Low frequency of regulatory t cells in the peripheral blood of children with type 1 diabetes diagnosed under the age of five

Archivum Immunologiae et Therapiae Experimentalis

Volumn 60, Issue 4, 2012, Pages 307-313

  Szypowska, Agnieszka ^a   Stelmaszczyk Emmel, Anna ^a   Demkow, Urszula ^a   Luczyński, Wlodzimierz ^b  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

FoxP3; IL 10; TGF ; Tregs

Indexed keywords

C PEPTIDE; CASPASE 3; CD4 ANTIGEN; HEMOGLOBIN A1C; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

AGE; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CHILD; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE COUNT; MALE; ONSET AGE; PATIENT ASSESSMENT; PRESCHOOL CHILD; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY T LYMPHOCYTE; RISK ASSESSMENT; SCHOOL CHILD; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ANTIGENS, CD; C-PEPTIDE; CELL SEPARATION; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFANT; INTERLEUKIN-10; MALE; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84866481452     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-012-0177-y     Document Type: Article

References (26)

1. Abdul-Rasoul M, Habib H, Al-Khouly M (2006) 'The honeymoon phase' in children with type 1 diabetes mellitus: frequency, duration, and influential factors. Pediatr Diabetes 7:101-107
2. Bober E, Dundar B, Buyukgebiz A (2001) Partial remission phase and metabolic control in type 1 diabetes mellitus in children and adolescents. J Pediatr Endocrinol Metab 14:435-441 (Pubitemid 32318359)
3. Bowden SA, Duck MM, Hoffman RP (2008) Young children (\5 yr) and adolescents ([12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor. Pediatr Diabetes 9(Pt 1):197-201 (Pubitemid 351785004)
4. Brusko TM, Wasserfall CH, Clare-Salzler MJ et al (2005) Functional defects and the influence of age on the frequency of CD4?CD25?T-cells in type 1 diabetes. Diabetes 54:1407-1414 (Pubitemid 40586671)
5. Cheatem D, Ganesh BB, Gangi E et al (2009) Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4? CD25?regulatory T cell function. Clin Immunol 131:260-270
6. Chen C, Liu CP (2009) Regulatory function of a novel population of mouse autoantigen-specific Foxp3 regulatory T cells depends on IFN-gamma, NO, and contact with target cells. PLoS ONE 4:e7863
7. Craig M, Hattersley A, Donaghue K (2009) Definition, epidemiology, diagnosis and classification of diabetes in children and adolescents. Pediatr Diabetes 10(suppl 12):3-12
8. Glisic-Milosavljevic S, Wang T, Koppen M et al (2007a) Dynamic changes in CD4?CD25?high T cell apoptosis after the diagnosis of type 1 diabetes. Clin Exp Immunol 150:75-82 (Pubitemid 47383305)
9. Glisic-Milosavljevic S, Waukau J, Jailwala P et al (2007b) At risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4?CD25?high T cell fraction. PLoS ONE 2:e146
10. Greenbaum CJ, Mandrup-Poulsen T, McGee PF et al (2008) Mixedmeal tolerance test versus glucagon stimulation test for the assessment of b-cell function in therapeutic trials in type 1 diabetes. Diabetes Care 31:1966-1971
11. Karges B, Durinovic-Belló I, Heinze E et al (2006) Immunological mechanisms associated with long-term remission of human type 1 diabetes. Diabetes Metab Res Rev 22:184-189 (Pubitemid 43805398)
12. Komulainen J, Lounamaa R, Knip M et al (1996) Ketoacidosis at the diagnosis of type 1 (insulin dependent) diabetes mellitus is related to poor residual cell function. Arch Dis Child 75:410-415 (Pubitemid 26405681)
13. Kukreja A, Cost G, Marker J et al (2002) Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 109:131-140 (Pubitemid 34052549)
14. Lindley S, Dayan CM, Bishop A et al (2005) Defective suppressor function in CD4(?)CD25(?) T-cells from patients with type 1 diabetes. Diabetes 54:92-99 (Pubitemid 40105099)
15. Liu W, Putnam AL, Xu-Yu Z et al (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4?Treg cells. J Exp Med 203:1701-1711 (Pubitemid 44036276)
16. Łuczyński W, Wawrusiewicz-Kurylonek N, Stasiak-Barmuta A et al (2009) Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes. Acta Biochim Pol 56:361-370
17. Patterson CC, Dahlquist GG, Gyürüs E et al (2009) Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study. Lancet 373:2027-2033
18. Perez N, Karumuthil-Melethil S, Li R et al (2008) Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1 (?)-Adaptive regulatory T cell generation. J Immunol 180: 6566-6576
19. Pop SM, Wong CP, Culton DA et al (2005) Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4?CD25?regulatory T cells during autoimmune diabetes. J Exp Med 201:1333-1346 (Pubitemid 40629075)
20. Putnam AL, Vendrame F, Dotta F et al (2005) CD4?CD25high regulatory T cells in human autoimmune diabetes. J Autoimmun 24:55-62 (Pubitemid 40269495)
21. Ryba M, Rybarczyk-Kapturska K, Zorena K et al (2011) Lower frequency of CD62L and higher frequency of TNFR2 Tregs are associated with inflammatory conditions in type 1 diabetic patients. Mediators Inflamm 2011:645643
22. Sanda S, Bart O, Roep BO et al (2008) Islet antigen specific IL-10? immune responses but not CD4?CD25?FoxP3? cells at diagnosis predict glycemic control in type 1 diabetes. Clin Immunol 127:138-143
23. Sojka DK, Huang YH, Fowell DJ (2008) Mechanisms of regulatory T-cell suppression -A diverse arsenal for a moving target. Immunology 124:13-22 (Pubitemid 351537583)
24. Szypowska A, Stelmaszczyk-Emmel A, Demkow U et al (2010) Evaluation of T regulatory cell apoptosis in children with newly recognized type 1 diabetes mellitus. Eur J Med Res 15(suppl 2):198-201
25. Tritt M, Sgouroudis E, d'Hennezel E et al (2008) Functional waning of naturally occurring CD4?regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes 57:113-123
26. Vrabelova Z, Hrotekova Z, Hladikova Z et al (2008) CD127-And FoxP3? expression on CD25?CD4? T regulatory cells upon specific diabetogeneic stimulation in high-risk relatives of type 1 diabetes mellitus patients. Scand J Immunol 67:404-410 (Pubitemid 351409347)