Determination of appropriate stage of human-induced pluripotent stem cell-derived cardiomyocytes for drug screening and pharmacological evaluation in vitro

Journal of Biomolecular Screening

Volumn 17, Issue 9, 2012, Pages 1192-1203

  Shinozawa, Tadahiro ^a   Imahashi, Kenichi ^a   Sawada, Hiroshi ^a   Furukawa, Hatsue ^a   Takami, Kenji ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

cardiomyocyte; contractile function; gene expression; human induced pluripotent stem cells; sarcoplasmic reticulum

Indexed keywords

ACTIN; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN 2; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHOLAMBAN; RYANODINE RECEPTOR 2; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.5; TROPONIN T;

ACTIN FILAMENT; ARTICLE; CELL DIFFERENTIATION; CELL SHAPE; CONTROLLED STUDY; DRUG SCREENING; ELECTROPHYSIOLOGY; GENE EXPRESSION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN CELL; HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTE; IN VITRO STUDY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM;

ACTION POTENTIALS; CALCIUM CHANNEL BLOCKERS; CELL DIFFERENTIATION; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION PROFILING; HUMANS; INDUCED PLURIPOTENT STEM CELLS; ION CHANNELS; MICROELECTRODES; MICROSCOPY, ELECTRON, TRANSMISSION; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; MYOFIBRILS; SARCOPLASMIC RETICULUM; TIME FACTORS;

EID: 84866409388     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112449864     Document Type: Article

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