Design, synthesis and evaluation of novel metalloproteinase inhibitors based on l-tyrosine scaffold

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 19, 2012, Pages 5738-5744

  Cheng, Xian Chao ^a   Wang, Run Ling ^a   Dong, Zhen Ke ^a   Li, Jing ^a   Li, Yao Yuan ^a   Li, Rong Rong ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

HDAC 8 inhibitors; IC 50; l tyrosine derivatives; MMP 2 inhibitors; Synthesis

Indexed keywords

3 [4 (BENZYLOXY)PHENYL] 2 (4 METHYLBENZENE 1 SULFONYL AMIDO)PROPANOIC ACID; 3 [4 (BENZYLOXY)PHENYL] 2 (ACETAMIDO)PROPANOIC ACID; 3 [4 (BENZYLOXY)PHENYL] 2 (BENZAMIDO)PROPANOIC ACID; 3 [4 (BENZYLOXY)PHENYL] 2 (METHANESULFONYL AMIDO)PROPANOIC ACID; 3 [4 (PHENYLETHYLOXY)PHENYL] 2 (ACETAMIDO)PROPANOIC ACID; 3 [4 (PHENYLETHYLOXY)PHENYL] 2 (BENZAMIDO)PROPANOIC ACID; 3 [4 (PHENYLETHYLOXY)PHENYL] 2 (METHANESULFONYL AMIDO)PROPANOIC ACID; GELATINASE A; HISTONE DEACETYLASE 8; MATRIX METALLOPROTEINASE INHIBITOR; METHYL 2 (4 METHYL)BENZAMIDO 3 [4 (BENZYLOXY)PHENYL]PROPANOATE; METHYL 2 (4 METHYLBENZAMIDO) 3 [4 (PHENYLETHYLOXY)PHENYL]PROPANOATE; METHYL 2 (4 METHYLBENZENE 1 SULFONYL AMIDO) 3 [4 (BENZYLOXY)PHENYL]PROPANOATE; METHYL 2 (4 METHYLBENZENE 1 SULFONYL AMIDO) 3 [4 (PHENYLETHYLOXY)PHENYL]PROPANOATE; METHYL 2 ACETAMIDO 3 [4 (BENZYLOXY)PHENYL]PROPANOATE; METHYL 2 ACETAMIDO 3 [4 (PHENYLETHYLOXY)PHENYL]PROPANOATE; METHYL 2 BENZAMIDO 3 [4 (BENZYLOXY)PHENYL]PROPANOATE; METHYL 2 BENZAMIDO 3 [4 (PHENYLETHYLOXY)PHENYL]PROPANOATE; METHYL 2 METHANESULFONYL AMIDO 3 [4 (BENZYLOXY)PHENYL]PROPANOATE; METHYL 2 METHANESULFONYL AMIDO 3 [4 (PHENYLETHYLOXY)PHENYL]PROPANOATE; N HYDROXY 3 (4 BENZYLOXYPHENYL) 2 (4 METHANEBENZENE 1 SULFONYL AMIDO)PROPANAMIDE; N HYDROXY 3 (4 BENZYLOXYPHENYL) 2 (4 METHYLBENZAMIDO)PROPANAMIDE; N HYDROXY 3 (4 BENZYLOXYPHENYL) 2 (ACETAMIDO)PROPANAMIDE; N HYDROXY 3 (4 BENZYLOXYPHENYL) 2 (BENZAMIDO)PROPANAMIDE; N HYDROXY 3 (4 BENZYLOXYPHENYL) 2 (METHANESULFONYL AMIDO)PROPANAMIDE; N HYDROXY 3 (4 PHENYLETHYLOXYPHENYL) 2 (4 METHYLBENZAMIDO)PROPANAMIDE; N HYDROXY 3 (4 PHENYLETHYLOXYPHENYL) 2 (BENZAMIDO)PROPANAMIDE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; HISTONE DEACETYLASES; HUMANS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE INHIBITORS; MODELS, MOLECULAR; REPRESSOR PROTEINS; TYROSINE;

EID: 84866390999     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.014     Document Type: Article

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