메뉴 건너뛰기




Volumn 7, Issue 9, 2012, Pages

Susceptibility towards Enterotoxigenic Escherichia coli F4ac Diarrhea Is Governed by the MUC13 Gene in Pigs

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN;

EID: 84866324489     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044573     Document Type: Article
Times cited : (54)

References (47)
  • 1
    • 0000242978 scopus 로고    scopus 로고
    • Prevalences of some virulence genes among Escherichia coli isolates from swine presented to a diagnostic laboratory in Iowa
    • Moon HW, Hoffman LJ, Cornick NA, Booher SL, Bosworth BT, (1999) Prevalences of some virulence genes among Escherichia coli isolates from swine presented to a diagnostic laboratory in Iowa. J Vet Diagn Invest 11: 557-560.
    • (1999) J Vet Diagn Invest , vol.11 , pp. 557-560
    • Moon, H.W.1    Hoffman, L.J.2    Cornick, N.A.3    Booher, S.L.4    Bosworth, B.T.5
  • 2
    • 0018386708 scopus 로고
    • Behavior of Escherichia coli antigens K88ab, K88ac, and K88ad in immunoelectrophoresis, double diffusion, and hemagglutination
    • Guinée PAM, Jansen WH, (1979) Behavior of Escherichia coli antigens K88ab, K88ac, and K88ad in immunoelectrophoresis, double diffusion, and hemagglutination. Infect Immun 23: 700-705.
    • (1979) Infect Immun , vol.23 , pp. 700-705
    • Guinée, P.A.M.1    Jansen, W.H.2
  • 3
    • 0002260011 scopus 로고
    • Inheritance of resistance to neonatal E. coli diarrhoea in the pig: examination of the genetic system
    • Gibbons RA, Sellwood R, Burrows M, Hunter PA, (1977) Inheritance of resistance to neonatal E. coli diarrhoea in the pig: examination of the genetic system. Theor Appl Genet 51: 65-70.
    • (1977) Theor Appl Genet , vol.51 , pp. 65-70
    • Gibbons, R.A.1    Sellwood, R.2    Burrows, M.3    Hunter, P.A.4
  • 4
    • 0036918601 scopus 로고    scopus 로고
    • Fine-mapping of the intestinal receptor locus for enterotoxigenic Escherichia coli F4ac on porcine chromosome 13
    • Python P, Jörg H, Neuenschwander S, Hagger C, Stricker C, et al. (2002) Fine-mapping of the intestinal receptor locus for enterotoxigenic Escherichia coli F4ac on porcine chromosome 13. Anim Genet 33: 441-447.
    • (2002) Anim Genet , vol.33 , pp. 441-447
    • Python, P.1    Jörg, H.2    Neuenschwander, S.3    Hagger, C.4    Stricker, C.5
  • 5
    • 1442348234 scopus 로고    scopus 로고
    • Linkage and comparative mapping of the locus controlling susceptibility towards E. coli F4ab/ac diarrhoea in pigs
    • Jørgensen CB, Cirera S, Anderson SI, Archibald AL, Raudsepp T, et al. (2003) Linkage and comparative mapping of the locus controlling susceptibility towards E. coli F4ab/ac diarrhoea in pigs. Cytogenet Genome Res 102: 157-162.
    • (2003) Cytogenet Genome Res , vol.102 , pp. 157-162
    • Jørgensen, C.B.1    Cirera, S.2    Anderson, S.I.3    Archibald, A.L.4    Raudsepp, T.5
  • 6
    • 69949143928 scopus 로고    scopus 로고
    • Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13
    • Joller D, Jørgensen CB, Bertschinger HU, Python P, Edfors I, et al. (2009) Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13. Anim Genet 40: 749-752.
