Hepatic iron deposition does not predict extrahepatic iron loading in mouse models of hereditary hemochromatosis

American Journal of Pathology

Volumn 181, Issue 4, 2012, Pages 1173-1179

  Subramaniam, V Nathan ^a,b   McDonald, Cameron J ^a   Ostini, Lesa ^a   Lusby, Patricia E ^a   Wockner, Leesa F ^a   Ramm, Grant A ^a,b   Wallace, Daniel F ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

IRON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBROSIS; GENE EXPRESSION; GENOTYPE; HEART; HEMOCHROMATOSIS; LIVER; MALE; MOUSE; NONHUMAN; PANCREAS; PREDICTOR VARIABLE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN; WILD TYPE;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; IRON; LIVER; LIVER CIRRHOSIS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MYOCARDIUM; ORGAN SPECIFICITY; PANCREAS; RECEPTORS, TRANSFERRIN; RNA, MESSENGER;

EID: 84866517414     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.06.025     Document Type: Article

References (30)

1. D.F. Wallace, V.N. Subramaniam Non-HFE haemochromatosis World J Gastroenterol 13 2007 4690 4698 (Pubitemid 47455559)
2. T. Ganz Hepcidin and iron regulation, 10 years later Blood 117 2011 4425 4433
3. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, D.M. Ward, T. Ganz, J. Kaplan Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090 2093 (Pubitemid 40007660)
4. K.J. Allen, L.C. Gurrin, C.C. Constantine, N.J. Osborne, M.B. Delatycki, A.J. Nicoll, C.E. McLaren, M. Bahlo, A.E. Nisselle, C.D. Vulpe, G.J. Anderson, M.C. Southey, G.G. Giles, D.R. English, J.L. Hopper, J.K. Olynyk, L.W. Powell, D.M. Gertig Iron-overload-related disease in HFE hereditary hemochromatosis N Engl J Med 358 2008 221 230
5. L.M. Fletcher, J.L. Dixon, D.M. Purdie, L.W. Powell, D.H. Crawford Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis Gastroenterology 122 2002 281 289 (Pubitemid 34116981)
6. V. Scotet, M.C. Merour, A.Y. Mercier, B. Chanu, T. Le Faou, O. Raguenes, G. Le Gac, C. Mura, J.B. Nousbaum, C. Ferec Hereditary hemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation Am J Epidemiol 158 2003 129 134 (Pubitemid 36841944)
7. J.E. Cade, J.A. Moreton, B. O'Hara, D.C. Greenwood, J. Moor, V.J. Burley, K. Kukalizch, D.T. Bishop, M. Worwood Diet and genetic factors associated with iron status in middle-aged women Am J Clin Nutr 82 2005 813 820 (Pubitemid 43779695)
8. J. Rochette, G. Le Gac, K. Lassoued, C. Ferec, K.J. Robson Factors influencing disease phenotype and penetrance in HFE haemochromatosis Hum Genet 128 2010 233 248
9. R.V. Andersen, A. Tybjaerg-Hansen, M. Appleyard, H. Birgens, B.G. Nordestgaard Hemochromatosis mutations in the general population: iron overload progression rate Blood 103 2004 2914 2919 (Pubitemid 38451659)
10. J.K. Olynyk, S.E. Hagan, D.J. Cullen, J. Beilby, D.E. Whittall Evolution of untreated hereditary hemochromatosis in the Busselton population: a 17-year study Mayo Clin Proc 79 2004 309 313 (Pubitemid 38269232)
11. L.C. Gurrin, N.J. Osborne, C.C. Constantine, C.E. McLaren, D.R. English, D.M. Gertig, M.B. Delatycki, M.C. Southey, J.L. Hopper, G.G. Giles, G.J. Anderson, J.K. Olynyk, L.W. Powell, K.J. Allen The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis Gastroenterology 135 2008 1945 1952
12. K.R. Bridle, D.M. Frazer, S.J. Wilkins, J.L. Dixon, D.M. Purdie, D.H. Crawford, V.N. Subramaniam, L.W. Powell, G.J. Anderson, G.A. Ramm Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis Lancet 361 2003 669 673 (Pubitemid 36246550)
13. E. Nemeth, A. Roetto, G. Garozzo, T. Ganz, C. Camaschella Hepcidin is decreased in TFR2 hemochromatosis Blood 105 2005 1803 1806 (Pubitemid 40223705)
