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Volumn 47, Issue 4, 2012, Pages 701-712

Evaluation of alkylmaltosides as intestinal permeation enhancers: Comparison between rat intestinal mucosal sheets and Caco-2 monolayers

Author keywords

Caco 2 monolayers; Dodecyl maltoside; Intestinal epithelia; Intestinal permeation enhancers; Oral peptide delivery; Tetradecyl maltoside

Indexed keywords

CARBON 14; DODECYL MALTOSIDE; MANNITOL; NONIONIC SURFACTANT; PENETRATION ENHANCING AGENT; TETRADECYL MALTOSIDE; UNCLASSIFIED DRUG;

EID: 84866523389     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.08.010     Document Type: Article
Times cited : (50)

References (50)
  • 1
    • 0035659565 scopus 로고    scopus 로고
    • Enhanced bioavailability of calcitonin formulated with alkylglycosides following nasal and ocular administration in rats
    • F. Ahsan, J. Arnold, E. Meezan, and D.J. Pillion Enhanced bioavailability of calcitonin formulated with alkylglycosides following nasal and ocular administration in rats Pharm. Res. 18 2001 1742 1746
    • (2001) Pharm. Res. , vol.18 , pp. 1742-1746
    • Ahsan, F.1    Arnold, J.2    Meezan, E.3    Pillion, D.J.4
  • 2
    • 0041331765 scopus 로고    scopus 로고
    • Effects of the permeability enhancers, tetradecylmaltoside and dimethyl-beta-cyclodextrin, on insulin movement across human bronchial epithelial cells (16HBE14o-)
    • F. Ahsan, J.J. Arnold, T. Yang, E. Meezan, E.M. Schwiebert, and D.J. Pillion Effects of the permeability enhancers, tetradecylmaltoside and dimethyl-beta-cyclodextrin, on insulin movement across human bronchial epithelial cells (16HBE14o-) Eur. J. Pharm. Sci. 20 2003 27 34
    • (2003) Eur. J. Pharm. Sci. , vol.20 , pp. 27-34
    • Ahsan, F.1    Arnold, J.J.2    Yang, T.3    Meezan, E.4    Schwiebert, E.M.5    Pillion, D.J.6
  • 3
    • 4344705585 scopus 로고    scopus 로고
    • Correlation of tetradecylmaltoside induced increases in nasal peptide drug delivery with morphological changes in nasal epithelial cells
    • J.J. Arnold, F. Ahsan, E. Meezan, and D.J. Pillion Correlation of tetradecylmaltoside induced increases in nasal peptide drug delivery with morphological changes in nasal epithelial cells J. Pharm. Sci. 93 2004 2205 2213
    • (2004) J. Pharm. Sci. , vol.93 , pp. 2205-2213
    • Arnold, J.J.1    Ahsan, F.2    Meezan, E.3    Pillion, D.J.4
  • 4
    • 77949869502 scopus 로고    scopus 로고
    • Reestablishment of the nasal permeability barrier to several peptides following exposure to the absorption enhancer tetradecyl-beta-d-maltoside
    • J.J. Arnold, M.D. Fyrberg, E. Meezan, and D.J. Pillion Reestablishment of the nasal permeability barrier to several peptides following exposure to the absorption enhancer tetradecyl-beta-d-maltoside J. Pharm. Sci. 99 2010 1912 1920
    • (2010) J. Pharm. Sci. , vol.99 , pp. 1912-1920
    • Arnold, J.J.1    Fyrberg, M.D.2    Meezan, E.3    Pillion, D.J.4
  • 5
    • 0025311288 scopus 로고
    • Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
