Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15461-15466

  Sun, Fei ^a   Ding, Yue ^b   Ji, Quanjiang ^a   Liang, Zhongjie ^b   Deng, Xin ^a   Wong, Catherine C L ^c   Yi, Chengqi ^a   Zhang, Liang ^a   Xie, Sherrie ^a   Alvarez, Sophie ^d   Hicks, Leslie M ^d   Luo, Cheng ^b   Jiang, Hualiang ^b   Lan, Lefu ^b   He, Chuan ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

Author keywords

Ser Thr kinase PknB; Transcriptional regulation

Indexed keywords

BACTERIAL PROTEIN; CEFTRIAXONE; MARR FAMILY GLOBAL TRANSCRIPTIONAL REGULATOR A PROTEIN; STAPHYLOCOCCAL ACCESSARY REGULATOR A PROTEIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL VIRULENCE; CONTROLLED STUDY; DRUG TARGETING; ENZYME PHOSPHORYLATION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; TRANSCRIPTION REGULATION;

ABSCESS; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; CYSTEINE; DRUG RESISTANCE, MICROBIAL; GENE EXPRESSION REGULATION, BACTERIAL; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; VANCOMYCIN; VIRULENCE; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); EUKARYOTA; STAPHYLOCOCCUS AUREUS;

EID: 84866550022     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205952109     Document Type: Article

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