Redox-sensitive sulfenic acid modification regulates surface expression of the cardiovascular voltage-gated potassium channel Kv1.5

Circulation Research

Volumn 111, Issue 7, 2012, Pages 842-853

  Svoboda, Laurie K ^a,c   Reddie, Khalilah G ^b   Zhang, Lian ^c   Vesely, Eileen D ^c   Williams, Elizabeth S ^c   Schumacher, Sarah M ^c   O'Connell, Ryan P ^c   Shaw, Robin ^d   Day, Sharlene M ^c   Anumonwo, Justus M ^c   Carroll, Kate S ^b,e   Martens, Jeffrey R ^c  

^a UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

atrial fibrillation; Kv1.5; oxidative stress; posttranslational modification; sulfenic acid; trafficking; voltage gated potassium channels

Indexed keywords

CYSTEINE; HORSERADISH PEROXIDASE; POTASSIUM CHANNEL KV1.5; STREPTAVIDIN; SULFENIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; HEART ATRIUM FIBRILLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; INTERNALIZATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROCESSING; RAT; VOLTAGE CLAMP; WESTERN BLOTTING; WHOLE CELL;

AMINO ACID SEQUENCE; ANIMALS; ATRIAL FIBRILLATION; CASE-CONTROL STUDIES; CELL LINE; CELLS, CULTURED; HUMANS; KV1.5 POTASSIUM CHANNEL; MICE; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SULFENIC ACIDS;

EID: 84866537307     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.263525     Document Type: Article

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