Quantitative structure-activity relationship study and directed synthesis of Thieno[2,3-d]pyrimidine-2,4-diones as monocarboxylate transporter 1 inhibitors

Medicinal Chemistry Research

Volumn 21, Issue 9, 2012, Pages 2263-2272

  Devinyak, O T ^a,b   Slivka, Mikh V ^a   Slivka, Mar V ^a   Vais, V M ^a   Lendel, V G ^a  

^a UZHGOROD NATIONAL UNIVERSITY   (Ukraine)

^b Transcarpathian State University   (Ukraine)

Author keywords

Directed synthesis; In silico screening; Monocarboxylate transporter 1 inhibitor; N vinyl derivatives; QSAR; Thieno 2,3 d pyrimidine 2,4 dione

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOMODULATING AGENT; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 1 INHIBITOR; THIENO[2,3 D]PYRIMIDINE 2,4 DIONE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENERGY; IMMUNE RESPONSE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SOLVATION; THEORETICAL MODEL;

EID: 84866378060     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9748-4     Document Type: Article

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