Thrombin-sensitive photodynamic agents: A novel strategy for selective synovectomy in rheumatoid arthritis

Journal of Controlled Release

Volumn 138, Issue 3, 2009, Pages 225-234

  Gabriel, Doris ^a   Busso, Nathalie ^b   So, Alexander ^b   van den Bergh, Hubert ^c   Gurny, Robert ^a   Lange, Norbert ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c EPFL   (Switzerland)

Author keywords

Photodynamic therapy; Protease sensitive prodrugs; Rheumatoid arthritis; Synovectomy; Thrombin

Indexed keywords

CANCEROUS LESIONS; COLLAGEN-INDUCED ARTHRITIS; ENZYMATIC DIGESTIONS; FLUORESCENCE EMISSION; IN-VITRO; IN-VIVO; LIGHT IRRADIATIONS; MACROMOLECULAR DRUGS; MINIMALLY INVASIVE; MOUSE MODELS; NOVEL STRATEGIES; PASSIVE TARGETING; PEPTIDE LINKERS; PHOTOACTIVITY; POLYMERIC BACKBONE; PRODRUGS; PROTEASE-SENSITIVE PRODRUGS; PROTEOLYTIC ACTIVITIES; RHEUMATOID ARTHRITIS; SELECTIVE FLUORESCENCE; SITE SELECTIVE; SYNOVECTOMY; SYNOVIOCYTES; THROMBIN;

AMINES; CELL DEATH; CELL MEMBRANES; DRUG DELIVERY; ENERGY TRANSFER; FLUORESCENCE; HEALTH; IRRADIATION; MACROMOLECULES; OPTICAL MATERIALS; PHOTOSENSITIZERS; PLASMONS; POLYMERS;

PHOTODYNAMIC THERAPY;

PHEOPHORBIDE A; PHOTOSENSITIZING AGENT; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; ENERGY TRANSFER; HUMAN; HUMAN CELL; MALE; MINIMALLY INVASIVE PROCEDURE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RHEUMATOID ARTHRITIS; SYNOVECTOMY; SYNOVIOCYTE; TISSUE DISTRIBUTION;

ANIMALS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; FIBROBLASTS; HUMANS; MALE; MICE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PRODRUGS; SYNOVIAL FLUID; THROMBIN;

EID: 68549112744     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.05.012     Document Type: Article

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