CD 127- and FoxP3+ expression on CD25 +CD4+ T regulatory cells upon specific diabetogeneic stimulation in high-risk relatives of type 1 diabetes mellitus patients

Scandinavian Journal of Immunology

Volumn 67, Issue 4, 2008, Pages 404-410

  Vrabelova, Z ^a,b   Hrotekova, Z ^b   Hladikova, Z ^a   Bohmova, K ^a   Stechova, K ^a   Michalek, J ^b,c  

^a UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

^c UNIVERSITY HOSPITAL BRNO   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BIOLOGICAL MARKER; CYTOKINE; GAMMA INTERFERON; HLA DQA1 ANTIGEN; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL LABELING; CELL STIMULATION; CONTROLLED STUDY; DIABETOGENESIS; HLA SYSTEM; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; RISK FACTOR;

ADOLESCENT; ADULT; ANTIGENS, CD4; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE COUNT; MALE; RISK FACTORS; T-LYMPHOCYTES, REGULATORY;

EID: 40949156299     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2008.02074.x     Document Type: Article

References (34)

1. Bach JF. Autoimmune diseases as the loss of active "self- control". Ann N Y Acad Sci 2003 998 : 161 77.
2. Yi H, Zhen Y, Jiang L, Zheng J, Zhao Y. The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells. Cell Mol Immunol 2006 3 : 189 95.
3. Walker MR, Kasprowicz DJ, Gersuk VH et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 2003 112 : 1437 43.
4. Banham AH, Powrie FM, Suri-Payer E. FOXP3+ regulatory T cells: current controversies and future perspectives. Eur J Immunol 2006 36 : 2832 6.
5. Roep BO. The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure. Diabetologia 2003 46 : 305 21.
6. Tree TI, Peakman M. Autoreactive T cells in human type 1 diabetes. Endocrinol Metab Clin North Am 2004 33 : 113 33.
7. Bluestone JA, Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol 2005 17 : 638 42.
8. Tsutsumi Y, Jie X, Ihara K et al. Phenotypic and genetic analyses of T-cell-mediated immunoregulation in patients with Type 1 diabetes. Diabet Med 2006 23 : 1145 50.
9. Cinek O, Kolouskova S, Pechova M et al. Prediction of insulin-dependent diabetes mellitus in first-degree relatives of diabetic patients. Cas Lek Cesk 2001 140 : 492 6.
10. Yagi H, Nomura T, Nakamura K et al. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 2004 16 : 1643 56.
11. Liu W, Putnam AL, Xu-Yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006 203 : 1701 11.
12. Bettelli E, Dastrange M, Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 2005 102 : 5138 43.
13. Grant C, Oh U, Fugo K et al. Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways. PLoS Pathog 2006 2 : e33.
14. Serfling E, Klein-Hessling S, Palmetshofer A, Bopp T, Stassen M, Schmitt E. NFAT transcription factors in control of peripheral T cell tolerance. Eur J Immunol 2006 36 : 2837 43.
15. Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006 203 : 1693 700.
16. Achenbach P, Warncke K, Reiter J et al. Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives. Diabetologia 2006 49 : 2969 76.
17. Lambert AP, Gillespie KM, Thomson G et al. Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. J Clin Endocrinol Metab 2004 89 : 4037 43.
18. Michalek J, Vrabelova Z, Hrotekova Z et al. Immune regulatory T cells in siblings of children suffering from type 1 diabetes mellitus. Scand J Immunol 2006 64 : 531 5.
19. Schloot NC, Meierhoff G, Karlsson Faresjo M et al. Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop. J Autoimmun 2003 21 : 365 76.
20. Nagata M, Kotani R, Moriyama H, Yokono K, Roep BO, Peakman M. Detection of autoreactive T cells in type 1 diabetes using coded autoantigens and an immunoglobulin-free cytokine ELISPOT assay: report from the fourth immunology of diabetes society T cell workshop. Ann N Y Acad Sci 2004 1037 : 10 5.
21. Peakman M, Tree TI, Endl J, van Endert P, Atkinson MA, Roep BO. Second International Immunology of Diabetes Society Workshop for Standardization ot T-cell Assays in Type 1 Diabetes. Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes. Diabetes 2001 50 : 1749 54.
22. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005 6 : 345 52.
23. Sedlakova N, Praksova P, Pejchlova M, Kovarova L, Hrstkova H, Michalek J. Immunoregulatory T cell defects in children with type 1 diabetes. Cs Pediatr 2005 60 : 183 7 (in Czech, abstract in English).
24. Kukreja A, Cost G, Marker J et al. Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 2002 109 : 131 40.
25. Dejaco C, Duftner C, Grubeck-Loebenstein B, Schirmer M. Imbalance of regulatory T cells in human autoimmune diseases. Immunology 2006 117 : 289 300.
26. Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005 54 : 92 9.
27. Brusko TM, Wasserfall CH, Clare-Salzler MJ, Schatz DA, Atkinson MA. Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes 2005 54 : 1407 14.
28. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995 155 : 1151 64.
29. Tree TI, Roep BO, Peakman M. A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop. Ann N Y Acad Sci 2006 1079 : 9 18.
30. Homann D, Eisenbarth GS. An immunologic homunculus for type 1 diabetes. J Clin Invest 2006 116 : 1212 5.
31. Karlsson MGE, Sederholm Lawesson S, Ludvigsson J. Th1-like dominance in high-risk first-degree relatives of Type I diabetic patients. Diabetologia 2000 43 : 742 9.
32. Larkin J III., Picca CC, Caton AJ. Activation of CD4(+)CD25(+) regulatory T cell suppressor function by analogs of the selecting peptide. Eur J Immunol 2007 37 : 139 46.
33. Fehervari Z, Yamaguchi T, Sakaguchi S. The dichotomous role of IL-2: tolerance versus imunity. Trends Immunol 2006 27 : 109 11. Epub 2006 Feb 3.
34. Brusko T, Wasserfall C, McGrail K et al. No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes. Diabetes 2007 56 : 604 12.