A tumor mRNA-triggered photodynamic molecular beacon based on oligonucleotide hairpin control of singlet oxygen production

Photochemical and Photobiological Sciences

Volumn 7, Issue 7, 2008, Pages 775-781

  Chen, Juan ^a,d   Lovell, Jonathan F ^b   Lo, Pui Chi ^c   Stefflova, Klara ^d   Niedre, Mark ^c   Wilson, Brian C ^a,c   Zheng, Gang ^a,b,c,d  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CAROTENOID; CGP 69846A; MESSENGER RNA; OLIGONUCLEOTIDE; PHORBOL DERIVATIVE; PHOTOSENSITIZING AGENT; PYROPHEOPHORBIDE; RNA; SINGLET OXYGEN;

ARTICLE; CANCER CELL; CHEMICAL INTERACTION; CONFORMATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG UPTAKE; FLUORESCENCE; HUMAN; HUMAN CELL; IRRADIATION; MOLECULAR BEACON; NUCLEOTIDE SEQUENCE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL;

EID: 46449091978     PISSN: 1474905X     EISSN: 14749092     Source Type: Journal    
DOI: 10.1039/b800653a     Document Type: Article

References (37)

1. T. J. Dougherty C. J. Gomer B. W. Henderson G. Jori D. Kessel M. Korbelik J. Moan Q. Peng Photodynamic therapy J. Natl. Cancer Inst. 1998 90 889 905
2. J. Chen K. Stefflova M. J. Niedre B. C. Wilson B. Chance J. D. Glickson G. Zheng Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation J. Am. Chem. Soc. 2004 126 11450 11451
3. G. Zheng J. Chen K. Stefflova M. Jarvi H. Li B. C. Wilson Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation Proc. Natl. Acad. Sci. USA 2007 104 8989 8994
4. J. Chen M. Jarvi P. C. Lo K. Stefflova B. C. Wilson G. Zheng Using the singlet oxygen scavenging property of carotenoid in photodynamic molecular beacons to minimize photodamage to non-targeted cells Photochem. Photobiol. Sci. 2007 6 1311 1317
5. K. Stefflova J. Chen G. Zheng Killer beacons for combined cancer imaging and therapy Curr. Med. Chem. 2007 14 2110 2125
6. J. B. Opalinska A. M. Gewirtz Nucleic-acid therapeutics: basic principles and recent applications Nat. Rev. Drug Discovery 2002 1 503 514
7. G. R. Devi siRNA-based approaches in cancer therapy Cancer Gene Ther. 2006 13 819 829
8. E. Iorns C. J. Lord N. Turner A. Ashworth Utilizing RNA interference to enhance cancer drug discovery Nat. Rev. Drug Discovery 2007 6 556 568
9. E. Clo J. W. Snyder N. V. Voigt P. R. Ogilby K. V. Gothelf DNA-programmed control of photosensitized singlet oxygen production J. Am. Chem. Soc. 2006 128 4200 4201
10. S. Tyagi F. R. Kramer Molecular beacons: probes that fluoresce upon hybridization Nat. Biotechnol. 1996 14 303 308
11. B. P. Monia J. F. Johnston T. Geiger M. Muller D. Fabbro Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase Nat. Med. 1996 2 668 675
12. A. Tsourkas M. A. Behlke G. Bao Hybridization of 2′-O-methyl and 2′-deoxy molecular beacons to RNA and DNA targets Nucleic Acids Res. 2003 31 5168 5174
13. J. Perlette W. Tan Real-time monitoring of intracellular mRNA hybridization inside single living cells Anal. Chem. 2001 73 5544 5550
14. D. L. Sokol X. Zhang P. Lu A. M. Gewirtz Real time detection of DNA.RNA hybridization in living cells Proc. Natl. Acad. Sci. USA 1998 95 11538 11543
15. W. Tan X. Fang J. Li X. Liu Molecular beacons: a novel DNA probe for nucleic acid and protein studies Chemistry 2000 6 1107 1111
16. A. Tsourkas M. A. Behlke S. D. Rose G. Bao Hybridization kinetics and thermodynamics of molecular beacons Nucleic Acids Res. 2003 31 1319 1330
17. X. H. Peng Z. H. Cao J. T. Xia G. W. Carlson M. M. Lewis W. C. Wood L. Yang Real-time detection of gene expression in cancer cells using molecular beacon imaging: new strategies for cancer research Cancer Res. 2005 65 1909 1917
