S-acylation regulates Kv1.5 channel surface expression

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 1, 2007, Pages

  Zhang, Lian ^a   Foster, Karyn ^a   Li, Qiuju ^a   Martens, Jeffrey R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Channels; Palmitoylation; Posttranslational; Potassium; Quality control

Indexed keywords

CYSTEINE; HYDROXYLAMINE; POTASSIUM CHANNEL KV1.5; PROTEASOME INHIBITOR; THIOESTER;

ACYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL COMPARTMENTALIZATION; CELL SURFACE; CHEMICAL BOND; CONTROLLED STUDY; FIBROBLAST; GENETIC TRANSFECTION; MOUSE; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TARGETING; SENSITIVITY ANALYSIS; STEADY STATE;

ACYLATION; CELL LINE; CELL MEMBRANE; CERULENIN; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; FIBROBLASTS; GLYCOSYLATION; HUMANS; HYDROXYLAMINE; ION CHANNEL GATING; KV1.5 POTASSIUM CHANNEL; MUTATION; PALMITATES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; SULFHYDRYL COMPOUNDS; TIME FACTORS; TRANSFECTION;

EID: 34547103749     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00480.2006     Document Type: Article

References (47)

1. Angulo E, Noe V, Casado V, Mallol J, Gomez-Isla T, Lluis C, Ferrer I, Ciudad CJ, Franco R. Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. J Neurochem 91: 547-557, 2004.
2. + channels? Circ Res 77: 361-369, 1995.
3. Bijlmakers MJ, Marsh M. The on-off story of protein palmitoylation. Trends Cell Biol 13: 32-42, 2003.
4. Brevnova EE, Platoshyn O, Zhang S, Yuan JX. Overexpression of human KCNA5 increases IK V and enhances apoptosis. Am J Physiol Cell Physiol 287: C715-C722, 2004.
5. Chen TT, Luykenaar KD, Walsh EJ, Walsh MP, Cole WC. Key role of Kv1 channels in vasoregulation. Circ Res 99: 53-60, 2006.
6. Chien AJ, Carr KM, Shirokov RE, Rios E, Hosey MM. Identification of palmitoylation sites within the L-type calcium channel beta2a subunit and effects on channel function. J Biol Chem 271: 26465-26468, 1996.
7. Coleman RA, Rao P, Fogelsong RJ, Bardes ES. 2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes. Biochim Biophys Acta 1125: 203-209, 1992.
8. DeJesus G, Bizzozero OA. Effect of 2-fluoropalmitate, cerulenin and tunicamycin on the palmitoylation and intracellular translocation of myelin proteolipid protein. Neurochem Res 27: 1669-1675, 2002.
9. Deutsch C. Potassium channel ontogeny. Annu Rev Physiol 64: 19-46, 2002.
10. De Vos ML, Lawrence DS, Smith CD. Cellular pharmacology of cerulenin analogs that inhibit protein palmitoylation. Biochem Pharmacol 62: 985-995, 2001.
11. Drisdel RC, Green WN. Labeling and quantifying sites of protein palmitoylation. Biotechniques 36: 276-285, 2004.
12. Drisdel RC, Manzana E, Green WN. The role of palmitoylation in functional expression of nicotinic alpha7 receptors. J Neurosci 24: 10502-10510, 2004.
13. Ficker E, Dennis AT, Wang L, Brown AM. Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ Res 92: e87-e100, 2003.
14. Griffith LC. Potassium channels: the importance of transport signals. Curr Biol 11: R226-R228, 2001.
15. Gubitosi-Klug RA, Mancuso DJ, Gross RW. The human Kv1.1 channel is palmitoylated, modulating voltage sensing: identification of a palmitoylation consensus sequence. Proc Natl Acad Sci USA 102: 5964-5968, 2005.
16. Hessa T, Kim H, Bihlmaier K, Lundin C, Boekel J, Andersson H, Nilsson I, White SH, von Heijne G. Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature 433: 377-381, 2005.
17. + channels is governed by a C-terminal motif. Trends Cardiovasc Med 10: 317-320, 2000.
18. Liang X, Lu Y, Neubert TA, Resh MD. Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species. J Biol Chem 277: 33032-33040, 2002.
19. Liang X, Lu Y, Wilkes M, Neubert TA, Resh MD. The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading. J Biol Chem 279: 8133-8139, 2004.
20. Ma D, Jan LY. ER transport signals and trafficking of potassium channels and receptors. Curr Opin Neurobiol 12: 287-292, 2002.
