Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15241-15246

  Bilokapic, Silvija ^a   Schwartz, Thomas U ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Macromolecular assemblies; Structural biology

Indexed keywords

ELY5 PROTEIN; NUP120 PROTEIN; NUP37 PROTEIN; SCHIZOSACCHAROMYCES POMBE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR BIOLOGY; NONHUMAN; NUCLEAR PORE COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SCHIZOSACCHAROMYCES POMBE;

DIMERIZATION; DNA-BINDING PROTEINS; HUMANS; MACROMOLECULAR SUBSTANCES; MOLECULAR CONFORMATION; MUTATION; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TRANSCRIPTION FACTORS;

SCHIZOSACCHAROMYCES POMBE;

EID: 84866545756     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205151109     Document Type: Article

References (35)

1. Güttinger S, Laurell E, Kutay U (2009) Orchestrating nuclear envelope disassembly and reassembly during mitosis. Nat Rev Mol Cell Biol 10(3):178-191.
2. Onischenko E, Weis K (2011) Nuclear pore complex-a coat specifically tailored for the nuclear envelope. Curr Opin Cell Biol 23:293-301.
3. Hetzer MW, Wente SR (2009) Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. Dev Cell 17:606-616.
4. Brohawn SG, Partridge JR, Whittle JRR, Schwartz TU (2009) The nuclear pore complex has entered the atomic age. Structure 17:1156-1168.
5. Cook AG, Conti E (2010) Nuclear export complexes in the frame. Curr Opin Struct Biol 20:247-252.
6. Rodríguez-Navarro S, Hurt E (2011) Linking gene regulation to mRNA production and export. Curr Opin Cell Biol 23:302-309.
7. Xu D, Farmer A, Chook YM (2010) Recognition of nuclear targeting signals by Karyopherin-β proteins. Curr Opin Struct Biol 20:782-790.
8. Strambio-De-Castillia C, Niepel M, Rout MP (2010) The nuclear pore complex: Bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol 11:490-501.
9. Frenkiel-Krispin D, Maco B, Aebi U, Medalia O (2010) Structural analysis of a metazoan nuclear pore complex reveals a fused concentric ring architecture. J Mol Biol 395:578-586.
10. Amlacher S, et al. (2011) Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile. Cell 146:277-289.
11. Theerthagiri G, Eisenhardt N, Schwarz H, Antonin W (2010) The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex. J Cell Biol 189:1129-1142.
12. Walther TC, et al. (2003) The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell 113:195-206. (Pubitemid 36514971)
13. Harel A, et al. (2003) Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores. Mol Cell 11:853-864. (Pubitemid 36566309)
14. Lutzmann M, Kunze R, Buerer A, Aebi U, Hurt E (2002) Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins. EMBO J 21:387-397. (Pubitemid 34137300)
15. Kampmann M, Blobel G (2009) Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex. Nat Struct Mol Biol 16:782-788.
16. Loïodice I, et al. (2004) The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Mol Biol Cell 15:3333-3344. (Pubitemid 38850127)
17. Rasala BA, Orjalo AV, Shen Z, Briggs S, Forbes DJ (2006) ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. Proc Natl Acad Sci USA 103:17801-17806. (Pubitemid 44852240)
18. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ (2002) Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol 158:915-927. (Pubitemid 35001082)
19. Rabut G, Doye V, Ellenberg J (2004) Mapping the dynamic organization of the nuclear pore complex inside single living cells. Nat Cell Biol 6:1114-1121. (Pubitemid 39468013)
20. Franz C, et al. (2007) MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO Rep 8(2):165-172. (Pubitemid 46420845)
21. Leksa NC, Brohawn SG, Schwartz TU (2009) The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture. Structure 17:1082-1091.
22. Seo H-S, et al. (2009) Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc Natl Acad Sci USA 106:14281-14286.
23. Chaudhuri I, Söding J, Lupas AN (2008) Evolution of the β-propeller fold. Proteins 71:795-803.
24. Kappel C, Zachariae U, Dölker N, Grubmüller H (2010) An unusual hydrophobic core confers extreme flexibility to HEAT repeat proteins. Biophys J 99:1596-1603.
25. Devos D, et al. (2006) Simple fold composition and modular architecture of the nuclear pore complex. Proc Natl Acad Sci USA 103:2172-2177. (Pubitemid 43271642)
26. Whittle JR, Schwartz TU (2009) Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. J Biol Chem 284:28442-28452.
27. Brohawn SG, Leksa NC, Spear ED, Rajashankar KR, Schwartz TU (2008) Structural evidence for common ancestry of the nuclear pore complex and vesicle coats. Science 322:1369-1373. (Pubitemid 352775247)
28. Eswar N, Eramian D, Webb B, Shen MY, Sali A (2008) Protein structure modeling with MODELLER. Methods Mol Biol 426:145-159.
29. Jeudy S, Schwartz TU (2007) Crystal structure of nucleoporin Nic96 reveals a novel, intricate helical domain architecture. J Biol Chem 282:34904-34912. (Pubitemid 350232422)
30. Neumann N, Lundin D, Poole AM (2010) Comparative genomic evidence for a complete nuclear pore complex in the last eukaryotic common ancestor. PLoS ONE 5:e13241.
31. Fernandez-Martinez J, et al. (2012) Structure-function mapping of a heptameric module in the nuclear pore complex. J Cell Biol 196:419-434.
32. Kampmann M, Atkinson CE, Mattheyses AL, Simon SM (2011) Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy. Nat Struct Mol Biol 18:643-649.
33. Brohawn SG, Schwartz TU (2009) Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nat Struct Mol Biol 16:1173-1177.
34. Liu HL, De Souza CPC, Osmani AH, Osmani SA (2009) The three fungal transmembrane nuclear pore complex proteins of Aspergillus nidulans are dispensable in the presence of an intact An-Nup84-120 complex. Mol Biol Cell 20:616-630.
35. Mitchell JM, Mansfeld J, Capitanio J, Kutay U, Wozniak RW (2010) Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane. J Cell Biol 191:505-521.