The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis

Journal of Pharmacology and Experimental Therapeutics

Volumn 343, Issue 1, 2012, Pages 106-114

  Schmidt, Nadine ^a,c   Art, Julia ^a   Forsch, Ingrid ^a   Werner, Anke ^a   Erkel, Gerhard ^b   Jung, Mathias ^b   Horke, Sven ^a   Kleinert, Hartmut ^a   Pautz, Andrea ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^c University Medicine Mannheim   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CALGRANULIN A; CATHELICIDIN; COMPLEMENT COMPONENT C5A; CURVULARIN; CYCLOOXYGENASE 2; DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LACTONE DERIVATIVE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; STROMAL CELL DERIVED FACTOR 1; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DRUG TARGETING; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROARRAY ANALYSIS; MONOCYTE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; CELL LINE, TRANSFORMED; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; MICE; MICE, INBRED DBA; MICE, TRANSGENIC; ZEARALENONE;

EID: 84866318096     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.192047     Document Type: Article

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