    • P. Artursson Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells J. Pharm. Sci. 79 1990 476 482
    • (1990) J. Pharm. Sci. , vol.79 , pp. 476-482
    • Artursson, P.1
  • 6
    • 0028215122 scopus 로고
    • Site-dependence and structure-effect relationships for alkylglycosides as transmucosal absorption promoters for insulin
    • B.J. Aungst Site-dependence and structure-effect relationships for alkylglycosides as transmucosal absorption promoters for insulin Int. J. Pharm. 105 1994 219 225
    • (1994) Int. J. Pharm. , vol.105 , pp. 219-225
    • Aungst, B.J.1
  • 7
    • 0033816196 scopus 로고    scopus 로고
    • Intestinal permeation enhancers
    • B.J. Aungst Intestinal permeation enhancers J. Pharm. Sci. 89 2000 429 442
    • (2000) J. Pharm. Sci. , vol.89 , pp. 429-442
    • Aungst, B.J.1
  • 8
    • 84857617880 scopus 로고    scopus 로고
    • Absorption enhancers: Applications and advances
    • B.J. Aungst Absorption enhancers: applications and advances AAPS J. 14 2012 10 18
    • (2012) AAPS J. , vol.14 , pp. 10-18
    • Aungst, B.J.1
  • 9
    • 1842689081 scopus 로고    scopus 로고
    • Chemical structure, surface properties and biological activities of the biosurfactant produced by Pseudomonas aeruginosa LBI from soapstock
    • M. Benincasa, A. Abalos, I. Oliveira, and A. Manresa Chemical structure, surface properties and biological activities of the biosurfactant produced by Pseudomonas aeruginosa LBI from soapstock Biomed. Life Sci. 85 2004 1 8
    • (2004) Biomed. Life Sci. , vol.85 , pp. 1-8
    • Benincasa, M.1    Abalos, A.2    Oliveira, I.3    Manresa, A.4
  • 10
    • 84880335982 scopus 로고    scopus 로고
    • CriticalSorb® promotes permeation of flux markers across isolated rat intestinal mucosae and caco-2 monolayers
    • D.J. Brayden, V.A. Bzik, A.L. Lewis, and L. Illum CriticalSorb® promotes permeation of flux markers across isolated rat intestinal mucosae and caco-2 monolayers Pharm. Res. 64 2012 644 653
    • (2012) Pharm. Res. , vol.64 , pp. 644-653
    • Brayden, D.J.1    Bzik, V.A.2    Lewis, A.L.3    Illum, L.4
  • 11
    • 17844406157 scopus 로고    scopus 로고
    • Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: A target for drug delivery
    • M.J. Cano-Cebrian, T. Zornoza, L. Granero, and A. Polache Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery Curr. Drug Deliv. 2 2005 9 22
    • (2005) Curr. Drug Deliv. , vol.2 , pp. 9-22
    • Cano-Cebrian, M.J.1    Zornoza, T.2    Granero, L.3    Polache, A.4
  • 13
    • 0020042466 scopus 로고
    • Kinins stimulate net chloride secretion by the rat colon
    • A.W. Cuthbert, and H.S. Margolius Kinins stimulate net chloride secretion by the rat colon Br. J. Pharmacol. 75 1982 587 598
    • (1982) Br. J. Pharmacol. , vol.75 , pp. 587-598
    • Cuthbert, A.W.1    Margolius, H.S.2
  • 14
    • 1542509564 scopus 로고    scopus 로고
    • The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability
    • A. D'Emanuele, R. Jevprasesphant, J. Penny, and D. Attwood The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability J. Control. Rel. 2004 447 453
    • (2004) J. Control. Rel. , pp. 447-453
