Pathology of plaque haemorrhage and neovascularization of coronary artery

Journal of Cardiovascular Medicine

Volumn 13, Issue 10, 2012, Pages 620-627

  Kodama, Takahide ^a   Narula, Nupoor ^a   Agozzino, Manuela ^a   Arbustini, Eloisa ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Histopathology; intraplaque haemorrhage; neovascularization; plaque rupture; vulnerable plaque

Indexed keywords

HEMOSIDERIN;

ANGIOGENESIS; ANTICOAGULATION; ARTERY INTIMA PROLIFERATION; ATHEROSCLEROTIC PLAQUE; BLEEDING; CELL INFILTRATION; ENDOTHELIUM CELL; ERYTHROCYTE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INTRAPLAQUE HAEMORRHAGE; NEOVASCULARIZATION (PATHOLOGY); OPTICAL COHERENCE TOMOGRAPHY; PATHOPHYSIOLOGY; PLAQUE NEOVASCULARIZATION; REVIEW;

ACUTE CORONARY SYNDROME; ANIMALS; CORONARY ARTERY DISEASE; CORONARY VESSELS; DISEASE PROGRESSION; HEMORRHAGE; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PLAQUE, ATHEROSCLEROTIC; RISK FACTORS; RUPTURE, SPONTANEOUS;

EID: 84866375211     PISSN: 15582027     EISSN: 15582035     Source Type: Journal    
DOI: 10.2459/JCM.0b013e328356a5f2     Document Type: Review

References (58)

