Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines

Methods in Molecular Biology

Volumn 494, Issue , 2008, Pages 247-261

  Chua, Brendon Y ^a   Zeng, Weiguang ^a   Jackson, David C ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Antibody; ELISA; Immunocontraception; Peptide synthesis; Self adjuvanting lipopeptide

Indexed keywords

ANIMALIA;

EID: 84934444035     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-419-3_14     Document Type: Article

References (35)

1. Deliyannis, G., Jackson, D.C., Ede, N.J., et al. (2002) Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus. J. Virol. 76(9), 4212-4221.
2. Egan, M.A., Chong, S.Y., Hagen, M., et al. (2004) A comparative evaluation of nasal and parenteral vaccine adjuvants to elicit systemic and mucosal HIV-1 peptide-specific humoral immune responses in cynomolgus macaques. Vaccine 22(27-28), 3774-3788.
3. Halassy, B., Mateljak, S., Bouche, F.B., et al. (2006) Immunogenicity of peptides of measles virus origin and influence of adjuvants. Vaccine 24(2), 185-194.
4. Jackson, D.C., Lau, Y.F., Le, T., et al. (2004) A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses. Proc. Natl. Acad. Sci. USA 101(43), 15440-15445.
5. Olive, C., Clair, T., Yarwood, P., and Good, M.F. (2002) Protection of mice from group A streptococcal infection by intranasal immunisation with a peptide vaccine that contains a conserved M protein B cell epitope and lacks a T cell autoepitope. Vaccine 20(21-22), 2816-2825.
6. Taouji, S., Nomura, I., Giguere, S., et al. (2004) Immunogenecity of synthetic peptides representing linear B-cell epitopes of VapA of Rhodococcus equi. Vaccine 22(9-10), 1114-1123.
7. Cassataro, J., Estein, S.M., Pasquevich, K.A., et al. (2005) Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection. Infect. Immun. 73(12), 8079-8088.
8. Ben-Yedidia, T., Tarrab-Hazdai, R., Schechtman, D., and Arnon, R. (1999) Intranasal administration of synthetic recombinant peptide-based vaccine protects mice from infection by Schistosoma mansoni. Infect. Immun. 67(9), 4360-4366.
9. Lougovskoi, A.A., Okoyeh, N.J., and Chauhan, V.S. (1999) Mice immunised with synthetic peptide from N-terminal conserved region of merozoite surface antigen-2 of human malaria parasite Plasmodium falciparum can control infection induced by Plasmodium yoelii yoelii 265BY strain. Vaccine 18(9-10), 920-930.
10. Audran, R., Cachat, M., Lurati, F., et al. (2005) Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen. Infect. Immun. 73(12), 8017-8026.
11. Smith, J.W., 2nd, Walker, E.B., Fox, B.A., et al. (2003) Adjuvant immunization of HLA-A2-positive melanoma patients with a modified gp100 peptide induces peptide-specific CD8+ T-cell responses. J. Clin. Oncol. 21(8), 1562-1573.
12. Valmori, D., Dutoit, V., Ayyoub, M., et al. (2003) Simultaneous CD8+ T cell responses to multiple tumor antigen epitopes in a multipeptide melanoma vaccine. Cancer Immun. 3, 15.
13. Noguchi, M., Itoh, K., Suekane, S., et al. (2004) Phase I trial of patient-oriented vaccination in HLA-A2-positive patients with metastatic hormone-refractory prostate cancer. Cancer Sci. 95(1), 77-84.
14. Chianese-Bullock, K.A., Pressley, J., Garbee, C., et al. (2005) MAGE-A1-, MAGE-A10-, and gp100-derived peptides are immunogenic when combined with granulocyte-macrophage colony-stimulating factor and montanide ISA-51 adjuvant and administered as part of a multipeptide vaccine for melanoma. J. Immunol. 174(5), 3080-3086.
15. Ghosh, S. and Jackson, D.C. (1999) Antigenic and immunogenic properties of totally synthetic peptide-based anti-fertility vaccines. Int. Immunol. 11(7), 1103-1110.