14. A. Pietrangelo, A. Caleffi, J. Henrion, F. Ferrara, E. Corradini, H. Kulaksiz, W. Stremmel, P. Andreone, C. Garuti Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes Gastroenterology 128 2005 470 479 (Pubitemid 40431098)
15. D.F. Wallace, L. Summerville, E.M. Crampton, D.M. Frazer, G.J. Anderson, V.N. Subramaniam Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload Hepatology 50 2009 1992 2000
16. J.D. Torrance, T.H. Bothwell A simple technique for measuring storage iron concentrations in formalinised liver samples S Afr J Med Sci 33 1968 9 11
17. D.F. Wallace, L. Summerville, P.E. Lusby, V.N. Subramaniam First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin Gut 54 2005 980 986 (Pubitemid 40873913)
18. C.J. McDonald, L. Ostini, D.F. Wallace, A.N. John, D.J. Watters, V.N. Subramaniam Iron loading and oxidative stress in the Atm-/- mouse liver Am J Physiol Gastrointest Liver Physiol 300 2011 G554 G560
19. C.J. McDonald, M.K. Jones, D.F. Wallace, L. Summerville, S. Nawaratna, V.N. Subramaniam Increased iron stores correlate with worse disease outcomes in a mouse model of schistosomiasis infection PLoS One 5 2010 e9594
20. G. Cairo, S. Recalcati, G. Montosi, E. Castrusini, D. Conte, A. Pietrangelo Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis Blood 89 1997 2546 2553 (Pubitemid 27143304)
21. J.E. Levy, L.K. Montross, D.E. Cohen, M.D. Fleming, N.C. Andrews The C282Y mutation causing hereditary hemochromatosis does not produce a null allele Blood 94 1999 9 11 (Pubitemid 29300128)
22. A. Lebeau, J. Frank, H.K. Biesalski, G. Weiss, S.K. Srai, R.J. Simpson, A.T. McKie, S. Bahram, S. Gilfillan, K. Schumann Long-term sequelae of HFE deletion in C57BL/6 × 129/O1a mice, an animal model for hereditary haemochromatosis Eur J Clin Invest 32 2002 603 612 (Pubitemid 36223412)
23. P. Rodrigues, C. Lopes, C. Mascarenhas, P. Arosio, G. Porto, M. De Sousa Comparative study between Hfe-/- and beta2m-/- mice: progression with age of iron status and liver pathology Int J Exp Pathol 87 2006 317 324 (Pubitemid 44049966)
24. V. Niederkofler, R. Salie, S. Arber Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload J Clin Invest 115 2005 2180 2186 (Pubitemid 41134159)
25. M. De Gobbi, A. Roetto, A. Piperno, R. Mariani, F. Alberti, G. Papanikolaou, M. Politou, G. Lockitch, D. Girelli, S. Fargion, T.M. Cox, P. Gasparini, M. Cazzola, C. Camaschella Natural history of juvenile haemochromatosis Br J Haematol 117 2002 973 979 (Pubitemid 34649342)
26. G. Le Gac, F. Mons, S. Jacolot, V. Scotet, C. Ferec, T. Frebourg Early onset hereditary hemochromatosis resulting from a novel TFR2 gene nonsense mutation (R105X) in two siblings of north French descent Br J Haematol 125 2004 674 678 (Pubitemid 38747971)
27. A. Piperno, A. Roetto, R. Mariani, S. Pelucchi, C. Corengia, F. Daraio, A. Piga, G. Garozzo, C. Camaschella Homozygosity for transferrin receptor-2 Y250X mutation induces early iron overload Haematologica 89 2004 359 360 (Pubitemid 38788423)
28. R.D. Delima, A.C. Chua, J.E. Tirnitz-Parker, E.K. Gan, K.D. Croft, R.M. Graham, J.K. Olynyk, D. Trinder Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice Hepatology 56 2012 585 593
29. R.E. Fleming, C.C. Holden, S. Tomatsu, A. Waheed, E.M. Brunt, R.S. Britton, B.R. Bacon, D.C. Roopenian, W.S. Sly Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis Proc Natl Acad Sci U S A 98 2001 2707 2711 (Pubitemid 32209547)
30. L.J. Noetzli, J. Papudesi, T.D. Coates, J.C. Wood Pancreatic iron loading predicts cardiac iron loading in thalassemia major Blood 114 2009 4021 4026