Mitofusin 2 joins the sarcoplasmic reticulum and mitochondria at the hip to sustain cardiac energetics

Circulation Research

Volumn 111, Issue 7, 2012, Pages 821-823

  Konstantinidis, Klitos ^a,b,c   Lederer, W Jonathan ^d   Rizzuto, Rosario ^e   Kitsis, Richard N ^a,b  

^a ALBERT EINSTEIN CANCER CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; MITOFUSIN 2;

CONGESTIVE CARDIOMYOPATHY; ENDOPLASMIC RETICULUM; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART RATE; HIP; NONHUMAN; PRIORITY JOURNAL; REVIEW; SARCOPLASMIC RETICULUM;

ANIMALS; CALCIUM SIGNALING; ENERGY METABOLISM; GTP PHOSPHOHYDROLASES; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; SARCOPLASMIC RETICULUM;

EID: 84866531043     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.277269     Document Type: Review

References (16)

1. Clapham DE. Calcium signaling. Cell. 2007;131:1047-1058.
2. Chen Y, Csordás G, Jowdy C, Schneider TG, Csordás N, Wang W, Liu Y, Kohlhaas M, Meiser M, Bergem S, Nerbonne JM, Dorn GW, Maack C. Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via inter-organelle Ca2 + crosstalk. Circ Res. 2012;111:863-875.
3. McCormack JG, Halestrap AP, Denton RM. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev. 1990;70:391-425.
4. Rizzuto R DSD, Rafaello A, Mammucari C. Mitochondria as sensors and regulators of calcium signaling. Nat Rev Mol Cell Biol. August 1, 2012. doi:10.1038/nrm3412. http://www.nature.com/nrm/journal/vaop/ncurrent/full/ nrm3412.html. Accessed August 22, 2012.
5. De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011;476:336-340.
6. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Kote-liansky V, Mootha VK. Integrative genomics identifies mcu as an essential component of the mitochondrial calcium uniporter. Nature. 2011;476:341-345.
7. Rizzuto R, Brini M, Murgia M, Pozzan T. Microdomains with high ca2 + close to ip3-sensitive channels that are sensed by neighboring mitochondria. Science. 1993;262:744-747.
8. Rizzuto R, Pinton P, Carrington W, Fay FS, Fogarty KE, Lifshitz LM, Tuft RA, Pozzan T. Close contacts with the endoplasmic reticulum as determinants of mitochondrial ca2+ responses. Science. 1998;280:1763-1766.
9. Chikando AC, Kettlewell S, Williams GS, Smith G, Lederer WJ. Ca2 + dynamics in the mitochondria-state of the art. J Mol Cell Cardiol. 2011;51:627-631.
10. Franzini-Armstrong C, Protasi F, Ramesh V. Shape, size, and distribution of ca 2+ release units and couplons in skeletal and cardiac muscles. Biophys J. 1999;77:1528-1539.
11. Williams GS, Chikando AC, Tuan HT, Sobie EA, Lederer WJ, Jafri MS. Dynamics of calcium sparks and calcium leak in the heart. Biophys J. 2011;101:1287-1296.
12. de Brito OM, Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. 2008;456:605-610.
13. Chen Y, Liu Y, Dorn GW II. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circ Res. 2011;109:1327-1331.
14. Papanicolaou KN, Khairallah RJ, Ngoh GA, Chikando A, Luptak I, O'Shea KM, Riley DD, Lugus JJ, Colucci WS, Lederer WJ, Stanley WC, Walsh K. Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Mol Cell Biol. 2011;31:1309-1328.
15. Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW II, O'Rourke B, Kitsis RN. Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci USA. 2012;109:6566-6571.
16. Sobie EA, Guatimosim S, Gomez-Viquez L, Song LS, Hartmann H, Saleet JM, Lederer WJ. The ca(2 +) leak paradox and "rogue ryanodine receptors": Sr ca(2 +) efflux theory and practice. Prog Biophys Mol Biol. 2006;90:172-185.