Diverse mechanisms of antidiabetic effects of the different procyanidin oligomer types of two different cinnamon species on db/db mice

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 36, 2012, Pages 9144-9150

  Chen, Liang ^a   Sun, Peng ^a,b   Wang, Ting ^b   Chen, Kaixian ^a,b   Jia, Qi ^a   Wang, Heyao ^b   Li, Yiming ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cinnamom; Cinnamomum cassia; Cinnamomum tamala; diabetes mellitus; procyanidin oligomers

Indexed keywords

CINNAMOM; CINNAMOMUM CASSIA; CINNAMOMUM TAMALA; DIABETES MELLITUS; PROCYANIDINS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAMMALS; TISSUE;

OLIGOMERS;

ANTIDIABETIC AGENT; BIFLAVONOID; CATECHIN; PLANT EXTRACT; PROANTHOCYANIDIN; PROCYANIDIN;

ANIMAL; CHEMISTRY; CINNAMOMUM ZEYLANICUM; COMPARATIVE STUDY; CONFERENCE PAPER; DISEASE MODEL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MALE; METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYTOTHERAPY;

ANIMALS; BIFLAVONOIDS; BLOOD GLUCOSE; CATECHIN; CINNAMOMUM ZEYLANICUM; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PROANTHOCYANIDINS;

CINNAMOMUM AROMATICUM; CINNAMOMUM TAMALA; CINNAMOMUM VERUM; MUS;

EID: 84866390416     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf3024535     Document Type: Conference Paper

References (35)

