Fenofibrate attenuates nicotine-induced vascular endothelial dysfunction in the rat

Vascular Pharmacology

Volumn 55, Issue 5-6, 2011, Pages 163-168

  Chakkarwar, Vishal Arvind ^a  

^a ISF Institute of Pharmaceutical Sciences and Drug Research   (India)

Author keywords

Fenofibrate; Nicotine; Nitric oxide; Oxidative stress; Vascular endothelial dysfunction

Indexed keywords

ACETYLCHOLINE; CHOLESTEROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FENOFIBRATE; HIGH DENSITY LIPOPROTEIN; LIPID; MESSENGER RNA; NICOTINE; NITRATE; NITRITE; NITROPRUSSIDE SODIUM; PROTEIN P22; PROTEIN P22PHOX; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA; ARTICLE; ATTENUATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; ENDOTHELIAL DYSFUNCTION; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; SERUM; THORACIC AORTA; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR DISEASE; VASCULAR ENDOTHELIAL DYSFUNCTION; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA, THORACIC; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FENOFIBRATE; FREE RADICALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; MALE; NADPH OXIDASE; NICOTINE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; RATS; RATS, WISTAR; RNA, MESSENGER; SURFACE PROPERTIES; VASCULAR DISEASES; VASODILATION;

EID: 84866543653     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2011.08.215     Document Type: Article

References (31)

1. Allain C.C., Poon L.S., Chan C.S., et al. Enzymatic determination of total serum cholesterol. Clin. Chem. 1974, 20:470.
2. Ashakumary L., Vijayammal P.L. Effect of nicotine on antioxidant defence mechanisms in rats fed a high-fat diet. Pharmacology 1996, 52:153-158.
3. Balakumar P., Chakkarwar V.A., Kumar V., Jain A., Reddy J., Singh M. Experimental models for nephropathy. J. Renin. Angiotensin. Aldosterone Syst. 2008, 9:189-195.
4. Balakumar P., Sharma R., Singh M. Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in rats. Pharmacol. Res. 2008, 58:356-363.
5. Balakumar P., Chakkarwar V.A., Singh M. Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat. Mol. Cell. Biochem. 2009, 320:149-162.
6. Balakumar P., Chakkarwar V.A., Krishan P., Singh M. Vascular endothelial dysfunction: a tug of war in diabetic nephropathy?. Biomed. Pharmacother. 2009, 63:171-179.
7. Campbell S.C., Moffatt R.J., Stamford B.A. Smoking and smoking cessation-the relationship between cardiovascular disease and lipoprotein metabolism: a review. Atherosclerosis 2008, 201:225-235.
8. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987, 162:156-159.
9. Cosentino F., Rubatta S., Savoia C., Ventruelli V., Pagannone E., Volpe M.L. Endothelial dysfunction and stroke. J. Cardiovasc. Pharmacol. 2001, 38:S75-S78.
10. De Vriese A.S., Verbeuren T.J., de Voorde J.V., Lameire N.H., Vanhoutte P.M. Endothelial dysfunction in diabetes. Br. J. Pharmacol. 2000, 130:963-974.
11. Fang Q., Sun H., Arrick D.M., Mayhan W.G. Inhibition of NADPH oxidase improves impaired reactivity of pial arterioles during chronic exposure to nicotine. J. Appl. Physiol. 2006, 100:631-636.
12. Gullu H., Caliskan M., Ciftci O., Erdogan D., Topcu S., Yildirim E., et al. Light cigarette smoking impairs coronarymicrovascular functions as severely as smoking regular cigarettes. Heart 2007, 93:1274-1277.
13. Jiang D.J., Jia S.J., Zhou Z., Yuan Q., Li Y.J. Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction. Biochem. Biophys. Res. Commun. 2006, 349:683-693.
14. Kawashima S., Yokoyama M. Dysfunction of endothelial nitric oxide synthase and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2004, 224:998-1005.
15. Kobayashi N., Mita S., Yoshida K. Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 via NF-jB induced by oxidative stress. Hypertension 2003, 42:1004-1013.
16. Lai J.C.K., Tranfield E.M., Walker D.C., Dyck J., Kerjner A., Loo S., et al. Ultrastructural evidence of early endothelial damage in coronary arteries of rat cardiac allografts. J. Heart Lung Transplant 2003, 22:993-1004.
17. Leiper J., Nandi M. The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis. Nat. Rev. Drug Discov. 2011, 10:277.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folinphenol reagent. J. Biol. Chem. 1951, 193:265-275.
19. Luo H.L., Zang W.J., Lu J., Yu X.J., Lin Y.X., Cao Y.X. The protective effect of captopril on nicotine-induced endothelial dysfunction in rats. Basic Clin. Pharmacol. Toxicol. 2006, 99:237-245.
20. Nakagami H., Kaneda Y., Ogihara T., Morishita R. Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. Curr. Diabet. Rev. 2005, 1:59-63.
21. Neunteufl T., Heher S., Kostner K., Mitulovic G., Lehr S., Khoschsorur G., et al. Contribution of nicotine to acute endothelial dysfunction in long-term smokers. J. Am. Coll. Cardiol. 2002, 39:251-256.
22. Okayasu, Tomizawa A., Suzuki K., Manaka K., Hattori Y. PPARα activators upregulate eNOS activity and inhibit cytokine-induced NF-κB activation through AMP-activated protein kinase activation. Life Sci. 2008, 82:884-891.
23. Sainani G.S., Maru V.G. Role of endothelial cell dysfunction in essential hypertension. J. Assoc. Physicians India 2004, 52:966-969.
24. Shah D.I., Singh M. Possible role of exogenous cAMP to improve vascular endothelial dysfunction in hypertensive rats. Fundam. Clin. Pharmacol. 2006, 20:595-04.
25. Shah D.I., Singh M. Effect of bis (maltola) oxovanidium on experimental endothelial dysfunction. Nayunyn-Schmiedeberg's Arch. Pharmacol. 2006, 373:221-229.
26. Shah D.I., Singh M. Possible role of Akt to improve vascular endothelial dysfunction in diabetic and hyperhomocysteinemic rats. Mol. Cell. Biochem. 2007, 295:65-74.
27. Skrha J., Tulcb T., Hilgertova J., Weiserova H., Kvasnickac J., Ceska R. Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes. Eur. J. Pharmacol. 2004, 193:183-189.
28. Sotomayor Ma, Mingorance C., Andriantsitohaina R. Fenofibrate improves age-related endothelial dysfunction in rat resistance arteries. Athero 2007, 193:112-120.
29. Tanus-Santos J.E., Toledo J.C.Y., Cittadino M. Cardiovascular effects of transdermal nicotine in mildly hypertensive smokers. Am. J. Hypertens. 2001, 14:610-614.
30. Van Heerebeek L., Meischl C., Stooker W., Meijer C.J.L.M., Niessen H.W.M., Ross D. NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?. J. Clin. Pathol. 2002, 55:561-568.
31. Zalba G., Beaumont F.J., San Jose G., Fortuno A., Fortuno M.A., Etayo J.C., Diez J. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension 2000, 35:1055-1061.