Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization

Journal of Biological Chemistry

Volumn 287, Issue 38, 2012, Pages 31813-31822

  Ha, Chang Man ^a   Park, Daehun ^a   Han, Jeong Kyu ^a   Jang, June Ill ^b   Park, Jae Yong ^c,d   Hwang, Eun Mi ^d   Seok, Heon ^e   Chang, Sunghoe ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Ulsan National Institute of Science and Technology   (South Korea)

^c Gyeongsang National University School of Medicine   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

^e Jungwon University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENTION DEFICIT HYPERACTIVITY DISORDER; BIPOLAR DISORDER; CELL SURFACES; DIRECT INTERACTIONS; NEUROPSYCHIATRIC DISORDER; PHORBOL 12 MYRISTATE 13 ACETATES; TERNARY COMPLEX; THERAPEUTIC TARGETS;

CELL MEMBRANES; DISEASES; NEUROPHYSIOLOGY; PHOSPHORYLATION; VOLATILE FATTY ACIDS;

AMINES;

6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; BRAIN PROTEIN; CALCYON; DOPAMINE 1 RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; DENDRITIC SPINE; HIPPOCAMPUS; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALS; BRAIN; ENDOCYTOSIS; GENE LIBRARY; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MODELS, NEUROLOGICAL; NEURONS; PHOSPHORYLATION; PROTEIN BINDING; RATS; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D1; SIGNAL TRANSDUCTION;

EID: 84866411770     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.370601     Document Type: Article

References (34)

1. 5 dopamine receptors stimulate intracellular calcium release in primary cultures of neocortical and hippocampal neurons. J. Neurophysiol. 87, 2167-2175
2. 1 dopamine receptor interacting protein. Science 287, 1660-1664
3. Lezcano, N., Mrzljak, L., Levenson, R., and Bergson, C. (2006) Retraction. Science 314, 1681
4. 1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. Arch. Gen. Psychiatry 60, 311-319
5. Clinton, S. M., Ibrahim, H. M., Frey, K. A., Davis, K. L., Haroutunian, V., and Meador-Woodruff, J. H. (2005) Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilin. Am. J. Psychiatry 162, 1859-1871 (Pubitemid 41428615)
6. Trantham-Davidson, H., Vazdarjanova, A., Dai, R., Terry, A., and Bergson, C. (2008) Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice. Behav. Brain Res. 189, 244-249
7. Vazdarjanova, A., Bunting, K., Muthusamy, N., and Bergson, C. (2011) Calcyon up-regulation in adolescence impairs response inhibition and working memory in adulthood. Mol. Psychiatry 16, 672-684
8. Heijtz, R. D., Alexeyenko, A., and Castellanos, F. X. (2007) Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD. Behav. Brain Funct. 3, 33
9. Luo, X., Kranzler, H., Lappalainen, J., Rosenheck, R., Charney, D., Zuo, L., Erdos, J., van Kammen, D. P., and Gelernter, J. (2004) CALCYON gene variation, schizophrenia, and cocaine dependence. Am. J. Med. Genet. B Neuropsychiatr. Genet. 125B, 25-30 (Pubitemid 38141398)
10. Lidow, M. S., Roberts, A., Zhang, L., Koh, P. O., Lezcano, N., and Bergson, C. (2001) Receptor cross-talk protein, calcyon, regulates affinity state of dopamine D1 receptors. Eur. J. Pharmacol. 427, 187-193 (Pubitemid 32913285)
11. Xiao, J., Dai, R., Negyessy, L., and Bergson, C. (2006) Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. J. Biol. Chem. 281, 15182-15193 (Pubitemid 43855108)
12. Cho, K. O., Hunt, C. A., and Kennedy, M. B. (1992) The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9, 929-942
13. 1 receptor signaling by PSD-95. J. Biol. Chem. 282, 15778-15789
14. s-protein activation. Cell Res. 19, 612-624
15. 1•PSD-95•NMDA receptor complex. J. Neurosci. 29, 2948-2960
16. Hallett, P. J., Collins, T. L., Standaert, D. G., and Dunah, A. W. (2008) Biochemical fractionation of brain tissue for studies of receptor distribution and trafficking. Curr. Protoc. Neurosci. Chapter 1, Unit 1 16
17. Chang, S., and De Camilli, P. (2001) Glutamate regulates actin-based motility in axonal filopodia. Nat. Neurosci. 4, 787-793 (Pubitemid 32702510)
18. Xia, Z., Dudek, H., Miranti, C. K., and Greenberg, M. E. (1996) Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J. Neurosci. 16, 5425-5436 (Pubitemid 26277871)
19. Kim, E., and Sheng, M. (2004) PDZ domain proteins of synapses. Nat. Rev. Neurosci. 5, 771-781 (Pubitemid 39336214)
20. Kennedy, M. B. (2000) Signal-processing machines at the postsynaptic density. Science 290, 750-754
21. Kerppola, T. K. (2006) Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells. Nat. Protoc. 1, 1278-1286
22. Morell, M., Espargaro, A., Aviles, F. X., and Ventura, S. (2008) Study and selection of in vivo protein interactions by coupling bimolecular fluorescence complementation and flow cytometry. Nat. Protoc. 3, 22-33
23. Shyu, Y. J., Liu, H., Deng, X., and Hu, C. D. (2006) Identification of new fluorescent protein fragments for bimolecular fluorescence complementation analysis under physiological conditions. BioTechniques 40, 61-66 (Pubitemid 46534939)
24. Greengard, P., Allen, P. B., and Nairn, A. C. (1999) Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 23, 435-447 (Pubitemid 29359916)
25. 1 receptors: implications for ADHD. Physiol. Behav. 92, 155-160
26. 2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS One 5, e11038
27. 1 receptors in working memory. Neural Netw. 15, 561-572
28. 1 dopamine receptors potentiate NMDA-mediated excitability increase in layer V prefrontal cortical pyramidal neurons. Cereb. Cortex 11, 452-462
29. Davidson, H. T., Xiao, J., Dai, R., and Bergson, C. (2009) Calcyon is necessary for activity-dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus. Eur. J. Neurosci. 29, 42-54
30. Feng, W., and Zhang, M. (2009) Organization and dynamics of PDZ domain-related supramodules in the postsynaptic density. Nat. Rev. Neurosci. 10, 87-99
31. Sornarajah, L., Vasuta, O. C., Zhang, L., Sutton, C., Li, B., El-Husseini, A., and Raymond, L. A. (2008) NMDA receptor desensitization regulated by direct binding to PDZ1-2 domains of PSD-95. J. Neurophysiol. 99, 3052-3062
32. Hu, S. Q., Zhu, J., Pei, D. S., Zong, Y. Y., Yan, J. Z., Hou, X. Y., and Zhang, G. Y. (2009) Overexpression of the PDZ1 domain of PSD-95 diminishes ischemic brain injury via inhibition of the GluR6•PSD-95•MLK3 pathway. J. Neurosci. Res. 87, 3626-3638
33. Pegan, S., Tan, J., Huang, A., Slesinger, P. A., Riek, R., and Choe, S. (2007) NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD-95. Biochemistry 46, 5315-5322 (Pubitemid 46717255)
34. Imamura, F., Maeda, S., Doi, T., and Fujiyoshi, Y. (2002) Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel. J. Biol. Chem. 277, 3640-3646 (Pubitemid 34953237)