A rapid and quantitative assay for measuring neighboring gene activation by vector proviruses

Molecular Therapy

Volumn 16, Issue 3, 2008, Pages 534-540

  Hendrie, Paul C ^a   Huo, Yunwen ^a   Stolitenko, Raisa B ^a   Russell, David W ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; LUCIFERASE; PHOSPHOGLYCERATE KINASE; RETROVIRUS VECTOR; VIRUS VECTOR;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INSERTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; LONG TERMINAL REPEAT; MURINE LEUKEMIA VIRUS; NONHUMAN; NORTHERN BLOTTING; PLASMID; PROMOTER REGION; PROVIRUS; QUANTITATIVE ANALYSIS; REPORTER GENE; SPUMA VIRUS; VIRUS TRANSCRIPTION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN SPUMARETROVIRUS; MURINAE; MURINE LEUKEMIA VIRUS;

EID: 39849099656     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/sj.mt.6300398     Document Type: Article

References (36)

1. MG Ott M Schmidt K Schwarzwaelder S Stein U Siler U Koehl Correction of X‐linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1‐EVI1, PRDM16 or SETBP1 Nat Med 12 2006 401 419
2. S Hacein‐Bey‐Abina C Von Kalle M Schmidt MP McCormack N Wulffraat P Leboulch LMO2‐associated clonal T cell proliferation in two patients after gene therapy for SCID‐X1 Science 302 2003 415 419
3. R Seggewiss S Pittaluga RL Adler FJ Guenaga C Ferguson IH Pilz Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque Blood 107 2006 3865 3867
4. E Montini D Cesana M Schmidt F Sanvito M Ponzoni C Bartholomae Hematopoietic stem cell gene transfer in a tumor‐prone mouse model uncovers low genotoxicity of lentiviral vector integration Nat Biotechnol 24 2006 687 696
5. Y Shou Z Ma T Lu BP Sorrentino Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy Proc Natl Acad Sci USA 103 2006 11730 11735
6. M Themis SN Waddington M Schmidt C von Kalle Y Wang F Al‐Allaf Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice Mol Ther 12 2005 763 771
7. Y Du NA Jenkins NG Copeland Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells Blood 106 2005 3932 3939
8. U Modlich J Bohne M Schmidt C von Kalle S Knöss A Schambach Cell culture assays reveal the importance of retroviral vector design for insertional genotoxicity Blood 108 2006 2545 2553
9. J Jonkers A Berns Retroviral insertional mutagenesis as a strategy to identify cancer genes Biochim Biophys Acta 1287 1996 29 57
10. Z Li J Düllmann B Schiedlmeier M Schmidt C von Kalle J Meyer Murine leukemia induced by retroviral gene marking Science 296 2002 497
11. M Gossen S Freundlieb G Bender G Müller W Hillen H Bujard Transcriptional activation by tetracyclines in mammalian cells Science 268 1995 1766 1769
12. M Gossen H Bujard Tight control of gene expression in mammalian cells by tetracycline‐responsive promoters Proc Natl Acad Sci USA 89 1992 5547 5551
13. SK Jang HG Kräusslich MJ Nicklin GM Duke AC Palmenberg E Wimmer A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation J Virol 62 1988 2636 2643
14. N Levitt D Briggs A Gil NJ Proudfoot Definition of an efficient synthetic poly(A) site Genes Dev 3 1989 1019 1025
15. MW McBurney LC Sutherland CN Adra B Leclair MA Rudnicki K Jardine The mouse Pgk‐1 gene promoter contains an upstream activator sequence Nucleic Acids Res 19 1991 5755 5761
16. FL Graham J Smiley WC Russell R Nairn Characteristics of a human cell line transformed by DNA from human adenovirus type 5 J Gen Virol 36 1977 59 74
17. GD Trobridge DG Miller MA Jacobs JM Allen HP Kiem R Kaul Foamy virus vector integration sites in normal human cells Proc Natl Acad Sci USA 103 2006 1498 1503
18. X Wu Y Li B Crise SM Burgess Transcription start regions in the human genome are favored targets for MLV integration Science 300 2003 1749 1751
19. S Laufs G Guenechea A Gonzalez‐Murillo K Zsuzsanna Nagy M Luz Lozano C del Val Lentiviral vector integration sites in human NOD/SCID repopulating cells J Gene Med 8 2006 1197 1207
20. S Laufs KZ Nagy FA Giordano A Hotz‐Wagenblatt WJ Zeller S Fruehauf Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns Mol Ther 10 2004 874 881
21. S Cereghini M Yaniv Assembly of transfected DNA into chromatin: structural changes in the origin‐promoter‐enhancer region upon replication EMBO J 3 1984 1243 1253
22. R Reeves CM Gorman B Howard Minichromosome assembly of non‐integrated plasmid DNA transfected into mammalian cells Nucleic Acids Res 13 1985 3599 3615
23. SW Jeong A Stein DNA sequence affects nucleosome ordering on replicating plasmids in transfected COS‐1 cells and in vitro J Biol Chem 269 1994 2197 2205
24. A Krumm L Madisen XJ Yang R Goodman Y Nakatani M Groudine Long‐distance transcriptional enhancement by the histone acetyltransferase PCAF Proc Natl Acad Sci USA 95 1998 13501 13506
25. F Recillas‐Targa AC Bell G Felsenfeld Positional enhancer‐blocking activity of the chicken beta‐globin insulator in transiently transfected cells Proc Natl Acad Sci USA 96 1999 14354 14359
26. AK Zaiss S Son LJ Chang RNA 3′ readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy J Virol 76 2002 7209 7219
27. RV Guntaka Transcription termination and polyadenylation in retroviruses Microbiol Rev 57 1993 511 521
28. N Inoue DW Russell Packaging cells based on inducible gene amplification for the production of adeno‐associated virus vectors J Virol 72 1998 7024 7031
29. MA Stockschlaeder R Storb WR Osborne AD Miller L‐histidinol provides effective selection of retrovirus‐vector‐transduced keratinocytes without impairing their proliferative potential Hum Gene Ther 2 1991 33 39
30. SC Barry B Harder M Brzezinski LY Flint J Seppen WR Osborne Lentivirus vectors encoding both central polypurine tract and posttranscriptional regulatory element provide enhanced transduction and transgene expression Hum Gene Ther 12 2001 1103 1108
31. R Zufferey T Dull RJ Mandel A Bukovsky D Quiroz L Naldini Self‐inactivating lentivirus vector for safe and efficient in vivo gene delivery J Virol 72 1998 9873 9880
32. HP Kiem J Allen G Trobridge E Olson K Keyser LJ Peterson Foamy virus‐mediated gene transfer to canine repopulating cells Blood 109 2006 65 70
33. M Cavazzana‐Calvo S Hacein‐Bey G de Saint Basile F Gross E Yvon P Nusbaum Gene therapy of human severe combined immunodeficiency (SCID)‐X1 disease Science 288 2000 669 672
34. G Trobridge N Josephson G Vassilopoulos J Mac DW Russell Improved foamy virus vectors with minimal viral sequences Mol Ther 6 2002 321 328
35. CB Lozzio BB Lozzio Human chronic myelogenous leukemia cell‐line with positive Philadelphia chromosome Blood 45 1975 321 334
36. J Sambrook DW Russell Molecular Cloning: A Laboratory Manual 3rd edn 2001 Cold Spring Harbor Laboratory Press Cold Spring Harbor 999