Nonlinear optical imaging for sensitive detection of crystals in bulk amorphous powders

Journal of Pharmaceutical Sciences

Volumn 101, Issue 11, 2012, Pages 4201-4213

  Kestur, Umesh S ^a,c   Wanapun, Duangporn ^b   Toth, Scott J ^b   Wegiel, Lindsay A ^a   Simpson, Garth J ^b   Taylor, Lynne S ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

Amorphous; Crystallinity; Powder X ray diffractometry; Raman spectroscopy; Second harmonic generation; Second order nonlinear imaging of chiral crystals; Solid dispersion

Indexed keywords

HYDROXYLPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; NAPROXEN; POLYMER; SOLVENT; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; CHIRALITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; OPTICAL IMAGING; OPTICS; PHYSICAL CHEMISTRY; RAMAN SPECTROMETRY; SECOND ORDER NONLINEAR IMAGING OF CHIRAL CRYSTAL; VALIDATION STUDY; X RAY DIFFRACTION;

EID: 84866357245     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23280     Document Type: Article

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