    • (2009) Anim Genet , vol.40 , pp. 749-752
    • Joller, D.1    Jørgensen, C.B.2    Bertschinger, H.U.3    Python, P.4    Edfors, I.5
  • 7
    • 73849147953 scopus 로고    scopus 로고
    • Refined candidate region specified by haplotype sharing for Escherichia coli F4ab/F4ac susceptibility alleles in pigs
    • Jacobsen M, Kracht SS, Esteso G, Cirera S, Edfors I, et al. (2010) Refined candidate region specified by haplotype sharing for Escherichia coli F4ab/F4ac susceptibility alleles in pigs. Anim Genet 41: 21-25.
    • (2010) Anim Genet , vol.41 , pp. 21-25
    • Jacobsen, M.1    Kracht, S.S.2    Esteso, G.3    Cirera, S.4    Edfors, I.5
  • 8
    • 79951553660 scopus 로고    scopus 로고
    • The receptor locus for Escherichia coli F4ab/F4ac in the pig maps distal to the MUC4-LMLN region
    • Rampoldi A, Jacobsen MJ, Bertschinger HU, Joller D, Bürgi E, et al. (2011) The receptor locus for Escherichia coli F4ab/F4ac in the pig maps distal to the MUC4-LMLN region. Mamm Genome 22: 122-129.
    • (2011) Mamm Genome , vol.22 , pp. 122-129
    • Rampoldi, A.1    Jacobsen, M.J.2    Bertschinger, H.U.3    Joller, D.4    Bürgi, E.5
  • 9
    • 34547112519 scopus 로고    scopus 로고
    • The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infections in pigs
    • Peng QL, Ren J, Yan XM, Huang X, Tang H, et al. (2007) The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infections in pigs. Anim Genet 38: 397-400.
    • (2007) Anim Genet , vol.38 , pp. 397-400
    • Peng, Q.L.1    Ren, J.2    Yan, X.M.3    Huang, X.4    Tang, H.5
  • 10
    • 44049106830 scopus 로고    scopus 로고
    • Investigation of the porcine MUC13 gene: isolation, expression, polymorphisms and strong association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac
    • Zhang B, Ren J, Yan X, Huang X, Ji H, et al. (2008) Investigation of the porcine MUC13 gene: isolation, expression, polymorphisms and strong association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac. Anim Genet 39: 258-266.
    • (2008) Anim Genet , vol.39 , pp. 258-266
    • Zhang, B.1    Ren, J.2    Yan, X.3    Huang, X.4    Ji, H.5
  • 11
    • 79951581873 scopus 로고    scopus 로고
    • The porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac
    • Ji H, Ren J, Yan X, Huang X, Zhang B, et al. (2011) The porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac. Mol Bio Rep 38: 1593-1601.
    • (2011) Mol Bio Rep , vol.38 , pp. 1593-1601
    • Ji, H.1    Ren, J.2    Yan, X.3    Huang, X.4    Zhang, B.5
  • 12
    • 34547227250 scopus 로고    scopus 로고
    • Characterization of polymorphisms of transferrin receptor and their association with susceptibility to ETEC F4ab/ac in pigs
    • Wang Y, Ren J, Lan L, Yan X, Huang X, et al. (2007) Characterization of polymorphisms of transferrin receptor and their association with susceptibility to ETEC F4ab/ac in pigs. J Anim Breed Genet 124: 225-229.
    • (2007) J Anim Breed Genet , vol.124 , pp. 225-229
    • Wang, Y.1    Ren, J.2    Lan, L.3    Yan, X.4    Huang, X.5
  • 13
    • 16844367114 scopus 로고    scopus 로고
    • Inheritance of the F4ab, F4ac and F4ad E. coli receptors in swine and examination of four candidate genes for F4acR
    • Python P, Jörg H, Neuenschwander S, Asai-Coakwell M, Hagger C, et al. (2005) Inheritance of the F4ab, F4ac and F4ad E. coli receptors in swine and examination of four candidate genes for F4acR. J Anim Breed Genet 122 (s1): 5-14.
