifi B, Shan PK. Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages. Circulation 99:993-998;1999.