    • D'Emanuele, A.1    Jevprasesphant, R.2    Penny, J.3    Attwood, D.4
  • 15
    • 77955841265 scopus 로고    scopus 로고
    • Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate
    • A. Dube, J.A. Nicolazzo, and I. Larson Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate Eur. J. Pharm. Sci. 41 2010 219 225
    • (2010) Eur. J. Pharm. Sci. , vol.41 , pp. 219-225
    • Dube, A.1    Nicolazzo, J.A.2    Larson, I.3
  • 16
    • 23144460688 scopus 로고    scopus 로고
    • In vitro assessment of alkylglycosides as permeability enhancers
    • J.G. Eley, and P. Triumalashetty In vitro assessment of alkylglycosides as permeability enhancers AAPS PharmSciTech 2 2001 E19
    • (2001) AAPS PharmSciTech , vol.2 , pp. 19
    • Eley, J.G.1    Triumalashetty, P.2
  • 17
    • 14044266767 scopus 로고    scopus 로고
    • Effects of temperature, salt, and deuterium oxide on the self-aggregation of alkylglycosides in dilute solution. 2. n- Tetradecyl-beta-d-maltoside
    • C.A. Ericsson, O. Soderman, V.M. Garamus, M. Bergstrom, and S. Ulvenlund Effects of temperature, salt, and deuterium oxide on the self-aggregation of alkylglycosides in dilute solution. 2. n- Tetradecyl-beta-d-maltoside Langmuir 21 2005 1507 1515
    • (2005) Langmuir , vol.21 , pp. 1507-1515
    • Ericsson, C.A.1    Soderman, O.2    Garamus, V.M.3    Bergstrom, M.4    Ulvenlund, S.5
  • 18
    • 15044359147 scopus 로고    scopus 로고
    • Improvement of absorption enhancing effects of n-dodecyl-beta-d- maltopyranoside by its colon-specific delivery using chitosan capsules
    • G. Fetih, S. Lindberg, K. Itoh, N. Okada, T. Fujita, F. Habib, P. Artersson, M. Attia, and A. Yamamoto Improvement of absorption enhancing effects of n-dodecyl-beta-d-maltopyranoside by its colon-specific delivery using chitosan capsules Int. J. Pharm. 293 2005 127 135
    • (2005) Int. J. Pharm. , vol.293 , pp. 127-135
    • Fetih, G.1    Lindberg, S.2    Itoh, K.3    Okada, N.4    Fujita, T.5    Habib, F.6    Artersson, P.7    Attia, M.8    Yamamoto, A.9
  • 19
    • 38449084547 scopus 로고    scopus 로고
    • Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
    • I. Hubatsch, E.G.E. Ragnarsson, and P. Arthursson Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers Nat. Protoc. 2 2007 2111 2119
    • (2007) Nat. Protoc. , vol.2 , pp. 2111-2119
    • Hubatsch, I.1    Ragnarsson, E.G.E.2    Arthursson, P.3
  • 20
    • 21444438059 scopus 로고    scopus 로고
    • Regional differences in P-glycoproteon function in rat intestine
    • A. Iida, M. Tomita, and M. Hayashi Regional differences in P-glycoproteon function in rat intestine Drug. Metab. Pharmacokinet. 20 2005 100 106
    • (2005) Drug. Metab. Pharmacokinet. , vol.20 , pp. 100-106
    • Iida, A.1    Tomita, M.2    Hayashi, M.3
  • 21
    • 84862676295 scopus 로고    scopus 로고
    • Nasal drug delivery - Recent developments and future prospects
    • (PMID 22300620)
    • L. Illum Nasal drug delivery - recent developments and future prospects J. Control. Rel. 2012 (PMID 22300620)
    • (2012) J. Control. Rel.