    • (2005) J Anim Breed Genet , vol.122 , Issue.s1 , pp. 5-14
    • Python, P.1    Jörg, H.2    Neuenschwander, S.3    Asai-Coakwell, M.4    Hagger, C.5
  • 15
    • 79959675298 scopus 로고    scopus 로고
    • Characterisation of five candidate genes within the ETEC F4ab/ac candidate region in pigs
    • Jacobsen M, Cirera S, Joller D, Esteso G, Kracht SS, et al. (2011) Characterisation of five candidate genes within the ETEC F4ab/ac candidate region in pigs. BMC Res Notes 4: 225.
    • (2011) BMC Res Notes , vol.4 , pp. 225
    • Jacobsen, M.1    Cirera, S.2    Joller, D.3    Esteso, G.4    Kracht, S.S.5
  • 16
    • 58549095934 scopus 로고    scopus 로고
    • A linkage map of the porcine genome from a large-scale White Duroc × Erhualian resource population and evaluation of factors affecting recombination rates
    • Guo Y, Mao H, Ren J, Yan X, Duan Y, et al. (2009) A linkage map of the porcine genome from a large-scale White Duroc × Erhualian resource population and evaluation of factors affecting recombination rates. Anim Genet 40: 47-52.
    • (2009) Anim Genet , vol.40 , pp. 47-52
    • Guo, Y.1    Mao, H.2    Ren, J.3    Yan, X.4    Duan, Y.5
  • 17
    • 67650744884 scopus 로고    scopus 로고
    • Distribution of Escherichia coli F4 adhesion phenotypes in pigs of 15 Chinese and Western breeds and a White Duroc × Erhualian intercross
    • Yan X, Huang X, Ren J, Zou Z, Yang S, et al. (2009) Distribution of Escherichia coli F4 adhesion phenotypes in pigs of 15 Chinese and Western breeds and a White Duroc × Erhualian intercross. J Med Microbiol 58: 1112-1117.
    • (2009) J Med Microbiol , vol.58 , pp. 1112-1117
    • Yan, X.1    Huang, X.2    Ren, J.3    Zou, Z.4    Yang, S.5
  • 18
    • 68349137618 scopus 로고    scopus 로고
    • Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology
    • Ramos AM, Crooijmans RPMA, Affara NA, Amaral AJ, Archibald AL, et al. (2009) Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology. PLoS One 4: e6524.
    • (2009) PLoS One , vol.4
    • Ramos, A.M.1    Crooijmans, R.P.M.A.2    Affara, N.A.3    Amaral, A.J.4    Archibald, A.L.5
  • 19
    • 0028138998 scopus 로고
    • Characterization of porcine intestinal receptors for the K88ac fimbrial adhesion of Escherichia coli as mucin-type sialoglycoproteins
    • Erickson AK, Baker DR, Bosworth BT, Casey TA, Benfield DA, et al. (1994) Characterization of porcine intestinal receptors for the K88ac fimbrial adhesion of Escherichia coli as mucin-type sialoglycoproteins. Infect Immun 62: 5404-5410.
    • (1994) Infect Immun , vol.62 , pp. 5404-5410
    • Erickson, A.K.1    Baker, D.R.2    Bosworth, B.T.3    Casey, T.A.4    Benfield, D.A.5
  • 20
    • 0031715108 scopus 로고    scopus 로고
    • Expression of mucin-type glycoprotein K88 receptors strongly correlates with piglet susceptibilty to K88+ enterotoxigenic Escherichia coli, but adhesion of this bacterium to brush borders does not
    • Francis DH, Grange PA, Zeman DH, Baker DR, Sun RG, et al. (1998) Expression of mucin-type glycoprotein K88 receptors strongly correlates with piglet susceptibilty to K88+ enterotoxigenic Escherichia coli, but adhesion of this bacterium to brush borders does not. Infect Immun 66: 4050-4055.
