Pleuromutilin derivatives having a purine ring. Part 3: Synthesis and antibacterial activity of novel compounds possessing a piperazine ring spacer

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 1, 2009, Pages 175-179

  Hirokawa, Yoshimi ^a   Kinoshita, Hironori ^a   Tanaka, Tomoyuki ^a   Nakamura, Takanori ^a   Fujimoto, Koichi ^a   Kashimoto, Shigeki ^a   Kojima, Tsuyoshi ^a   Kato, Shiro ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Gram positive bacteria; MIC; MRSA; Piperazine ring; Pleuromutilin; PRSP; Purine ring; Spacer; VRE

Indexed keywords

PIPERAZINE DERIVATIVE; PLEUROMUTILIN; PLEUROMUTILIN DERIVATIVE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; DITERPENES; DRUG RESISTANCE; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; PURINES; SOLUBILITY; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 57749092778     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.127     Document Type: Article

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