Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines

International Journal of Oncology

Volumn 41, Issue 4, 2012, Pages 1520-1530

  Nishimura, Yukio ^a   Takiguchi, Soichi ^b   Yoshioka, Kiyoko ^c   Nakabeppu, Yusaku ^a   Itoh, Kazuyuki ^c  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL KYUSHU CANCER CENTER   (Japan)

^c OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

Endocytosis; Endosomes lysosomes; Gefitinib; Non small cell lung cancer cell lines; Phosphorylated EGF receptor; Sorting nexin 1

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; SMALL INTERFERING RNA; SORTING NEXIN; SORTING NEXIN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; EXPERIMENTAL RABBIT; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LUNG NON SMALL CELL CANCER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; WESTERN BLOTTING;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; ENDOCYTOSIS; ENDOSOMES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYSOSOMES; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SORTING NEXINS;

EID: 84866489642     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1578     Document Type: Article

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