Stem Cell Selection In Vivo Using Foamy Vectors Cures Canine Pyruvate Kinase Deficiency

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Trobridge, Grant D ^a,b   Beard, Brian C ^a,b   Wu, Robert A ^a   Ironside, Christina ^a   Malik, Punam ^c   Kiem, Hans Peter ^a,b,d  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; CARMUSTINE; ENHANCED GREEN FLUORESCENT PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PYRUVATE KINASE; SPUMA VIRUS VECTOR; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL EXPANSION; CELL SELECTION; CISTRON; CONTROLLED STUDY; DOG; DRUG DOSE ESCALATION; ERYTHROCYTE DISORDER; EX VIVO STUDY; GENE THERAPY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PYRUVATE KINASE DEFICIENCY; STEM CELL GENE THERAPY;

ACUTE DISEASE; ANEMIA, HEMOLYTIC, CONGENITAL NONSPHEROCYTIC; ANIMALS; DISEASE MODELS, ANIMAL; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; DOGS; GENETIC THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MUTATION; PYRUVATE KINASE; PYRUVATE METABOLISM, INBORN ERRORS; SPUMAVIRUS; STEM CELLS; TRANSDUCTION, GENETIC; TRANSGENES; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEINS;

CANIS FAMILIARIS; HUMAN SPUMARETROVIRUS;

EID: 84866374267     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045173     Document Type: Article

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