    • Illum, L.1
  • 22
    • 0034027744 scopus 로고    scopus 로고
    • Evaluation of absorption enhancement for a potent cyclopeptidic alpha(nu)beta(3)-antagonist in a human intestinal cell line (Caco-2)
    • W. Kamm, A. Jonczyk, T. Jung, G. Luckenbach, P. Raddatz, and T. Kissel Evaluation of absorption enhancement for a potent cyclopeptidic alpha(nu)beta(3)-antagonist in a human intestinal cell line (Caco-2) Eur. J. Pharm. Sci. 10 2000 205 214
    • (2000) Eur. J. Pharm. Sci. , vol.10 , pp. 205-214
    • Kamm, W.1    Jonczyk, A.2    Jung, T.3    Luckenbach, G.4    Raddatz, P.5    Kissel, T.6
  • 23
    • 74749108546 scopus 로고    scopus 로고
    • Oral delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, in male Swiss Webster mice. A study comparing the pharmacokinetics of oral delivery to intraperitoneal, subcutaneous, intramuscular, and intranasal administration
    • D.W. Lee, M.C. Leinung, and P. Grasso Oral delivery of mouse [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, in male Swiss Webster mice. A study comparing the pharmacokinetics of oral delivery to intraperitoneal, subcutaneous, intramuscular, and intranasal administration Regul. Peptides 160 2010 129 132
    • (2010) Regul. Peptides , vol.160 , pp. 129-132
    • Lee, D.W.1    Leinung, M.C.2    Grasso, P.3
  • 24
    • 39049193678 scopus 로고    scopus 로고
    • Intravail: Highly effective intranasal delivery of peptide and protein drugs
    • E.T. Maggio Intravail: highly effective intranasal delivery of peptide and protein drugs Expert Opin. Drug Deliv. 3 2006 529 539
    • (2006) Expert Opin. Drug Deliv. , vol.3 , pp. 529-539
    • Maggio, E.T.1
  • 25
    • 79953171104 scopus 로고    scopus 로고
    • Oral delivery of octreotide acetate in Intravail® improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss Webster mice
    • E.T. Maggio, and P. Grasso Oral delivery of octreotide acetate in Intravail® improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss Webster mice Regul. Peptides 167 2011 233 238
    • (2011) Regul. Peptides , vol.167 , pp. 233-238
    • Maggio, E.T.1    Grasso, P.2
  • 26
    • 84866723704 scopus 로고    scopus 로고
    • Overcoming poor permeability: Translating permeation enhancers for oral peptide delivery
    • DDDTEC-289 9
    • Maher, S., Brayden, D.J., 2012. Overcoming poor permeability: translating permeation enhancers for oral peptide delivery. Drug Disc. Today: Technol. DDDTEC-289 9, e-113-e119.
    • (2012) Drug Disc. Today: Technol.
    • Maher, S.1    Brayden, D.J.2
  • 27
    • 43249118993 scopus 로고    scopus 로고
    • Cracking the junction: Update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drugs
    • S. Maher, D.J. Brayden, L. Feighery, and S. McClean Cracking the junction: update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drugs Crit. Rev. Ther. Drug Carrier Syst. 25 2008 117 168
    • (2008) Crit. Rev. Ther. Drug Carrier Syst. , vol.25 , pp. 117-168
    • Maher, S.1    Brayden, D.J.2    Feighery, L.3    McClean, S.4
  • 28
    • 70349843043 scopus 로고    scopus 로고
    • Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae
    • S. Maher, R. Kennelly, V.A. Bzik, A.W. Baird, X. Wang, D. Winter, and D.J. Brayden Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae Eur. J. Pharm. Sci. 38 2009 291 300
    • (2009) Eur. J. Pharm. Sci. , vol.38 , pp. 291-300
    • Maher, S.1    Kennelly, R.2    Bzik, V.A.3    Baird, A.W.4    Wang, X.5    Winter, D.6    Brayden, D.J.7
  • 29
    • 71549130146 scopus 로고    scopus 로고
    • Safety and efficacy of sodium caprate in promoting oral drug absorption: From in vitro to the clinic