21. Mackinnon R. Structural biology. Voltage sensor meets lipid membrane. Science 306: 1304-1305, 2004.
22. Martens JR, Navarro-Polanco R, Coppock EA, Nishiyama A, Parshley L, Grobaski TD, Tamkun MM. Differential targeting of Shaker-like potassium channels to lipid rafts. J Biol Chem 275: 7443-7446, 2000.
23. Martens JR, O'Connell K, Tamkun M. Targeting of ion channels to membrane microdomains: localization of KV channels to lipid rafts. Trends Pharmacol Sci 25: 16-21, 2004.
24. + channels to distinct lipid raft populations. Targeting of Kv15 to caveolae. J Biol Chem 276: 8409-8414, 2001.
25. + channel protein in explanted cardiac tissue. J Clin Invest 96: 282-292, 1995.
26. Mitchell DA, Vasudevan A, Linder ME, Deschenes RJ. Protein palmitoylation by a family of DHHC protein S-acyltransferases. J Lipid Res 47: 1118-1127, 2006.
27. Nerbonne JM, Kass RS. Molecular physiology of cardiac repolarization. Physiol Rev 85: 1205-1253, 2005.
28. + channels by membrane lipids. Science 304: 265-270, 2004.
29. Paige LA, Zheng GQ, DeFrees SA, Cassady JM, Geahlen RL. S-(2-oxopentadecyl)-CoA, a nonhydrolyzable analogue of myristoyl-CoA, is a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase. J Med Chem 32: 1665-1667, 1989.
30. Paige LA, Zheng GQ, DeFrees SA, Cassady JM, Geahlen RL. Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase. Biochemistry 29: 10566-10573, 1990.
31. Percherancier Y, Planchenault T, Valenzuela-Fernandez A, Virelizier JL, Arenzana-Seisdedos F, Bachelerie F. Palmitoylation-dependent control of degradation, life span, and membrane expression of the CCR5 receptor. J Biol Chem 276: 31936-31944, 2001.
32. Qanbar R, Bouvier M. Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function. Pharmacol Ther 97: 1-33, 2003.
33. Resh MD. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta 1451: 1-16, 1999.
34. Reverey H, Veit M, Ponimaskin E, Schmidt MF. Differential fatty acid selection during biosynthetic S-acylation of a transmembrane protein (HEF) and other proteins in insect cells (Sf9) and in mammalian cells (CV1). J Biol Chem 271: 23607-23610, 1996.
35. Schlesinger MJ, Malfer C. Cerulenin blocks fatty acid acylation of glycoproteins and inhibits vesicular stomatitis and Sindbis virus particle formation. J Biol Chem 257: 9887-9890, 1982.
36. Schmidt JW, Catterall WA. Palmitylation, sulfation, and glycosylation of the alpha subunit of the sodium channel. Role of post-translational modifications in channel assembly. J Biol Chem 262: 13713-13723, 1987.
37. + channels. Biochemistry 35: 12133-12140, 1996.
38. Scott DB, Blanpied TA, Ehlers MD. Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors. Neuropharmacology 45: 755-767, 2003.
39. Smotrys JE, Linder ME. Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem 73: 559-587, 2004.
40. Stockli J, Rohrer J. The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes. Mol Biol Cell 15: 2617-2626, 2004.
41. Takimoto K, Yang EK, Conforti L. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. J Biol Chem 277: 26904-26911, 2002.
42. Tanabe Y, Hatada K, Naito N, Aizawa Y, Chinushi M, Nawa H, Aizawa Y. Over-expression of Kv1.5 in rat cardiomyocytes extremely shortens the duration of the action potential and causes rapid excitation. Biochem Biophys Res Commun 345: 1116-1121, 2006.
43. Towler DA, Gordon JI, Adams SP, Glaser L. The biology and enzymology of eukaryotic protein acylation. Annu Rev Biochem 57: 69-99, 1988.
44. Trombetta ES, Parodi AJ. Quality control and protein folding in the secretory pathway. Annu Rev Cell Dev Biol 19: 649-676, 2003.
45. van't Hof W, Resh MD. Dual fatty acylation of p59(Fyn) is required for association with the T cell receptor zeta chain through phosphotyrosine-Src homology domain-2 interactions. J Cell Biol 145: 377-389, 1999.
46. Webb Y, Hermida-Matsumoto L, Resh MD. Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J Biol Chem 275: 261-270, 2000.
47. Weir EK, Lopez-Barneo J, Buckler KJ, Archer SL. Acute oxygen-sensing mechanisms. N Engl J Med 353: 2042-2055, 2005.