    • (1998) Infect Immun , vol.66 , pp. 4050-4055
    • Francis, D.H.1    Grange, P.A.2    Zeman, D.H.3    Baker, D.R.4    Sun, R.G.5
  • 21
    • 0032039010 scopus 로고    scopus 로고
    • Characterization of the carbohydrate moiety of intestinal mucin-type sialoglycoprotein receptors for the K88ac fimbrial adhesion of Escherichia coli
    • Grange PA, Erickson AK, Anderson TJ, Francis DH, (1998) Characterization of the carbohydrate moiety of intestinal mucin-type sialoglycoprotein receptors for the K88ac fimbrial adhesion of Escherichia coli. Infect Immun 66: 1613-1621.
    • (1998) Infect Immun , vol.66 , pp. 1613-1621
    • Grange, P.A.1    Erickson, A.K.2    Anderson, T.J.3    Francis, D.H.4
  • 22
    • 0037479789 scopus 로고    scopus 로고
    • Mucin and Toll-like receptors in host defense against intestinal parasites
    • Moncada DM, Kammanadiminti SJ, Chadee K, (2003) Mucin and Toll-like receptors in host defense against intestinal parasites. Trends Parasitol 19: 305-311.
    • (2003) Trends Parasitol , vol.19 , pp. 305-311
    • Moncada, D.M.1    Kammanadiminti, S.J.2    Chadee, K.3
  • 24
    • 80655124696 scopus 로고    scopus 로고
    • The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
    • Sheng YH, Lourie R, Lindén SK, Jeffery PL, Roche D, et al. (2011) The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut 60: 1661-1670.
    • (2011) Gut , vol.60 , pp. 1661-1670
    • Sheng, Y.H.1    Lourie, R.2    Lindén, S.K.3    Jeffery, P.L.4    Roche, D.5
  • 25
    • 79956000989 scopus 로고    scopus 로고
    • Mucin 13: structure, function, and potential roles in cancer pathogenesis
    • Maher DM, Gupta BK, Nagata S, Jaggi M, Chauhan SC, et al. (2011) Mucin 13: structure, function, and potential roles in cancer pathogenesis. Mol Cancer Res 9: 531-537.
    • (2011) Mol Cancer Res , vol.9 , pp. 531-537
    • Maher, D.M.1    Gupta, B.K.2    Nagata, S.3    Jaggi, M.4    Chauhan, S.C.5
  • 26
    • 84863345495 scopus 로고    scopus 로고
    • A genome-wide association study identifies two novel promising candidate genes affecting Escherichia coli F4ab/F4ac susceptibility in swine
    • Fu WX, Liu Y, Lu X, Niu XY, Ding XD, et al. (2012) A genome-wide association study identifies two novel promising candidate genes affecting Escherichia coli F4ab/F4ac susceptibility in swine. PLoS One 7: e32127.
    • (2012) PLoS One , vol.7
    • Fu, W.X.1    Liu, Y.2    Lu, X.3    Niu, X.Y.4    Ding, X.D.5
  • 27
    • 79952355186 scopus 로고    scopus 로고
    • Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profile
    • Hoorens PR, Rinaldi M, Li RW, Goddeeris B, Claerebout E, (2011) Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profile. BMC Genomics 12: 140.
    • (2011) BMC Genomics , vol.12 , pp. 140
    • Hoorens, P.R.1    Rinaldi, M.2    Li, R.W.3    Goddeeris, B.4    Claerebout, E.5
  • 28
    • 84859782551 scopus 로고    scopus 로고
    • Susceptibility of piglets to enterotoxigenic Escherichia coli is not related to the expression of MUC13 and MUC20
    • Schroyen M, Stinckens A, Verhelst R, Geens M, Cox E, et al. (2012) Susceptibility of piglets to enterotoxigenic Escherichia coli is not related to the expression of MUC13 and MUC20. Anim Genet 43: 324-327.
    • (2012) Anim Genet , vol.43 , pp. 324-327
    • Schroyen, M.1    Stinckens, A.2    Verhelst, R.3    Geens, M.4    Cox, E.5
  • 29
    • 43549093774 scopus 로고    scopus 로고
    • Structure and function of the polymeric mucins in airways mucus
    • Thornton DJ, Rousseau K, McGuckin MA, (2008) Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 70: 459-486.