    • S. Maher, T.W. Leonard, J. Jacobsen, and D.J. Brayden Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic Adv. Drug Deliv. Rev. 61 2009 1427 1449
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1427-1449
    • Maher, S.1    Leonard, T.W.2    Jacobsen, J.3    Brayden, D.J.4
  • 30
    • 78651228118 scopus 로고    scopus 로고
    • A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa
    • A. Makhlof, M. Werle, Y. Tozuka, and H. Takeuchi A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa J. Control. Rel. 149 2011 81 88
    • (2011) J. Control. Rel. , vol.149 , pp. 81-88
    • Makhlof, A.1    Werle, M.2    Tozuka, Y.3    Takeuchi, H.4
  • 32
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 33
    • 0026547365 scopus 로고
    • Assessment of enhancing ability of medium-chain alkyl saccharides as new absorption enhancers in rat rectum
    • M. Murakami, Y. Kusanoi, K. Takada, and S. Muranishi Assessment of enhancing ability of medium-chain alkyl saccharides as new absorption enhancers in rat rectum Int. J. Pharm. 79 1992 159 169
    • (1992) Int. J. Pharm. , vol.79 , pp. 159-169
    • Murakami, M.1    Kusanoi, Y.2    Takada, K.3    Muranishi, S.4
  • 34
    • 1542724890 scopus 로고    scopus 로고
    • Chain length-dependent effects of alkylmaltosides on nasal absorption of enoxaparin
    • F. Mustafa, T. Yang, M.A. Khan, and F. Ahsan Chain length-dependent effects of alkylmaltosides on nasal absorption of enoxaparin J. Pharm. Sci. 93 2004 675 683
    • (2004) J. Pharm. Sci. , vol.93 , pp. 675-683
    • Mustafa, F.1    Yang, T.2    Khan, M.A.3    Ahsan, F.4
  • 35
    • 0037310763 scopus 로고    scopus 로고
    • Regional intestinal absorption of FITC-dextran 4400 with nanoparticles based on beta-sitosterol beta-D-glucoside in rats
    • K. Nakamura, K. Takayama, T. Nagai, and Y. Maitani Regional intestinal absorption of FITC-dextran 4400 with nanoparticles based on beta-sitosterol beta-D-glucoside in rats J. Pharm. Sci. 92 2003 311 318
    • (2003) J. Pharm. Sci. , vol.92 , pp. 311-318
    • Nakamura, K.1    Takayama, K.2    Nagai, T.3    Maitani, Y.4
  • 38
    • 0036284795 scopus 로고    scopus 로고
    • Synthetic long-chain alkyl maltosides and alkyl sucrose esters as enhancers of nasal insulin absorption
    • D.J. Pillion, F. Ahsan, J.J. Arnold, B.M. Balusubramanian, O. Piraner, and E. Meezan Synthetic long-chain alkyl maltosides and alkyl sucrose esters as enhancers of nasal insulin absorption J. Pharm. Sci. 91 2002 1456 1462
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1456-1462
    • Pillion, D.J.1    Ahsan, F.2    Arnold, J.J.3    Balusubramanian, B.M.4    Piraner, O.5    Meezan, E.6
  • 39
    • 0032904840 scopus 로고    scopus 로고
    • Evaluation of viability of excised rat intestinal segments in the Ussing chamber: Investigation of morphology, electrical parameters, and permeability characteristics
    • B.I. Polentarutti, A.L. Peterson, A.K. Sjoberg, E.K. Anderberg, L.M. Utter, and A.L. Ungell Evaluation of viability of excised rat intestinal segments in the Ussing chamber: investigation of morphology, electrical parameters, and permeability characteristics Pharm. Res. 16 1999 446 454
    • (1999) Pharm. Res. , vol.16 , pp. 446-454
    • Polentarutti, B.I.1    Peterson, A.L.2    Sjoberg, A.K.3    Anderberg, E.K.4    Utter, L.M.5    Ungell, A.L.6
  • 40
    • 77955278701 scopus 로고    scopus 로고
    • High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures
    • L.A. Rawlinson, P.J. O'Brien, and D.J. Brayden High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures J. Control. Rel. 146 2010 84 92
    • (2010) J. Control. Rel. , vol.146 , pp. 84-92
    • Rawlinson, L.A.1    O'Brien, P.J.2    Brayden, D.J.3
