Thrombin-sensitive dual fluorescence imaging and therapeutic agent for detection and treatment of synovial inflammation in murine rheumatoid arthritis

Journal of Controlled Release

Volumn 163, Issue 2, 2012, Pages 178-186

  Gabriel, Doris ^a,c   Lange, Norbert ^a   Chobaz Peclat, Veronique ^b   Zuluaga, Maria Fernanda ^a   Gurny, Robert ^a   Van Den Bergh, Hubert ^c   Busso, Nathalie ^b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c EPFL   (Switzerland)

Author keywords

Mice; Photodynamic therapy; Protease sensitive prodrugs; Rheumatoid arthritis; Thrombin

Indexed keywords

ARTHRITIC JOINTS; COLLAGEN-INDUCED ARTHRITIS; DOSE-DEPENDENT; DUAL FLUORESCENCE; ENHANCED PERMEABILITY AND RETENTION EFFECTS; EXPERIMENTAL MODELS; FLUORESCENCE EMISSION; LOCAL HEMORRHAGE; MICE; MUTUAL DISTANCES; PEPTIDE LINKERS; PHOTO-TOXICITY; PHOTOACTIVITY; POLYMERIC BACKBONE; PRODRUGS; PROTEOLYTIC CLEAVAGE; RHEUMATOID ARTHRITIS; SERINE PROTEASE; SITE SELECTIVE; SYNOVIAL INFLAMMATION; THERAPEUTIC AGENTS; THROMBIN; VASCULAR DAMAGE; WHOLE ANIMAL IMAGING;

AMINO ACIDS; CELL DEATH; DISEASES; FLUORESCENCE; HISTOLOGY; IRRADIATION; PATHOLOGY; PEPTIDES; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; POLYMERS; TISSUE;

ENZYMES;

COLLAGEN; PHOTOSENSITIZING AGENT; THROMBIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTHRITIS; ARTICLE; BLEEDING; FLUORESCENCE ANALYSIS; FLUORESCENCE IMAGING; IMMUNOHISTOCHEMISTRY; IRRADIATION; MALE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RHEUMATOID ARTHRITIS; STAINING; SYNOVITIS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; MALE; MICE; MICE, INBRED DBA; OPTICAL IMAGING; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PRODRUGS; THROMBIN;

EID: 84866563040     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.08.022     Document Type: Article

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