Differential effects of late-life initiation of low-dose enalapril and losartan on diastolic function in senescent Fischer 344×Brown Norway male rats

Age

Volumn 34, Issue 4, 2012, Pages 831-843

  Groban, Leanne ^a   Lindsey, Sarah ^a   Wang, Hao ^a   Lin, Marina S ^a   Kassik, Kimberly A ^a   Machado, Frederico S M ^b   Carter, Christy S ^c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Angiotensin II receptor blocker; Angiotensin converting enzyme inhibitor; Diastolic dysfunction; Oxidative stress; SERCA2; Tissue Doppler

Indexed keywords

3 NITROTYROSINE; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; ENALAPRIL; LOSARTAN; PHOSPHOLAMBAN; RAC1 PROTEIN; REGULATOR PROTEIN; SARCOPLASMIC ENDOPLASMIC RETICULUM CALCIUM ADENOSINE TRIPHOSPHATASE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN NORWAY RAT; CALCIUM CELL LEVEL; CHRONIC DRUG ADMINISTRATION; COLLAGEN METABOLISM; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIASTOLIC DYSFUNCTION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; FISCHER 344 RAT; HEART LEFT VENTRICLE FILLING PRESSURE; HEART MUSCLE RELAXATION; HEART RATE VARIABILITY; LOW DRUG DOSE; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT;

AGING; ANALYSIS OF VARIANCE; ANIMALS; ARTERIAL PRESSURE; DIASTOLE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ECHOCARDIOGRAPHY, DOPPLER; ENALAPRIL; HEART FUNCTION TESTS; HEART RATE; LOSARTAN; MALE; MYOCARDIAL CONTRACTION; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS; RATS, INBRED BN; RATS, INBRED F344; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; VENTRICULAR FUNCTION, LEFT;

EID: 84866504349     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9283-8     Document Type: Article

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