Age and coumarin-type anticoagulation are associated with the occurrence of intraplaque hemorrhage, while statins are associated less with intraplaque hemorrhage: A large histopathological study in carotid and femoral plaques

Atherosclerosis

Volumn 214, Issue 1, 2011, Pages 139-143

  Derksen, Wouter J M ^a   Peeters, Wouter ^a,b   Tersteeg, Claudia ^a   de Vries, Jean Paul P M ^c   de Kleijn, Dominique P V ^a,b   Moll, Frans L ^a   van der Wal, Allard C ^d   Pasterkamp, Gerard ^a   Vink, Aryan ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c ST ANTONIUS HOSPITAL   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Anticoagulation; Atherosclerosis; Carotid plaque; Intraplaque hemorrhage; Statins

Indexed keywords

ACENOCOUMAROL; ACETYLSALICYLIC ACID; CLOPIDOGREL; COUMARIN; DIPYRIDAMOLE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PHENPROCOUMON;

ADULT; AGED; AGING; ANTICOAGULATION; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLEEDING; CAROTID ENDARTERECTOMY; CAROTID PLAQUE; DISEASE MARKER; ENDARTERECTOMY; FEMALE; FEMORAL PLAQUE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRAPLAQUE HEMORRHAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

AGE FACTORS; AGED; ANTICOAGULANTS; CAROTID ARTERIES; COUMARINS; ENDARTERECTOMY; ENDARTERECTOMY, CAROTID; FEMALE; FEMORAL ARTERY; HEMORRHAGE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PLAQUE, ATHEROSCLEROTIC; TREATMENT OUTCOME;

EID: 78650814970     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.10.022     Document Type: Article

References (30)

1. Lusby R.J., Ferrell L.D., Ehrenfeld W.K., Stoney R.J., Wylie E.J. Carotid plaque hemorrhage: its role in production of cerebral ischemia. Arch Surg 1982, 117:1479-1488.
2. Paterson J.C. Capillary rupture with intimal hemorrhage as a causative factor in coronary thrombosis. Arch Pathol 1938, 25:474-478.
3. Virmani R., Kolodgie F.D., Burke A.P., Farb A., Schwartz S.M. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000, 20:1262-1275.
4. Kolodgie F.D., Gold H.K., Burke A.P., et al. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 2003, 349:2316-2325.
5. Kockx M.M., Cromheeke K.M., Knaapen M.W., et al. Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis. Arterioscler Thromb Vasc Biol 2003, 23:440-446.
6. Hellings W.E., Peeters W., Moll F.L., et al. Composition of the carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study. Circulation 2010, 121:1941-1950.
7. Verhoeven B.A., Velema E., Schoneveld A.H., et al. Athero-express: differential atherosclerotic plaque expression of mrna and protein in relation to cardiovascular events and patient characteristics rationale and design. Eur J Epidemiol 2004, 19:1127-1133.
8. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American symptomatic carotid endarterectomy trial collaborators. N Engl J Med 1991, 325:445-453.
9. Endarterectomy for asymptomatic carotid artery stenosis. Executive committee for the asymptomatic carotid atherosclerosis study. Jama 1995, 273:1421-1428.
10. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the mrc European carotid surgery trial (ECST). Lancet 1998, 351:1379-1387.
11. Norgren L., Hiatt W.R., Dormandy J.A., Nehler M.R., Harris K.A., Fowkes F.G. Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg 2007, 45(Suppl S):S5-67.
12. Lennihan L., Kupsky W.J., Mohr J.P., Hauser W.A., Correll J.W., Quest D.O. Lack of association between carotid plaque hematoma and ischemic cerebral symptoms. Stroke 1987, 18:879-881.
13. Hellings W.E., Pasterkamp G., Vollebregt A., et al. Intraobserver and interobserver variability and spatial differences in histologic examination of carotid endarterectomy specimens. J Vasc Surg 2007, 46:1147-1154.
14. Gao P., Chen Z.Q., Bao Y.H., Jiao L.Q., Ling F. Correlation between carotid intraplaque hemorrhage and clinical symptoms: systematic review of observational studies. Stroke 2007, 38:2382-2390.
15. Stork J.L., Kimura K., Levi C.R., Chambers B.R., Abbott A.L., Donnan G.A. Source of microembolic signals in patients with high-grade carotid stenosis. Stroke 2002, 33:2014-2018.
16. Turu M.M., Krupinski J., Catena E., et al. Intraplaque mmp-8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound. Atherosclerosis 2006, 187:161-169.
17. Spagnoli L.G., Orlandi A., Mauriello A., et al. Aging and atherosclerosis in the rabbit 1. Distribution, prevalence and morphology of atherosclerotic lesions. Atherosclerosis 1991, 89:11-24.
18. van Oostrom O., Velema E., Schoneveld A.H., et al. Age-related changes in plaque composition: a study in patients suffering from carotid artery stenosis. Cardiovasc Pathol 2005, 14:126-134.
19. Pucci A., Sheiban I., Formato L., et al. In vivo coronary plaque histology in patients with stable and acute coronary syndromes: relationships with hyperlipidemic status and statin treatment. Atherosclerosis 2007, 194:189-195.
20. Bea F., Blessing E., Bennett B., Levitz M., Wallace E.P., Rosenfeld M.E. Simvastatin promotes atherosclerotic plaque stability in apoe-deficient mice independently of lipid lowering. Arterioscler Thromb Vasc Biol 2002, 22:1832-1837.
21. Insull W. The pathology of atherosclerosis: plaque development and plaque responses to medical treatment. Am J Med 2009, 122:S3-S14.
22. Libby P., Aikawa M. Mechanisms of plaque stabilization with statins. Am J Cardiol 2003, 91:4B-8B.
23. Verhoeven B.A., Moll F.L., Koekkoek J.A., et al. Statin treatment is not associated with consistent alterations in inflammatory status of carotid atherosclerotic plaques: a retrospective study in 378 patients undergoing carotid endarterectomy. Stroke 2006, 37:2054-2060.
24. Oake N., Jennings A., Forster A.J., Fergusson D., Doucette S., van Walraven C. Anticoagulation intensity and outcomes among patients prescribed oral anticoagulant therapy: a systematic review and meta-analysis. CMAJ 2008, 179:235-244.
25. Fuchs U. Submicroscopic changes of the rat lung following the administration of a coumarin derivative. Frankf Z Pathol 1965, 74:555-564.
26. Pratesi F., Spinelli P., Caramelli L., Tesi M., Dabizzi R.P. Ultrastructure of the cerebral capillaries in experimental ischemia and pharmacological action on it. Bibl Anat 1996, 10:174-183.
27. Kahn R.A., Johnson S.A., DeGraff A.F. Effects of sodium warfarin on capillary ultrastructure. Am J Pathol 1971, 65:149-156.
28. Leithäuser B., Mrowietz C., Hiebl B., Pindur G., Jung F. Capillary bleeding under oral anticoagulation. Clin Hemorheol Microcirc 2009, 43:167-171.
29. Paciaroni M., Bogousslavsky J. Primary secondary prevention of ischemic stroke. Eur Neurol 2010, 63:267-278.
30. Chu B., Kampschulte A., Ferguson M.S., et al. Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study. Stroke 2004, 35:1079-1084.