Hepatitis B virus DNA splicing in Lebanese blood donors and genotype A to E Strains: Implications for hepatitis B virus DNA quantification and infectivity

Journal of Clinical Microbiology

Volumn 50, Issue 10, 2012, Pages 3159-3167

  El Chaar, Mira ^a,c   El Jisr, Tamima ^b   Allain, Jean Pierre ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MAKASSED GENERAL HOSPITAL   (Lebanon)

^c UNIVERSITY OF BALAMAND   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; VIRUS DNA;

ADULT; ARTICLE; BLOOD DONOR; BLOOD SAMPLING; COPY NUMBER VARIATION; DNA DETERMINATION; DNA EXTRACTION; DNA SPLICING; DNA STRUCTURE; ETHNIC GROUP; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS A VIRUS; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HEPATITIS DELTA VIRUS; HEPATITIS E VIRUS; HUMAN; HUMAN CELL; LEBANESE; LEBANON; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SEROCONVERSION; SPECIES DIFFERENTIATION; UNINDEXED SEQUENCE; VIRUS CARRIER; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN;

ADOLESCENT; ADULT; BLOOD DONORS; CLUSTER ANALYSIS; DNA, VIRAL; GENETIC VARIATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; LEBANON; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; RECOMBINATION, GENETIC; SEQUENCE ANALYSIS, DNA; VIRAL LOAD; YOUNG ADULT;

HEPATITIS B VIRUS;

EID: 84866466575     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01251-12     Document Type: Article

References (39)

