Selective expression of CYP2A13 in human pancreatic α-islet cells

Drug Metabolism and Disposition

Volumn 40, Issue 10, 2012, Pages 1878-1882

  Guo, Yu ^a,b   Zhu, Liang Ru ^c   Lu, Gang ^d   Wang, Hui ^a   Hong, Jun Yan ^b  

^a WUHAN UNIVERSITY   (China)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2A; PROTEIN CYP2A13; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; METABOLIC ACTIVATION; PANCREAS DISEASE; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CARCINOGENS; FLUORESCENT ANTIBODY TECHNIQUE; GLUCAGON-SECRETING CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; PANCREATIC NEOPLASMS; SMOKING; SUBSTRATE SPECIFICITY;

NICOTIANA TABACUM;

EID: 84866468712     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046359     Document Type: Article

References (33)

1. Bao Z, He XY, Ding X, Prabhu S, and Hong JY. (2005) Metabolism of nicotine and cotinine by human cytochrome P450 2A13. Drug Metab Dispos 33:258-261. (Pubitemid 40216593)
2. Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, and Caicedo A (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 103:2334-2339. (Pubitemid 43271670)
3. Chowdhury P, Doi R, Tangoku A, and Rayford PL (1995) Structural and functional changes of rat exocrine pancreas exposed to nicotine. Int J Pancreatol 18:257-264. (Pubitemid 26023508)
4. Ding S, Lake BG, Friedberg T, and Wolf CR (1995) Expression and alternative splicing of the cytochrome P-450 CYP2A7. Biochem J 306:161-166.
5. Ding X and Kaminsky LS (2003) Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 43:149-173. (Pubitemid 37372638)
6. Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, and Idle JR (1995) A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Genet 57:651-660.
7. Fukami T, Katoh M, Yamazaki H, Yokoi T, and Nakajima M (2008) Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene. Chem Res Toxicol 21:720-725. (Pubitemid 351498048)
8. Goldstein JA, Kirwin JD, Seymour NE, Trachtenberg JE, Rademaker EA, and Andersen DK (1989) Reversal of in vitro hepatic insulin resistance in chronic pancreatitis by pancreatic polypeptide in the rat. Surgery 106:1128-1132.
9. Hathout EH, Beeson WL, Ischander M, Rao R, and Mace JW (2006) Air pollution and type 1 diabetes in children. Pediatr Diabetes 7:81-87.
10. He XY, Tang L, Wang SL, Cai QS, Wang JS, and Hong JY (2006) Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract. Int J Cancer 118:2665-2671. (Pubitemid 43673342)
11. Hoffmann D, Rivenson A, Abbi R, and Wynder EL (1993) A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone in F344 rats. Cancer Res 53:2758-2761. (Pubitemid 23180511)
12. Kieffer TJ, Heller RS, Unson CG, Weir GC, and Habener JF (1996) Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets. Endocrinology 137: 5119-5125. (Pubitemid 26403357)
13. Maisonneuve P, Frulloni L, Müllhaupt B, Faitini K, Cavallini G, Lowenfels AB, and Ammann RW (2006) Impact of smoking on patients with idiopathic chronic pancreatitis. Pancreas 33:163-168. (Pubitemid 44174564)
14. Meda P, Kohen E, Kohen C, Rabinovitch A, and Orci L (1982) Direct communication of homologous and heterologous endocrine islet cells in culture. J Cell Biol 92:221-226. (Pubitemid 12138129)
15. Milnerowicz H, Sliwinska-Mosson M, Rabczyński J, Nowak M, and Milnerowicz S (2007) Dysfunction of the pancreas in healthy smoking persons and patients with chronic pancreatitis. Pancreas 34:46-54. (Pubitemid 46045720)
16. Mohelnikova-Duchonova B, Vrana D, Holcatova I, Ryska M, Smerhovsky Z, and Soucek P (2010) CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. Pancreas 39:144-148.
