A new class of conformationally rigid analogues of 4-amino-5- halopentanoic acids, potent inactivators of γ-aminobutyric acid aminotransferase

Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2000, Pages 706-720

  Qiu, Jian ^a   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 BROMO 4 FLUOROCYCLOPENTANE 1 CARBOXYLIC ACID; 3 AMINO 2,4 DIBROMOCYCLOPENTANE 1 CARBOXYLIC ACID; 3 AMINO 4 BROMO 2 FLUOROCYCLOPENTANE 1 CARBOXYLIC ACID; 3 AMINO 4 BROMOCYCLOPENTANE 1 CARBOXYLIC ACID; 3 AMINO 4 FLUOROCYCLOPENTANE 1 CARBOXYLIC ACID; 3ALPHA AMINO 2BETA BROMO 4BETA HYDROXYCYCLOPENTANE 1ALPHA CARBOXYLIC ACID; 3ALPHA AMINO 2BETA BROMOCYCLOPENTANE 1ALPHA CARBOXYLIC ACID; 3ALPHA AMINO 4BETA BROMO 2BETA HYDROXYCYCLOPENTANE 1ALPHA CARBOXYLIC ACID; 3BETA AMINO 4,4 DIFLUOROCYCLOPENTANE 1BETA CARBOXYLIC ACID; 4 AMINO 5 FLUOROVALERIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; VIGABATRIN;

ARTICLE; CHEMICAL BOND; DEGRADATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INACTIVATION; MOLECULAR STABILITY;

4-AMINOBUTYRATE TRANSAMINASE; ENZYME INHIBITORS; KINETICS; PENTANOIC ACIDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034001395     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9904755     Document Type: Article

References (35)

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