Pleuromutilin derivatives having a purine ring. Part 1: New compounds with promising antibacterial activity against resistant Gram-positive pathogens

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3556-3561

  Hirokawa, Yoshimi ^a   Kinoshita, Hironori ^a   Tanaka, Tomoyuki ^a   Nakamura, Takanori ^a   Fujimoto, Koichi ^a   Kashimoto, Shigeki ^a   Kojima, Tsuyoshi ^a   Kato, Shiro ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Gram positive bacteria; Metabolic stability; MIC; MRSA; Pleuromutilin; PRSP; Purine ring; Sulfide; VRE

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; AZAMULIN; BACTERIAL PROTEIN; ESTER DERIVATIVE; GLYCOLIC ACID; MORPHOLINE; PIPERAZINE; PIPERIDINE; PLEUROMUTILIN; PROLINE DERIVATIVE; PURINE DERIVATIVE; RETAPAMULIN; TIAMULIN; VALUNEMULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG STRUCTURE; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN INTERACTION; PROTEIN SYNTHESIS;

ANTI-BACTERIAL AGENTS; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, BACTERIAL; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PURINES; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA;

EID: 44649173661     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.011     Document Type: Article

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