1. Allain JP, et al. 2003. The risk of hepatitis B virus infection by transfusion in Kumasi, Ghana. Blood 101:2419-2425.
2. Allice T, et al. 2008. Comparison of the Cobas Ampliprep/Cobas TaqMan HBV Test versus the Cobas Amplicor HBV monitor for HBV-DNA detection and quantification during antiviral therapy. New Microbiol. 31:27-35. (Pubitemid 351422070)
3. Biswas R, et al. 2003. Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection. Transfusion 43:788-798. (Pubitemid 36629125)
4. Carman WF, et al. 1990. Vaccine-induced escape mutant of hepatitis B virus. Lancet 336:325-329. (Pubitemid 20264145)
5. Chen PJ, Chen CR, Sung JL, Chen DS. 1989. Identification of a doubly spliced viral transcript joining the separated domains for putative protease and reverse transcriptase of hepatitis B virus. J. Virol. 63:4165-4171.
6. Chudy M, Hanschmann K-M, Kreß J, Gerlich W, Nübling CM. 2009. Collaborative study to establish a World Health Organization international genotype panel for hepatitis B virus nucleic acid amplification technique (NAT)-based assays. http://whqlibdoc.who.int/hq/2009/WHO-BS-09.2121-eng.pdf.
7. Cox LE, Arslan O, Allain JP. 2011. Characterization of hepatitis B virus in Turkish blood donors, and the prevalence of the SP1 splice variant. J. Med. Virol. 83:1321-1325.
8. El Chaar M, Candotti D, Crowther RA, Allain JP. 2010. Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection. Hepatology 52:1600-1610.
9. El-Zaatari M, et al. 2007. Hepatitis B virus DNA in serum of 'anti-HBc only'-positive healthy Lebanese blood donors: significance and possible implications. J. Hosp. Infect. 66:278-282. (Pubitemid 46979841)
10. Funk ML, Rosenberg DM, Lok AS. 2002. World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants. J. Viral Hepat. 9:52-61. (Pubitemid 36002487)
11. Garbuglia AR, et al. 2007. Comparison of Versant HBV DNA and COBAS AmpliPrep-COBAS TaqMan assays for hepatitis B DNA quantitation: possible clinical implications. J. Virol. Methods 146:274-280. (Pubitemid 350030945)
12. Garmiri P, Rezvan H, Abolghasemi H, Allain JP. 2011. Full genome characterization of hepatitis B virus strains from blood donors in Iran. J. Med. Virol. 83:948-952.
13. Gunther S, Sommer G, Iwanska A, Will H. 1997. Heterogeneity and common features of defective hepatitis B virus genomes derived from spliced pregenomic RNA. Virology 238:363-371. (Pubitemid 28218154)
14. Hass M, et al. 2005. Functional analysis of hepatitis B virus reactivating in hepatitis B surface antigen-negative individuals. Hepatology 42:93-103. (Pubitemid 40911316)
15. Hsia CC, Purcell RH, Farshid M, Lachenbruch PA, Yu MY. 2006. Quantification of hepatitis B virus genomes and infectivity in human serum samples. Transfusion 46:1829-1835. (Pubitemid 44435737)
16. Jilbert AR, Miller DS, Scougall CA, Turnbull H, Burrell CJ. 1996. Kinetics of duck hepatitis B virus infection following low dose virus inoculation: one virus DNA genome is infectious in neonatal ducks. Virology 226:338-345. (Pubitemid 27025813)
17. Komiya Y, et al. 2008. Minimum infectious dose of hepatitis B virus in chimpanzees and difference in the dynamics of viremia between genotype A and genotype C. Transfusion 48:286-294.
18. Lee C, Kim J, Shin SG, Hwang S. 2006. Absolute and relative QPCR quantification of plasmid copy number in Escherichia coli. J. Biotechnol. 123:273-280. (Pubitemid 44294582)
19. Lin X, Wen Y, Wan D, Qian G, Gu J. 2002. Structural and functional analysis of 2.2 kb spliced variant of hepatitis B virus genomes isolated from liver tissues from hepatocellular carcinoma patients. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16:11-15. (In Chinese.)
20. Mahgoub S, Candotti D, El Ekiaby M, Allain JP. 2011. Hepatitis B virus (HBV) infection and recombination between HBV genotypes D and E in asymptomatic blood donors from Khartoum, Sudan. J. Clin. Microbiol. 49:298-306.
21. Meldal BH, Moula NM, Barnes IH, Boukef K, Allain JP. 2009. A novel hepatitis B virus subgenotype, D7, in Tunisian blood donors. J. Gen. Virol. 90:1622-1628.
22. Norder H, Courouce AM, Magnius LO. 1992. Molecular basis of hepatitis B virus serotype variations within the four major subtypes. J. Gen. Virol. 73(Part 12):3141-3145. (Pubitemid 23014164)
23. Okamoto H, et al. 1988. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J. Gen. Virol. 69(Part 10):2575-2583.
24. Pol J, et al. 2008. Prospective comparison of Abbott RealTime HBV DNA and Versant HBV DNA 3.0 assays for hepatitis B DNA quantitation: impact on HBV genotype monitoring. J. Virol. Methods 154:1-6.
25. Ronsin C, Pillet A, Bali C, Denoyel GA. 2006. Evaluation of the COBAS AmpliPrep-total nucleic acid isolation-COBAS TaqMan hepatitis B virus (HBV) quantitative test and comparison to the Versant HBV DNA 3.0 assay. J. Clin. Microbiol. 44:1390-1399.
26. Saab BR, Nassar NT, Musharrafieh U, Araj GF, Khogali M. 2007. Prevalence of hepatitis B in a presumably healthy Lebanese population. J. Med. Liban. 55:11-14. (Pubitemid 46724161)
27. Saldanha J, et al. 2001. An international collaborative study to establish a World Health Organization international standard for hepatitis B virus DNA nucleic acid amplification techniques. Vox Sang. 80:63-71. (Pubitemid 35333911)
28. Satake M, et al. 2007. Infectivity of blood components with low hepatitis B virus DNA levels identified in a lookback program. Transfusion 47:1197-1205. (Pubitemid 46934327)
29. Sharara AI, et al. 2004. Prevalence of restriction fragment length polymorphism patterns of hepatitis B virus compatible with genotype D in Lebanon. Eur. J. Clin. Microbiol. Infect. Dis. 23:861-863. (Pubitemid 40379008)
30. Soussan P, et al. 2008. Expression of defective hepatitis B virus particles derived from singly spliced RNA is related to liver disease. J. Infect. Dis. 198:218-225. (Pubitemid 352019287)
31. Soussan P, et al. 2003. The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis. J. Hepatol. 38:343-348. (Pubitemid 36286548)
32. Su TS, et al. 1989. Hepatitis B virus transcript produced by RNA splicing. J. Virol. 63:4011-4018.
33. Suzuki T, Masui N, Kajino K, Saito I, Miyamura T. 1989. Detection and mapping of spliced RNA from a human hepatoma cell line transfected with the hepatitis B virus genome. Proc. Natl. Acad. Sci. U. S. A. 86:8422-8426. (Pubitemid 19286070)
34. Tabuchi A, et al. 2008. Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes. J. Med. Virol. 80:2064-2068.
35. Thibault V, et al. 2009. Impact of hepatitis B virus genotypes and surface antigen variants on the performance of HBV real time PCR quantification. J. Virol. Methods 159:265-270.
36. Tian Y, et al. 2007. The amino acid residues at positions 120 to 123 are crucial for the antigenicity of hepatitis B surface antigen. J. Clin. Microbiol. 45:2971-2978. (Pubitemid 47417342)
37. Welzel TM, et al. 2006. Real-time PCR assay for detection and quantification of hepatitis B virus genotypes A to G. J. Clin. Microbiol. 44:3325-3333. (Pubitemid 44413772)
38. Yang JF, et al. 2009. Comparison of clinical application of the Abbott HBV PCR kit and the Versant HBV DNA 3.0 test to measure serum hepatitis B virus DNA in Taiwanese patients. Kaohsiung J. Med. Sci. 25:413-422.
39. Zahn A, et al. 2008. Molecular characterization of occult hepatitis B virus in genotype E-infected subjects. J. Gen. Virol. 89:409-418. (Pubitemid 351634258)