The novel compound liguzinediol exerts positive inotropic effects in isolated rat heart via sarcoplasmic reticulum Ca2 + ATPase-dependent mechanism

Life Sciences

Volumn 91, Issue 11-12, 2012, Pages 402-408

  Chen, Long ^a,d   Xu, Yi ^a   Li, Wei ^a   Wu, Hao ^a   Luo, Zhuoka ^a   Li, Xuehua ^a   Huang, Feifei ^a   Young, Clint ^b   Liu, Zheng ^a   Zhou, Shuyuan ^c  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b Xenon Pharmaceuticals Inc   (Canada)

^c INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^d Institute of Chinese Medicine of Taizhou China Medical City   (China)

Author keywords

Calcium transient; L type calcium channel; Liguzinediol; Ryanodine receptor; SERCA2a

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CAFFEINE; CALCIUM CHANNEL L TYPE; CALCIUM ION; ISOBUTYLMETHYLXANTHINE; LIGUZINEDIOL; NATURAL PRODUCT; NIMODIPINE; OUABAIN; PRAZOSIN; PROPRANOLOL; RUTHENIUM RED; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; HEART FAILURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART RATE; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; PATCH CLAMP; RAT;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CAFFEINE; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NIMODIPINE; OUABAIN; PRAZOSIN; PROPRANOLOL; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RUTHENIUM RED; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; THAPSIGARGIN;

RATTUS; STROPHANTHUS GRATUS;

EID: 84866391992     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.08.001     Document Type: Article

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