1. Li, W. L.; Zheng, H. C.; Bukuru, J.; De Kimpe, N. Natural medicines used in the traditional Chinese medical system for therapy of diabetesmellitus J. Ethnopharmacol. 2004, 92, 1-21
2. Patel, D. K.; Prasad, S. K.; Kumar, R.; Hemalatha, S. An overview on antidiabetic medicinal plants having insulin mimetic property Asian Pac. J. Trop. Biomed. 2012, 320-330
3. Jung, M.; Park, M.; Lee, H. C.; Kang, Y. H.; Kang, E. S.; Kim, S. K. Antidiabetic agents from medicinal plants Curr. Med. Chem. 2006, 13, 1203-1218
4. Verspohl, E. J.; Bauer, K.; Neddermann, E. Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro Phytother. Res. 2005, 19, 203-206
5. Khan, A.; Safdar, M.; Mohammad, M. A.; Khan, N. K.; Anderson, R. A. Cinnamon improves glucose and lipids of people with type 2 diabetes Diabetes Care 2003, 26, 3215-3218
6. Akilen, R.; Tsiami, A.; Devendra, D.; Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic type 2 diabetic patients in the UK: A randomized, placebo-controlled, double-blind clinical trial Diabetic Med. 2010, 27, 1159-1167
7. Khan, A.; Bryden, N. A.; Polansky, M. M.; Anderson, R. A. Insulin potentiating factor and chromium content of selected foods and spices Biol. Trace Elem. Res. 1990, 24, 183-188
8. Jarvill-Taylor, K. J.; Anderson, R. A.; Graves, D. J. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes J. Am. Coll. Nutr. 2001, 20, 327-336
9. Imparl-Radosevich, J.; Deas, S.; Polansky, M. M.; Baedke, D. A.; Ingebritsen, T. S.; Anderson, R. A.; Graves, D. J. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: Implications for cinnamon regulation of insulin signalling Horm. Res. 1998, 50, 177-182
10. Qin, B.; Nagasaki, M.; Ren, M.; Bajotto, G.; Oshida, Y.; Sato, Y. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats Diabetes Res. Clin. Pract. 2003, 62, 139-148
11. Qin, B.; Nagasaki, M.; Ren, M.; Bajotto, G.; Oshida, Y.; Sato, Y. Cinnamon extract prevents the insulin resistance induced by a high-fructose diet Horm. Metab. Res. 2004, 36, 119-125
12. Lee, J. S.; Jeon, S. M.; Park, E. M.; Huh, T. L.; Kwon, O. S; Lee, M. K.; Choi, M. S. Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats J. Med. Food 2003, 6, 183-191
13. Anderson, R. A. Chromium and polyphenols from cinnamon improve insulin sensitivity Proc. Nutr. Soc. 2008, 67, 48-53
14. Peng, X.; Cheng, K. W.; Ma, J.; Chen, B.; Ho, C. T.; Lo, C.; Chen, F.; Wang, M. Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts J. Agric. Food Chem. 2008, 56, 1907-1911
15. Peng, X.; Ma, J.; Chao, J.; Sun, Z.; Chang, R. C.; Tse, I.; Li, E. T.; Chen, F.; Wang, M. Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption J. Agric. Food Chem. 2010, 58, 6692-6696
16. Rafehi, H.; Ververis, K.; Karagiannis, T. C. Controversies surrounding the clinical potential of cinnamon for the management of diabetes Diabetes, Obes. Metab. 2012, 14, 493-499
17. 1c, and serum lipids in diabetes mellitus type 2 Eur. J. Clin. Invest. 2006, 36, 340-344
18. Crawford, P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: A randomized, controlled trial J. Am. Board Fam. Med. 2009, 22, 507-512
19. Blevins, S. M.; Leyva, M. J.; Brown, J.; Wright, J.; Scofield, R. H.; Aston, C. E. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes Diabetes Care 2007, 30, 2236-2237
20. Vanschoonbeek, K.; Thomassen, B. J.; Senden, J. M.; Wodzig, W. K.; vanLoon, L. J. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients J. Nutr. 2006, 136, 977-980
21. Anderson, R. A.; Broadhurst, C. L.; Polansky, M. M.; Schmidt, W. F.; Khan, A.; Flanagan, V. P.; Schoene, N. W.; Graves, D. J. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity J. Agric. Food Chem. 2004, 52, 65-70
22. Porter, L. J. Flavans and proanthocyanidins. In The Flavonoids; Harbone, J. B., Ed.; Chapman and Hall, Ltd.: New York, 1988; pp 21-63.
23. Lu, Z.; Jia, Q.; Wang, R.; Wu, X.; Wu, Y.; Huang, C.; Li, Y. Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different cinnamon barks Phytomedicine 2011, 18, 298-302
24. Tang, J. S.; Hou, Y. L.; Gao, H.; Chen, X.; Sun, S. C.; Guo, T. Z.; Kobayashi, H.; Ye, W. C.; Yao, X. S. Polyphenols from Parabarium huaitingii and their positive inotropic and anti-myocardial infarction effects in rats Phytomedicine 2011, 18, 544-550
25. Talpur, N.; Echard, B.; Ingram, C.; Bagchi, D.; Preuss, H. Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: A pilot study Diabetes, Obes. Metab. 2005, 7, 193-199
26. Roffey, B.; Atwal, A.; Kubow, S. Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells Mol. Nutr. Food Res. 2006, 50, 739-745
27. Gupta, R.; Agnnihotri, P. K.; Johri, S.; Saxena, A. M. Hypoglycaemic activity of ethanol extract of Cinnamomum tamala leaves in normal and streptozotocin diabetic rats Iran. J. Pharm. Ther. 2009, 8, 17-21
28. Chakraborty, U.; Das, H. Antidiabetic and antioxidant activities of Cinnamomum tamala leaf extracts in STZ-treated diabetic rats Global J. Biotechnol. Biochem. 2010, 5, 12-18
29. Kim, S. H.; Hyun, S. H.; Choung, S. Y. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice J. Ethnopharmacol. 2006, 104, 119-123
30. Jia, Q.; Liu, X.; Wu, X.; Wang, R.; Hu, X.; Li, Y.; Huang, C. Hypoglycemic activity of a polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetic rats Phytomedicine 2009, 16, 744-750
31. Chandola, H. M.; Tripathi, S. N.; Udupa, K. N. Effect of Cinnamomum tamala on plasma insulin vis-à-vis blood sugar in patients of diabetes mellitus J. Res. Ayurveda Siddha 1980, 1, 345-357
32. Sheng, X.; Zhang, Y.; Gong, Z.; Huang, C.; Zang, Y. Q. Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors PPAR Res. 2008, 2008, 581348
33. Desvergne, B.; Wahli, W. Peroxisome proliferator-activated receptors: Nuclear control of metabolism Endocr. Rev. 1999, 20, 649-688
34. Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 2001, 357, 905-910.
35. Olefsky, J. M. Treatment of insulin resistance with peroxisome proliferator-activated receptor γ agonists J. Clin. Invest. 2000, 106, 467-472