Heterogeneity and common features of defective hepatitis B virus genomes derived from spliced pregenomic RNA

Virology

Volumn 238, Issue 2, 1997, Pages 363-371

  Günther, Stephan ^a   Sommer, Gunhild ^a   Iwanska, Alicja ^a   Will, Hans ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HEPATITIS B VIRUS; LIFE CYCLE; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; VIRUS ENVELOPE; VIRUS GENE; VIRUS GENOME;

EID: 0031585536     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8863     Document Type: Article

References (34)

1. Chen P. J., Chen C. R., Sung J. L., Chen D. S. Identification of a doubly spliced viral transcript joining the separated domains for putative protease and reverse transcriptase of hepatitis B virus. J. Virol. 63:1989;4165-4171.
2. Choo K. B., Liew L. N., Chong K. Y., Lu R. H., Cheng W. T. Transgenome transcription and replication in the liver and extrahepatic tissues of a human hepatitis B virus transgenic mouse. Virology. 182:1991;785-792.
3. Emerman M., Vazeux R., Peden K. The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization. Cell. 57:1989;1155-1165.
4. Fouillot N., Tlouzeau S., Rossignol J.-M., Jean-Jean O. Translation of the hepatitis B virus P gene by ribosomal scanning as an alternative to internal initiation. J. Virol. 67:1993;4886-4895.
5. Galibert F., Mandart E., Fitoussi F., Tiollais P., Charnay P. Nucleotide sequence of the hepatitis B genome (subtype ayw) cloned inE. coli. Nature (London). 281:1979;646-650.
6. Ganem D. Hepadnaviridae and their replication. Fields Virology. 1996;Lippincott-Raven, Philadelphia. p. 2703-2737.
7. Günther S., Li B.-C., Miska S., Krüger D. H., Meisel H., Will H. A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients. J. Virol. 69:1995;5437-5444.
8. Hadzopoulou-Cladaras M., Felber B. K., Cladaras C., Athanassopoulos A., Tse A., Pavlakis G. N. The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J. Virol. 63:1989;1265-1274.
9. Hantz O., Baginski I., Fourel I., Chemin I., Trepo C. Viral spliced RNA are produced, encapsidated, and reverse transcribed duringin vivo. Virology. 190:1992;193-200.
10. Holland J. J. Defective viral genomes. Fields B. N., Knipe D. M. Virology. 1990;151-165 Raven Press, New York.
11. Huang J., Liang T. J. A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products. Mol. Cell. Biol. 13:1993;7476-7486.
12. Huang Z. M., Yen T. S. Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm. J. Virol. 68:1994;3193-3199.
13. Huang Z. M., Yen T. S. Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts. Mol. Cell. Biol. 15:1995;3864-3869.
14. Izaurralde E., Mattaj I. W. Transport of RNA between nucleus and cytoplasm. Semin. Cell. Biol. 3:1992;279-288.
15. Jackson I. J. A reappraisal of non-consensus mRNA splice sites. Nucleic Acids Res. 19:1991;3795-3798.
16. Kajino K., Ohta Y., Miyamura T., Saito I. Efficient cloning of hepatitis B virus DNA from single-stranded replicative intermediates and its application to S1 mapping of viral RNA in human liver tissue. J. Med. Virol. 33:1991;33-38.
17. Malim M. H., Hauber J., Le S. Y., Maizel J. V., Cullen B. R. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature. 338:1989;254-257.
18. Mount S. M. A catalogue of splice junction sequences. Nucleic Acids Res. 10:1982;459-472.
19. Obert S., Zachmann-Brand B., Deindl E., Tucker W., Bartenschlager R., Schaller H. A spliced hepadnavirus RNA that is essential for virus replication. EMBO J. 15:1996;2565-2574.
20. Ogston C. W., Razman D. G. Spliced RNA of woodchuck hepatitis virus. Virology. 189:1992;245-252.
21. Rosmorduc O., Petit M. A., Pol S., Capel F., Bortolotti F., Berthelot P., Brechot C., Kremsdorf D. In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA. Hepatology. 22:1995;10-19.
22. Scaglioni P., Melegari M., Takahashi M., Chowdhury J. R., Wands J. Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents. Hepatology. 24:1996;1010-1017.
23. Scaglioni P. P., Melegari M., Wands J. R. Characterization of hepatitis B virus core mutants that inhibit viral replication. Virology. 205:1994;112-120.
24. Smith C. W., Porro E. B., Patton J. G., Nadal-Ginard B. Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns. Nature. 342:1989;243-247.
25. Su T. S., Lai C. J., Huang J. L., Lin L. H., Yauk Y. K., Chang C. M., Lo S. J., Han S. H. Hepatitis B virus transcript produced by RNA splicing. J. Virol. 63:1989a;4011-4018.
26. Su T. S., Lui W. Y., Lin L. H., Han S. H., P'eng F. K. Analysis of hepatitis B virus transcripts in infected human livers. Hepatology. 9:1989b;180-185.
27. Suzuki T., Kajino K., Masui N., Saito I., Miyamura T. Alternative splicing of hepatitis B virus RNAs in HepG2 cells transfected with the viral DNA. Virology. 179:1990;881-885.
28. Suzuki T., Masui N., Kajino K., Saito I., Miyamura T. Detection and mapping of spliced RNA from a human hepatoma cell line transfected with the hepatitis B virus genome. Proc. Natl. Acad. Sci. USA. 86:1989;8422-8426.
29. Terre S., Petit M. A., Brechot C. Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo. J. Virol. 65:1991;5539-5543.
30. von Weizsäcker F., Wieland S., Blum H. E. Inhibition of viral replication by genetically engineered mutants of the duck hepatitis B virus core protein. Hepatology. 24:1996;294-299.
31. Wu H. L., Chen P. J., Tu S. J., Lin M. H., Lai M. Y., Chen D. S. Characterization and genetic analysis of alternatively spliced transcripts of hepatitis B virus in infected human liver tissues and transfected HepG2 cells. J. Virol. 65:1991;1680-1686.
32. Zeitlin S., Efstratiadis A. In vivo splicing products of the rabbit beta-globin pre-mRNA. Cell. 39:1984;589-602.
33. Zhang P., Raney A. K., McLachlan A. Characterization of the hepatitis B virus X- and nucleocapsid gene transcriptional regulatory elements. Virology. 191:1992;31-41.
34. Ziemer M., Garcia P., Shaul Y., Rutter W. J. Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line. J. Virol. 53:1985;885-892.