16. Ferro, V.A., Khan, M.A., McAdam, D., et al. (2004) Efficacy of an anti-fertility vaccine based on mammalian gonadotrophin releasing hormone (GnRH-I) - a histological comparison in male animals. Vet. Immunol. Immunopathol. 101(1-2), 73-86.
17. Zeng, W., Ghosh, S., Macris, M., Pagnon, J., and Jackson, D.C. (2001) Assembly of synthetic peptide vaccines by chemoselective ligation of epitopes: influence of different chemical linkages and epitope orientations on biological activity. Vaccine 19(28-29), 3843-3852.
18. Jinshu, X., Jingjing, L., Duan, P., et al. (2005) A synthetic gonadotropin-releasing hormone (GnRH) vaccine for control of fertility and hormone dependent diseases without any adjuvant. Vaccine 23(40), 4834-4843.
19. Mesa, C. and Fernandez, L.E. (2004) Challenges facing adjuvants for cancer immunotherapy. Immunol. Cell Biol. 82(6), 644-650.
20. Pashine, A., Valiante, N.M., and Ulmer, J.B. (2005) Targeting the innate immune response with improved vaccine adjuvants. Nat. Med. 11(4 Suppl), S63-68.
21. BenMohamed, L., Belkaid, Y., Loing, E., Brahimi, K., Gras-Masse, H., and Druilhe, P. (2002) Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant. Eur. J. Immunol. 32(8), 2274-2281.
22. Le Gal, F.A., Prevost-Blondel, A., Lengagne, R., et al. (2002) Lipopeptide-based melanoma cancer vaccine induced a strong MART-27-35-cytotoxic T lymphocyte response in a preclinal study. Int. J. Cancer 98(2), 221-227.
23. Chua, B.Y., Healy, A., Cameron, P.U., et al. (2003) Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus. Immunol. Cell Biol. 81(1), 67-72.
24. Muhlradt, P.F., Kiess, M., Meyer, H., Sussmuth, R., and Jung, G. (1997) Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J. Exp. Med. 185(11), 1951-1958.
25. Zeng, W., Ghosh, S., Lau, Y.F., Brown, L.E., and Jackson, D.C. (2002) Highly immunogenic and totally synthetic lipopeptides as self-adjuvanting immunocontraceptive vaccines. J. Immunol. 169(9), 4905-4912.
26. Nardin, E.H., Calvo-Calle, J.M., Oliveira, G.A., et al. (1998) Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein. Vaccine 16(6), 590-600.
27. Obert, M., Pleuger, H., Hanagarth, H.G., et al. (1998) Protection of mice against SV40 tumours by Pam3Cys, MTP-PE and Pam3Cys conjugated with the SV40 T antigen-derived peptide, K(698)-T(708). Vaccine 16(2-3), 161-169.
28. Mora, A.L. and Tam, J.P. (1998) Controlled lipidation and encapsulation of peptides as a useful approach to mucosal immunizations. J. Immunol. 161(7), 3616-3623.
29. Shimizu, T., Ohtsuka, Y., Yanagihara, Y., Kurimura, M., Takemoto, M., and Achiwa, K. (1991) Comparison of biologic activities of synthetic lipopentapeptide analogs of bacterial lipoprotein in mice. Mol. Biother. 3(1), 46-50.
30. Delves, P.J., Lund, T., and Roitt, I.M. (2002) Antifertility vaccines. Trends Immunol. 23(4), 213-219.
31. Oonk, H.B., Turkstra, J.A., Schaaper, W.M., et al. (1998) New GnRH-like peptide construct to optimize efficient immunocastration of male pigs by immunoneutralization of GnRH. Vaccine 16(11-12), 1074-1082.
32. Ferro, V.A. and Stimson, W.H. (1997) Immunoneutralisation of gonadotrophin releasing hormone: a potential treatment for oestrogen-dependent breast cancer. Eur. J. Cancer 33(9), 1468-1478.
33. Talwar, G.P. (1999) Vaccines and passive immunological approaches for the control of fertility and hormone-dependent cancers. Immunol. Rev. 171, 173-192.
34. Ghosh, S., Walker, J., and Jackson, D.C. (2001) Identification of canine helper T-cell epitopes from the fusion protein of canine distemper virus. Immunology 104(1), 58-66.
35. Wade, J.D., Bedford, J., Sheppard, R.C., and Tregear, G.W. (1991) DBU as an N alpha-deprotecting reagent for the fluorenylmethoxycarbonyl group in continuous flow solid-phase peptide synthesis. Pept. Res. 4(3), 194-199.