A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 19, 2012, Pages 5915-5927

  Ikeuchi, Hideyuki ^a   Ahn, Yong Mo ^b   Otokawa, Takuya ^a   Watanabe, Bunta ^a   Hegazy, Lamees ^b   Hiratake, Jun ^a   Richards, Nigel G J ^b  

^a KYOTO UNIVERSITY   (Japan)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Acute lymphoblastic leukemia; Asparagine synthetase; Cell death; l Asparagine amidohydrolase; MOLT 4 leukemia cell line; Structure activity relationship; Sulfoximine; Transition state analogue inhibitor

Indexed keywords

2 AMINOETHYL [METHYLSULFONIMIDOYL] N ADENYLATE; 2,2,2 TRICHLOROETHYL 2 [N [(ALLYLOXY)(2',3' O ISOPROPYLIDENEADENOSIN 5' YLOXY)PHOSPHORYL]METHYLSULFONIMIDOYL]ETHYLCARBAMATE; 2,2,2 TRICHLOROETHYL N 2 [METHYLSULFINYL]ETHYLCARBAMATE; 2,2,2 TRICHLOROETHYL N 2 [METHYLSULFONIMIDOYL]ETHYLCARBAMATE; 3 [N [(ADENOSIN 5' YLOXY)(HYDROXY)PHOSPHORYL]METHYLSULFONIMIDOYL]PROPANOIC ACID; ADENYLATED SULFOXIMINE; ALLYL 3 [METHYLSULFONIMIDOYL]PROPANOATE; ALLYL 3 [N [(ALLYLOXY)(2',3' O ISOPROPYLIDENEADENOSIN 5' YLOXY)PHOSPHORYL]METHYLSULFONIMIDOYL]PROPANOATE; ANTILEUKEMIC AGENT; ASPARAGINASE; ASPARTATE AMMONIA LIGASE; ASPARTATE AMMONIA LIGASE INHIBITOR; SULFOXIMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CANCER RESISTANCE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL PH; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; LEUKEMIA CELL;

AMIDOHYDROLASES; ANTINEOPLASTIC AGENTS; ASPARAGINASE; ASPARAGINE; ASPARTATE-AMMONIA LIGASE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; IMINES; MODELS, MOLECULAR; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SULFUR COMPOUNDS;

EID: 84866398938     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.047     Document Type: Article

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