17. Mulder I, Hoogenveen RT, van Genugten ML, Lankisch PG, Lowenfels AB, de Hollander AE, and Bueno-de-Mesquita HB (2002) Smoking cessation would substantially reduce the future incidence of pancreatic cancer in the European Union. Eur J Gastroenterol Hepatol 14:1343- 1353.
18. Nakajima M, Itoh M, Sakai H, Fukami T, Katoh M, Yamazaki H, Kadlubar FF, Imaoka S, Funae Y, and Yokoi T (2006) CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl. Int J Cancer 119:2520-2526. (Pubitemid 44691304)
19. Orci L, Malaisse-Lagae F, Ravazzola M, Rouiller D, Renold AE, Perrelet A, and Unger R (1975) A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas. J Clin Invest 56:1066-1070.
20. Prokopczyk B, Hoffmann D, Bologna M, Cunningham AJ, Trushin N, Akerkar S, Boyiri T, Amin S, Desai D, Colosimo S, et al. (2002) Identification of tobacco-derived compounds in human pancreatic juice. Chem Res Toxicol 15:677-685. (Pubitemid 34535123)
21. Skrodeniene E, Marciulionyte D, Padaiga Z, Jasinskiene E, Sadauskaite-Kuehne V, and Ludvigsson J (2008) Environmental risk factors in prediction of childhood prediabetes. Medicina 44:56-63.
22. Standop J, Schneider MB, Ulrich A, and Pour PM (2001) Experimental animal models in pancreatic carcinogenesis: lessons for human pancreatic cancer. Dig Dis 19:24-31. (Pubitemid 32506989)
23. Standop J, Schneider MB, Ulrich A, Chauhan S, Moniaux N, Büchler MW, Batra SK, and Pour PM (2002) The pattern of xenobiotic-metabolizing enzymes in the human pancreas. J Toxicol Environ Health A 65:1379-1400.
24. Standop J, Schneider M, Ulrich A, Büchler MW, and Pour PM (2003) Differences in immunohistochemical expression of xenobiotic-metabolizing enzymes between normal pancreas, chronic pancreatitis and pancreatic cancer. Toxicol Pathol 31:506-513. (Pubitemid 37151423)
25. Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, and Ding X (2000) Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res 60:5074-5079.
26. Tranah GJ, Holly EA, Wang F, and Bracci PM (2011) Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of pancreatic cancer: a population-based study in the San Francisco Bay Area. BMC Cancer 11:138.
27. Ulrich AB, Standop J, Schmied BM, Schneider MB, Lawson TA, and Pour PM (2002) Species differences in the distribution of drug-metabolizing enzymes in the pancreas. Toxicol Pathol 30:247-253. (Pubitemid 34293049)
28. Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ, and Teitelman G (2006) Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation. Endocrinology 147:3995-4006. (Pubitemid 44268351)
29. Wang MB, Bullock J, and Boyle JR (2001) Physiology, 4th ed. Lippincott, Philadelphia.
30. Wang SL, He XY, Shen J, Wang JS, and Hong JY (2006) The missense genetic polymorphisms of human CYP2A13: functional significance in carcinogen activation and identification of a null allelic variant. Toxicol Sci 94:38-45.
31. Wittel UA, Pandey KK, Andrianifahanana M, Johansson SL, Cullen DM, Akhter MP, Brand RE, Prokopczyk B, and Batra SK (2006) Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats. Am J Gastroenterol 101:148-159. (Pubitemid 43381723)
32. Zeldin DC, Foley J, Boyle JE, Moomaw CR, Tomer KB, Parker C, Steenbergen C, and Wu S (1997) Predominant expression of an arachidonate epoxygenase in islets of Langerhans cells in human and rat pancreas. Endocrinology 138:1338-1346. (Pubitemid 27089795)
33. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, and Hong JY (2006) CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody. Drug Metab Dispos 34:1672-1676. (Pubitemid 44427469)