18. D. P. Bratu B. J. Cha M. M. Mhlanga F. R. Kramer S. Tyagi Visualizing the distribution and transport of mRNAs in living cells Proc. Natl. Acad. Sci. USA 2003 100 13308 13313
19. A. K. Chen M. A. Behlke A. Tsourkas Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells Nucleic Acids Res. 2007 35 e105
20. Z. Q. Cui Z. P. Zhang X. E. Zhang J. K. Wen Y. F. Zhou W. H. Xie Visualizing the dynamic behavior of poliovirus plus-strand RNA in living host cells Nucleic Acids Res. 2005 33 3245 3252
21. M. Kloc K. Wilk D. Vargas Y. Shirato S. Bilinski L. D. Etkin Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex of Xenopus oocytes Development 2005 132 3445 3457
22. T. Matsuo In situ visualization of messenger RNA for basic fibroblast growth factor in living cells Biochim. Biophys. Acta 1998 1379 178 184
23. N. Nitin P. J. Santangelo G. Kim S. Nie G. Bao Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells Nucleic Acids Res. 2004 32 e58
24. A. J. Rodriguez J. Condeelis R. H. Singer J. B. Dictenberg Imaging mRNA movement from transcription sites to translation sites Semin. Cell Dev. Biol. 2007 18 202 208
25. A. Wang A. M. Salazar M. V. Yates A. Mulchandani W. Chen Visualization and detection of infectious coxsackievirus replication using a combined cell culture-molecular beacon assay Appl. Environ. Microbiol. 2005 71 8397 8401
26. T. J. Drake C. D. Medley A. Sen R. J. Rogers W. Tan Stochasticity of manganese superoxide dismutase mRNA expression in breast carcinoma cells by molecular beacon imaging ChemBioChem 2005 6 2041 2047
27. X. Tian M. R. Aruva W. Qin W. Zhu K. T. Duffy E. R. Sauter M. L. Thakur E. Wickstrom External imaging of CCND1 cancer gene activity in experimental human breast cancer xenografts with 99mTc-peptide-peptide nucleic acid-peptide chimeras J. Nucl. Med. 2004 45 2070 2082
28. M. R. Capecchi High efficiency transformation by direct microinjection of DNA into cultured mammalian cells Cell 1980 22 479 488
29. E. Neumann M. Schaefer-Ridder Y. Wang P. H. Hofschneider Gene transfer into mouse lyoma cells by electroporation in high electric fields EMBO J. 1982 1 841 845
30. P. L. Felgner T. R. Gadek M. Holm R. Roman H. W. Chan M. Wenz J. P. Northrop G. M. Ringold M. Danielsen Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure Proc. Natl. Acad. Sci. USA 1987 84 7413 7417
31. L. Benimetskaya G. B. Takle M. Vilenchik I. Lebedeva P. Miller C. A. Stein Cationic porphyrins: novel delivery vehicles for antisense oligodeoxynucleotides Nucleic Acids Res. 1998 26 5310 5317
32. G. Cesarone O. P. Edupuganti C. P. Chen E. Wickstrom Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1 Bioconjugate Chem. 2007 18 1831 1840
33. M. C. Morris P. Vidal L. Chaloin F. Heitz G. Divita A new peptide vector for efficient delivery of oligonucleotides into mammalian cells Nucleic Acids Res. 1997 25 2730 2736
34. S. Veldhoen S. D. Laufer A. Trampe T. Restle Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect Nucleic Acids Res. 2006 34 6561 6573
35. G. M. Barton R. Medzhitov Retroviral delivery of small interfering RNA into primary cells Proc. Natl. Acad. Sci. USA 2002 99 14943 14945
36. R. S. Tomar H. Matta P. M. Chaudhary Use of adeno-associated viral vector for delivery of small interfering RNA Oncogene 2003 22 5712 5715
37. M. J. Niedre A. J. Secord M. S. Patterson B. C. Wilson In vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapy Cancer Res. 2003 63 7986 7994