    • (2008) Annu Rev Physiol , vol.70 , pp. 459-486
    • Thornton, D.J.1    Rousseau, K.2    McGuckin, M.A.3
  • 30
    • 0031081320 scopus 로고    scopus 로고
    • Distribution of K88 Escherichia coli-adhesive and nonadhesive phenotypes among pigs of four breeds
    • Baker DR, Billey LO, Francis DH, (1997) Distribution of K88 Escherichia coli-adhesive and nonadhesive phenotypes among pigs of four breeds. Vet Microbiol 54: 123-132.
    • (1997) Vet Microbiol , vol.54 , pp. 123-132
    • Baker, D.R.1    Billey, L.O.2    Francis, D.H.3
  • 32
    • 0029945706 scopus 로고    scopus 로고
    • Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker sharing statistics
    • Sobel E, Lange K, (1996) Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker sharing statistics. Am J Hum Genet 58: 1323-1337.
    • (1996) Am J Hum Genet , vol.58 , pp. 1323-1337
    • Sobel, E.1    Lange, K.2
  • 33
    • 0035741831 scopus 로고    scopus 로고
    • Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees
    • Sobel E, Sengul H, Weeks DE, (2001) Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees. Hum Heredity 52: 121-131.
    • (2001) Hum Heredity , vol.52 , pp. 121-131
    • Sobel, E.1    Sengul, H.2    Weeks, D.E.3
  • 35
    • 35048838105 scopus 로고    scopus 로고
    • Genomewide rapid association using mixed model and regression: a fast and simple method for genome-wide pedigree-based quantitative trait loci association analysis
    • Aulchenko YS, de Koning DJ, Haley C, (2007) Genomewide rapid association using mixed model and regression: a fast and simple method for genome-wide pedigree-based quantitative trait loci association analysis. Genetics 177: 577-585.
    • (2007) Genetics , vol.177 , pp. 577-585
    • Aulchenko, Y.S.1    de Koning, D.J.2    Haley, C.3
  • 36
    • 44249112333 scopus 로고    scopus 로고
    • A genomic background based method for association analysis in related individuals
    • Amin N, van Duijn CM, Aulchenko YS, (2007) A genomic background based method for association analysis in related individuals. PLoS One 2: e1274.
    • (2007) PLoS One , vol.2
    • Amin, N.1    van Duijn, C.M.2    Aulchenko, Y.S.3
  • 37
    • 77950613737 scopus 로고    scopus 로고
    • A Hidden Markov Model combining linkage and linkage disequilibrium information for haplotype reconstruction and QTL fine-mapping
    • Druet T, Georges M, (2010) A Hidden Markov Model combining linkage and linkage disequilibrium information for haplotype reconstruction and QTL fine-mapping. Genetics 184: 789-798.
    • (2010) Genetics , vol.184 , pp. 789-798
    • Druet, T.1    Georges, M.2
  • 38
    • 34447316408 scopus 로고    scopus 로고
    • Efficient multilocus association mapping for whole genome association studies using localized haplotype clustering
    • Browning BL, Browning SR, (2007) Efficient multilocus association mapping for whole genome association studies using localized haplotype clustering. Genet Epidemiol 31: 365-375.
    • (2007) Genet Epidemiol , vol.31 , pp. 365-375
    • Browning, B.L.1    Browning, S.R.2
  • 39
    • 0032813698 scopus 로고    scopus 로고
    • Construction and characterization of a porcine P1-derived artificial chromosome (PAC) library covering 3.2 genome equivalents and cytogenetical assignment of six type I and type II loci
    • AI-Bayati HK, Duscher S, Kollers S, Rettenberger G, Fries R, et al. (1999) Construction and characterization of a porcine P1-derived artificial chromosome (PAC) library covering 3.2 genome equivalents and cytogenetical assignment of six type I and type II loci. Mamm Genome 10: 569-572.
