Toll-like receptors in autoimmunity with special reference to systemic lupus erythematosus

Indian Journal of Human Genetics

Volumn 18, Issue 2, 2012, Pages 155-160

  Das, Swaptagni ^a   Ghosh, Kanjaksha ^a   Pradhan, Vandana ^a   Surve, Prathamesh ^a  

^a KEM HOSPITAL   (India)

Author keywords

autoimmunity; systemic lupus erythematosus; Toll like receptors

Indexed keywords

AUTOANTIBODY; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

ANTIBODY PRODUCTION; APOPTOSIS; AUTOIMMUNITY; GENE EXPRESSION; HUMAN; INFLAMMATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 84866490398     PISSN: 09716866     EISSN: 1998362X     Source Type: Journal    
DOI: 10.4103/0971-6866.100750     Document Type: Review

References (22)

1. Janeway CA, Travers P, Walport M, Shlomchik MJ. Immunobiology: The immune system in health and disease. 6th ed. New York: Garland Science; 2005.
2. Singh D, Naik S. The role of toll-like receptors in autoimmune diseases. J Indian Rheumatol Assoc 2005;13:162-5.
3. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005;17:1-14.
4. Roach JC, Glusman G, Kaur A, Purcell MK, Smith KD, Hood LE, et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA 2005;102:9577-82.
5. Husebye H, Halaas O, Stenmark H, Tunheim G, Sandanger O, Bogen B, et al. Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J 2006;25:683-92.
6. Blander JM, Medzhitov R, Regulation of phagosome maturation by signals from toll-like receptors. Science 2004;304:1014-8.
7. Papadimitr aki ED, Bertsias GK, Boumpas DT. Toll like receptors and autoimmunity: A critical appraisal. J Autoimmun 2007;29:310-8.
8. Toubi E, Shoenfeld Y. Toll-like receptors and their role in the development of autoimmune diseases. Autoimmunity 2004;37:183-8.
9. Schnare M, Holt AC, Takeda K, Akira S, Medzhitov R. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol 2000;10:1139-42.
10. Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 2005;202:1171-7.
11. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune diseases. Nat Rev Immunol. 2006;6:823-35.
12. Corr SC, O'Neill LA. Genetic variation in Toll-like receptor signalling and the risk of inflammatory and immune diseases. J Innate Immun 2009;1:350-7.
13. Means TK, Luster AD. Toll-like receptor activation in the pathogenesis of systemic lupus erythematosus. Ann N Y Acad Sci 2005;1062:242-51.
14. Hur JW, Shin HD, Park BL, Kim LH, Kim SY, Bae SC. Association study of Toll-like receptor 9 gene polymorphisms in Korean patients with systemic lupus erythematosus. Tissue Antigens 2005;65:266-70.
15. Tao K, Fujii M, Tsukumo S, Maekawa Y, Kishihara K, Kimoto Y, et al. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. Ann Rheum Dis 2007;66:905-9.
16. Patole PS, Grone HJ, Segere r S, Ciubar R, Belemezova E, Henger A, et al. Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol 2005;16:1326-38.
17. O'Neill LA. Therapeutic targeting of Toll-like receptors for infl ammatory and infectious diseases. Curr Opin in Pharmacol 2003;3:396-403.
18. Hong-Geller E, Chaudhary A, Lauer S. Targeting Toll-like receptor signaling pathways for design of novel immune therapeutics. Curr Drug Discov Technol 2008;5:29-38.
19. Gearing AJ. Targeting toll-like receptors for drug development: A summary of commercial approaches Commercial approaches. Immunol Cell Biol 2007; 85:490- 4.
20. Chua BY, Zeng W, Jackson DC. Synthesis of Toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines. Methods Mol Biol 2008;494:247-61.
21. Tse K, Horner AA. Update on toll-like receptor-directed therapies for human disease. Ann Rheum Dis 2007;66 (Suppl 3):7-80.
22. Krieg AM, Vollmer J. Toll-like receptors 7, 8, and 9: Linking innate immunity to autoimmunity. Immunol Rev 2007;220:251-69.