  • 41
    • 1842534232 scopus 로고    scopus 로고
    • Cytotoxicity evaluation of enzyme inhibitors and absorption enhancers in Caco-2 cells for oral delivery of salmon calcitonin
    • R.B. Shah, A. Palamakula, and M.A. Khan Cytotoxicity evaluation of enzyme inhibitors and absorption enhancers in Caco-2 cells for oral delivery of salmon calcitonin J. Pharm. Sci. 93 2004 1070 1082
    • (2004) J. Pharm. Sci. , vol.93 , pp. 1070-1082
    • Shah, R.B.1    Palamakula, A.2    Khan, M.A.3
  • 42
    • 0028934442 scopus 로고
    • Characterization of drug transport through tight-junctional pathway in Caco-2 monolayer: Comparison with isolated rat jejunum and colon
    • Y. Tanaka, Y. Taki, T. Sakane, T. Nadai, H. Sezaki, and S. Yamashita Characterization of drug transport through tight-junctional pathway in Caco-2 monolayer: comparison with isolated rat jejunum and colon Pharm. Res. 12 1995 523 528
    • (1995) Pharm. Res. , vol.12 , pp. 523-528
    • Tanaka, Y.1    Taki, Y.2    Sakane, T.3    Nadai, T.4    Sezaki, H.5    Yamashita, S.6
  • 43
    • 0037308398 scopus 로고    scopus 로고
    • A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes
    • K. Tsutsumi, S.K. Li, A.H. Ghanem, N.F.H. Ho, and W.I. Higuchi A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes J. Pharm. Sci. 92 2003 344 359
    • (2003) J. Pharm. Sci. , vol.92 , pp. 344-359
    • Tsutsumi, K.1    Li, S.K.2    Ghanem, A.H.3    Ho, N.F.H.4    Higuchi, W.I.5
  • 44
    • 0033456147 scopus 로고    scopus 로고
    • Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-beta-d-maltopyranoside
    • T. Uchiyama, T. Sugiyama, Y.S. Quan, A. Kotani, N. Okada, T. Fujita, S. Muranishi, and A. Yamamoto Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-beta-d-maltopyranoside J. Pharm. Pharmacol. 51 1999 1241 1250
    • (1999) J. Pharm. Pharmacol. , vol.51 , pp. 1241-1250
    • Uchiyama, T.1    Sugiyama, T.2    Quan, Y.S.3    Kotani, A.4    Okada, N.5    Fujita, T.6    Muranishi, S.7    Yamamoto, A.8
  • 45
    • 0031946994 scopus 로고    scopus 로고
    • Membrane transport of drugs in different regions of the intestinal tract of the rat
    • A.L. Ungell, S. Nylander, S. Bergstrand, A. Sjoberg, and H. Lennernas Membrane transport of drugs in different regions of the intestinal tract of the rat J. Pharm. Sci. 87 1998 360 366
    • (1998) J. Pharm. Sci. , vol.87 , pp. 360-366
    • Ungell, A.L.1    Nylander, S.2    Bergstrand, S.3    Sjoberg, A.4    Lennernas, H.5
  • 46
    • 0036373335 scopus 로고    scopus 로고
    • Morphological and biochemical aspects of apoptosis, oncosis and necrosis
    • C.S. Van, and W. Van Den Broeck Morphological and biochemical aspects of apoptosis, oncosis and necrosis Anat. Histol. Embryol. 31 2002 214 223
    • (2002) Anat. Histol. Embryol. , vol.31 , pp. 214-223
    • Van, C.S.1    Van Den Broeck, W.2
  • 48
    • 80051552613 scopus 로고    scopus 로고
    • High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs
    • E.G. Walsh, S. Maher, M. Devocelle, P.J. O'Brien, A.W. Baird, and D.J. Brayden High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs Peptides 32 2011 1764 1773
    • (2011) Peptides , vol.32 , pp. 1764-1773
    • Walsh, E.G.1    Maher, S.2    Devocelle, M.3    O'Brien, P.J.4    Baird, A.W.5    Brayden, D.J.6
  • 49
    • 14644424682 scopus 로고    scopus 로고
    • Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin
    • T. Yang, J.J. Arnold, and F. Ahsan Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin J. Drug Target 13 2005 29 38
    • (2005) J. Drug Target , vol.13 , pp. 29-38
    • Yang, T.1    Arnold, J.J.2    Ahsan, F.3
  • 50


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