The structural basis of Cryptosporidium-specific IMP dehydrogenase inhibitor selectivity

Journal of the American Chemical Society

Volumn 132, Issue 4, 2010, Pages 1230-1231

  MacPherson, Iain S ^a   Kirubakaran, Sivapriya ^a   Gorla, Suresh Kumar ^a   Riera, Thomas V ^a   D'Aquino, J Alejandro ^a   Zhang, Minjia ^a   Cuny, Gregory D ^b   Hedstrom, Lizbeth ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOWARFARES; CRYPTOSPORIDIUM; CRYPTOSPORIDIUM PARVUM; GUANINE NUCLEOTIDES; INHIBITOR SELECTIVITY; INOSINE; MONOPHOSPHATES; NANOMOLAR INHIBITORS; PARASITE-; STRUCTURAL BASIS;

DRUG THERAPY; ENZYMES;

ENZYME INHIBITION;

INOSINATE DEHYDROGENASE INHIBITOR; ANTIPROTOZOAL AGENT; ENZYME INHIBITOR; INOSINATE DEHYDROGENASE;

ARTICLE; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HYDROGEN BOND; NONHUMAN; STEREOSPECIFICITY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CRYPTOSPORIDIUM PARVUM; ENZYMOLOGY; HUMAN; METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTIPROTOZOAL AGENTS; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; IMP DEHYDROGENASE; MODELS, MOLECULAR;

EID: 77950442655     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja909947a     Document Type: Article

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