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Bioorganic and Medicinal Chemistry

Volumn 20, Issue 19, 2012, Pages 5763-5773

Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase

(2) Hawker, Dustin D a Silverman, Richard B a

a NORTHWESTERN UNIVERSITY (United States)

Author keywords

Aminobutyric acid; Enzyme inhibition; GABA aminotransferase; Heteroaromatic compounds; Synthetic substrates

Indexed keywords

4 (AMINOMETHYL) 1H PYRROLE 2 CARBOXYLIC ACID; 4 (AMINOMETHYL)FURAN 2 CARBOXYLIC ACID; 4 (AMINOMETHYL)FURAN 3 CARBOXYLIC ACID; 4 (AMINOMETHYL)THIOPHENE 2 CARBOXYLIC ACID; 4 (AMINOMETHYL)THIOPHENE 3 CARBOXYLIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRATE AMINOTRANSFERASE INHIBITOR; 4 AMINOBUTYRIC ACID; 5 (AMINOMETHYL) 1H PYRROLE 2 CARBOXYLIC ACID; 5 (AMINOMETHYL)FURAN 2 CARBOXYLIC ACID; 5 (AMINOMETHYL)THIOPHENE 2 CARBOXYLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE;

4-AMINOBUTYRATE TRANSAMINASE; ANIMALS; BRAIN; DRUG DESIGN; ENZYME INHIBITORS; EPILEPSY; GAMMA-AMINOBUTYRIC ACID; HUMANS; HYDROCARBONS, AROMATIC; SUBSTRATE SPECIFICITY; SWINE;

MAMMALIA;

EID: 84866404197 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.08.009 Document Type: Article

Times cited : (19)

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