Selective and potent urea inhibitors of cryptosporidium parvum inosine 5′-monophosphate dehydrogenase

Journal of Medicinal Chemistry

Volumn 55, Issue 17, 2012, Pages 7759-7771

  Gorla, Suresh Kumar ^a   Kavitha, Mandapati ^a   Zhang, Minjia ^a   Liu, Xiaoping ^b   Sharling, Lisa ^b   Gollapalli, Deviprasad R ^a   Striepen, Boris ^b   Hedstrom, Lizbeth ^a   Cuny, Gregory D ^c,d  

^a BRANDEIS UNIVERSITY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 CHLOROPHENYL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 (3 CHLOROPHENYL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 (3,4 CHLOROPHENYL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 (4 BROMOPHENYL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 (4 CHLORO 3 NITROPHENYL) 3 [2 [3 [1 (HYDROXYIMINO]ETHYL]PHENYL]PROPAN 2 YL]UREA; 1 (4 CHLOROPHENYL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 (4 METHOXYPHENYL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 (NAPHTHALEN 1 YL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 (NAPHTHALEN 2 YL) 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 [2 (3 ACETYLPHENYL)PROPAN 2 YL] 3 (4 CHLOROPHENYL)UREA; 1 [2 (3 ACETYLPHENYL)PROPAN 2 YL] 3 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL] 3 (QUINOLIN 2 YL)UREA; 1 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL] 3 (QUINOLIN 3 YL)UREA; 1 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL] 3 (QUINOLIN 6 YL)UREA; 1 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL] 3 (QUINOLIN 7 YL)UREA; 1 [2 [3 [1 (HYDROXYIMINO)ETHYL]PHENYL]PROPAN 2 YL] 3 (NAPHTHALENE 2 YL)UREA; 1 [2 [3 [1 (HYDROXYIMINO)ETHYL]PHENYL]PROPAN 2 YL] 3 (QUINOLIN 7 YL)UREA; 1 [4 (TERT BUTYL)PHENYL] 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [2 [3 [1 (HYDROXYIMINO)ETHYL]PHENYL]PROPAN 2YL] UREA; 1 PHENYL 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 1(4 CHLOROPHENYL) 1 METHYL 3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREA; 2 CHLORO 5 [3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREIDO]BENZAMIE; 2 CHLORO N METHYL 5 [3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREIDO]BENZAMIE; 2 CHLORO N,N DIMETHYL 5 [3 [2 [3 (PROP 1 EN 2 YL)PHENYL]PROPAN 2 YL]UREIDO]BENZAMIE; ANTIPARASITIC AGENT; INOSINATE DEHYDROGENASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CRYPTOSPORIDIUM PARVUM; DRUG POTENCY; DRUG SYNTHESIS; FIBROBLAST; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TOXOPLASMA GONDII;

CRYPTOSPORIDIUM PARVUM; ENZYME INHIBITORS; HUMANS; IMP DEHYDROGENASE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84866324636     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3007917     Document Type: Article

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