1. Ambrose JA, Tannenbaum MA, Alexopoulos D, et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 1988; 12:56-62.
2. Little WC, Constantinescu M, Applegate RJ, et al. Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 1988; 78:1157-1166.
3. Schaar JA, Muller JE, Falk E, et al. Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece. Eur Heart J 2004; 25:1077-1082.
4. Giroud D, Li JM, Urban P, Meier B, Rutishauser W. Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography. Am J Cardiol 1992; 69:729-732.
5. Andersson LC, von Willebrand E, Jokinen M, Karhi KK, Gahmberg CG. Glycophorin A as an erythroid marker in normal and malignant hematopoiesis. Haematol Blood Transfus 1981; 26:338-344.
6. Arbustini E, Morbini P, D'Armini AM, et al. Plaque composition in plexogenic and thromboembolic pulmonary hypertension: the critical role of thrombotic material in pultaceous core formation. Heart 2002; 88:177-182.
7. Kolodgie FD, Gold HK, Burke AP, et al. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 2003; 349:2316-2325.
8. Takaya N, Yuan C, Chu B, et al. Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study. Circulation 2005; 111:2768-2775.
9. Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003; 19:71-82.
10. An G, Wang H, Tang R, et al. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 2008; 117:3227-3237.
11. Burke AP, Farb A, Malcom GT, Liang Y, Smialek JE, Virmani R. Plaque rupture and sudden death related to exertion in men with coronary artery disease. JAMA 1999; 281:921-926.
12. McCarthy MJ, Loftus IM, Thompson MM, et al. Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology. J Vasc Surg 1999; 30:261-268.
13. Jeziorska M, Woolley DE. Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries. J Pathol 1999; 188:189-196.
14. Mofidi R, Crotty TB, McCarthy P, Sheehan SJ, Mehigan D, Keaveny TV. Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease. Br J Surg 2001; 88:945-950.
15. Kockx MM, Cromheeke KM, Knaapen MW, et al. Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis. Arterioscler Thromb Vasc Biol 2003; 23:440-446.
16. Fleiner M, Kummer M, Mirlacher M, et al. Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis. Circulation 2004; 110:2843-2850.
17. Vancov V. Structural basis of the microcirculation in the wall of arterial vessels. Bibl Anat 1973; 11:383-388.
18. Semenza GL. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol 2000; 59:47-53.
19. Gorlach A, Diebold I, Schini-Kerth VB, et al. Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22 (phox)-containing NADPH oxidase. Circ Res 2001; 89:47-54.
20. North S, Moenner M, Bikfalvi A. Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors. Cancer Lett 2005; 218:1-14.
21. Mallat Z, Besnard S, Duriez M, et al. Protective role of interleukin-10 in atherosclerosis. Circ Res 1999; 85:e17-e224.
22. Vanden Heuvel MM, Tensen CP, Van As JH, et al. Regulation of CD163 on macrophages: cross linking of CD163 induces signaling and activation. J Leuk Biol 1999; 66:858-866.
23. Philippidis P, Mason JC, Evans BJ, et al. Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res 2004; 94:119-126.
24. Moreno PR, Sanz J, Fuster V. Promoting mechanisms of vascular health: circulating progenitor cells, angiogenesis, and reverse cholesterol transport. J Am Coll Cardiol 2009; 53:2315-2323.
25. Zhang Y, Cliff WJ, Schoefl GI, Higgins G. Immunohistochemical study of intimal microvessels in coronary atherosclerosis. Am J Pathol 1993; 143:164-172.
26. Dunmore BJ, McCarthy MJ, Naylor AR, Brindle NP. Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques. J Vasc Surg 2007; 45:155-159.
27. Virmani R, Narula J, Farb A. When neoangiogenesis ricochets. Am Heart J 1998; 136:937-939.
28. Sluimer JC, Kolodgie FD, Bijnens AP, et al. Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage. J Am Coll Cardiol 2009; 53:1517-1527.
29. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000; 20:1262-1275.
30. Kim DN, Schmee J, Lee KT, Thomas WA. Atherosclerotic lesions in the coronary arteries of hyperlipidemic swine, part 1: cell increases, divisions, losses and cells of origin in first 90 days on diet. Atherosclerosis 1987; 64:231-242.
31. Schwartz SM, deBlois D, O'Brien ER. The intima: soil for atherosclerosis and restenosis. Circ Res 1995; 77:445-465.
32. McCaffrey TA, Du B, Consigli S, et al. Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells. J Clin Invest 1997; 100:2182-2188.
33. Tabas I, Li Y, Brocia RW, Xu SW, Swenson TL, Williams KJ. Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix: a possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. J Biol Chem 1993; 268:20419-20432.
34. Gössl M, Versari D, Hildebrandt HA. Segmental heterogeneity of vasa vasorum neovascularization in human coronary atherosclerosis. JACC Cardiovasc Imaging 2010; 3:32-40.
35. Boyle JJ, Harrington HA, Piper E, et al. Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. Am J Pathol 2009; 174:1097-1108.
36. Finn AV, Nakano M, Polavarapu R, et al. Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques. J Am Coll Cardiol 2012; 59:166-177.
37. Narula J, Finn AV, Demaria AN. Picking plaques that pop. J Am Coll Cardiol 2005; 45:1970-1973.
38. Yeagle PL. Cholesterol and the cell membrane. Biochim Biophys Acta 1985; 822:267-287.
39. Tangirala RK, Jerome WG, Jones NL, et al. Formation of cholesterol monohydrate crystals in macrophage-derived foam cells. J Lipid Res 1994; 35:93-104.
40. Tulenko TN, Chen M, Mason PE, Mason RP. Physical effects of cholesterol on arterial smooth muscle membranes: evidence of immiscible cholesterol domains and alterations in bilayer width during atherogenesis. J Lipid Res 1998; 39:947-956.
41. Heo SH, Cho CH, Kim HO, et al. Plaque ruptureis a determinantofvascular events in carotid artery atherosclerotic disease: involvement of matrix metalloproteinases 2 and 9. J Clin Neurol 2011; 7:69-76.
42. Miller YI, Shaklai N. Oxidative crosslinking of LDL protein induced by hemin: involvement of tyrosines. Biochem Mol Biol Int 1994; 34:1121-1129.
43. Balla G, Jacob HS, Eaton JW, Belcher JD, Vercellotti GM. Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury. Arterioscler Thromb 1991; 11:1700-1711.
44. Oliver MF, Davies MJ. The atheromatous lipid core. Eur Heart J 1998; 19:16-18.
45. Schick BP, Schick PK. Cholesterol exchange in platelets, erythrocytes and megakaryocytes. Biochim Biophys Acta 1985; 833: 281-290.
46. Derksen WJ, Peeters W, Tersteeg C, et al. Age and coumarin-type anticoagulation are associated with the occurrence of intraplaque hemorrhage, while statins are associated less with intraplaque hemorrhage: a large histopathological study in carotid and femoral plaques. Atherosclerosis 2011; 214:139-143.
47. Arbustini E, Gambarin FI. Theranostic strategy against plaque angiogenesis. JACC Cardiovasc Imaging 2008; 1:635-637.
48. Liu S, Widom J, Kemp CW, Crews CM, Clardy J. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science 1998; 282:1324-1327.
49. Takada Y, Ye X, Simon S. The integrins. Genome Biol 2007; 8:215.1-215.9.
50. Liu S. Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging. Mol Pharmacol 2006; 3:472-487.
51. McQuade P, Knight LC. Radiopharmaceuticals for targeting the angiogenesis marker alpha(v)beta(3). Q J Nucl Med 2003; 47:209-220.
52. Winter PM, Neubauer AM, Caruthers SD, et al. Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler Thromb Vasc Biol 2006; 26:2103-2109.
53. Winter PM, Caruthers SD, Zhang H, Williams TA, Wickline SA, Lanza GM. Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis. J Am Coll Cardiol Imag 2008; 1:624-634.
54. Moulton KS, Vakili K, Zurakowski D, et al. Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci U S A 2003; 100:4736-4741.
55. Gössl M, Herrmann J, Tang H, et al. Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia. Basic Res Cardiol 2009; 104:695-706.
56. Jang IK, Tearney GJ, MacNeill B, et al. In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation 2005; 111:1551-1555.
57. Nasu K, Tsuchikane E, Katoh O, et al. Accuracy of in vivo coronary plaque morphology assessment: a validation study of in vivo virtual histology compared with in vitro histopathology. J Am Coll Cardiol 2006; 47:2405-2412.
58. Hishikawa T, Ihara K, Ishibashi-Ueda H, NagatsukaK, Yamada M, Miyamoto S. Virtual histology-intravascular ultrasound in assessment of carotid plaques: ex vivo study. Neurosurgery 2009; 65:146-152.