    • (1999) Mamm Genome , vol.10 , pp. 569-572
    • AI-Bayati, H.K.1    Duscher, S.2    Kollers, S.3    Rettenberger, G.4    Fries, R.5
  • 40
    • 0032768413 scopus 로고    scopus 로고
    • Construction of a swine BAC library: application to the characterization and mapping of porcine type C endoviral elements
    • Rogel-Gaillard C, Bourgeaux N, Billault A, Vaiman M, Chardon P, (1999) Construction of a swine BAC library: application to the characterization and mapping of porcine type C endoviral elements. Cytogenet Cell Genet 85: 205-211.
    • (1999) Cytogenet Cell Genet , vol.85 , pp. 205-211
    • Rogel-Gaillard, C.1    Bourgeaux, N.2    Billault, A.3    Vaiman, M.4    Chardon, P.5
  • 41
    • 0035007832 scopus 로고    scopus 로고
    • A porcine BAC library with tenfold genome coverage: a resource for physical and genetic map integration
    • Fahrenkrug SC, Rohrer GA, Freking BA, Smith TP, Osoegawa K, et al. (2001) A porcine BAC library with tenfold genome coverage: a resource for physical and genetic map integration. Mamm Genome 12: 472-474.
    • (2001) Mamm Genome , vol.12 , pp. 472-474
    • Fahrenkrug, S.C.1    Rohrer, G.A.2    Freking, B.A.3    Smith, T.P.4    Osoegawa, K.5
  • 42
    • 33748949734 scopus 로고    scopus 로고
    • A five-fold pig bacterial artificial chromosome library: a resource for positional cloning and physical mapping
    • Liu W, Zhang Y, Liu Z, Guo L, Wang X, et al. (2006) A five-fold pig bacterial artificial chromosome library: a resource for positional cloning and physical mapping. Prog Nat Sci 16: 889-892.
    • (2006) Prog Nat Sci , vol.16 , pp. 889-892
    • Liu, W.1    Zhang, Y.2    Liu, Z.3    Guo, L.4    Wang, X.5
  • 43
    • 0142071135 scopus 로고    scopus 로고
    • A method for the absolute quantification of cDNA using real time PCR
    • Whelan JA, Russel NB, Whelan MA (2003) A method for the absolute quantification of cDNA using real time PCR. J Immunol Meth 278, 261-269.
    • (2003) J Immunol Meth , vol.278 , pp. 261-269
    • Whelan, J.A.1    Russel, N.B.2    Whelan, M.A.3
  • 45
    • 0032828561 scopus 로고    scopus 로고
    • Scanning the available dictyostelium discoideum proteome for O-linked GlcNAc glycosylation sites using neural networks
    • Gupta R, Jung E, Gooley AA, Williams KL, Brunak S, et al. (1999) Scanning the available dictyostelium discoideum proteome for O-linked GlcNAc glycosylation sites using neural networks. Glycobiology 9: 1009-1022.
    • (1999) Glycobiology , vol.9 , pp. 1009-1022
    • Gupta, R.1    Jung, E.2    Gooley, A.A.3    Williams, K.L.4    Brunak, S.5
  • 46
    • 0026356891 scopus 로고
    • Predicting coled coils from protein sequences
    • Lupas A, Van Dyke M, Stock J, (1991) Predicting coled coils from protein sequences. Science 252: 1162-1164.
    • (1991) Science , vol.252 , pp. 1162-1164
    • Lupas, A.1    Van Dyke, M.2    Stock, J.3
  • 47
    • 20744437001 scopus 로고    scopus 로고
    • RONN: the bio-basis function neural network technique applied to the dectection of natively disordered regions in proteins
    • Yang ZR, Thomson R, McMeil P, Esnouf RM, (2005) RONN: the bio-basis function neural network technique applied to the dectection of natively disordered regions in proteins. Bioinformatics 21: 3369-3376.
    • (2005) Bioinformatics , vol.21 , pp. 3369-3376
    • Yang, Z.R.1    Thomson, R.2    McMeil, P.3    Esnouf, R.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.