Increased number of activated T cells in lymphocyte subsets of maltreated children: Data from a pilot study

Journal of Psychosomatic Research

Volumn 73, Issue 4, 2012, Pages 313-318

  Bielas, H ^a   Jud, A ^a   Lips, U ^a   Reichenbach, J ^a   Landolt, M A ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Activated T cells; Adverse childhood experiences; Alterations of the immune system; Child maltreatment; Child protection; Follow up study; Lymphocyte subsets

Indexed keywords

ADOLESCENT; ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; CHILD ABUSE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; FOLLOW UP; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; MALE; PILOT STUDY; PRESCHOOL CHILD; SCHOOL CHILD; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; CHILD; CHILD ABUSE; CHILD, PRESCHOOL; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; PILOT PROJECTS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 84866313421     PISSN: 00223999     EISSN: 18791360     Source Type: Journal    
DOI: 10.1016/j.jpsychores.2012.08.003     Document Type: Article

References (46)

1. Danese A, McEwen BS Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology & Behavior 2012, 106:29-39.
2. Margolin G, Gordis EB The effects of family and community violence on children. Annual Review of Psychology 2000, 51:445-479.
3. Heim C, Newport DJ, Bonsall R, Miller AH, Nemeroff CB Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. The American Journal of Psychiatry 2001, 158:575-581.
4. Cicchetti D, Rogosch FA The impact of child maltreatment and psychopathology on neuroendocrine functioning. Development and Psychopathology 2001, 13:783-804.
5. Pervanidou P Biology of post-traumatic stress disorder in childhood and adolescence. Journal of Neuroendocrinology 2008, 20:632-638.
6. Bugental DB, Martorell GA, Barraza V The hormonal costs of subtle forms of infant maltreatment. Hormones and Behavior 2003, 43:237-244.
7. Kendall-Tackett KA Physiological correlates of childhood abuse: chronic hyperarousal in PTSD, depression, and irritable bowel syndrome. Child Abuse & Neglect 2000, 24:799-810.
8. Ross CA Childhood sexual abuse and psychosomatic symptoms in irritable bowel syndrome. Journal of Child Sexual Abuse 2005, 14:27-38.
9. Fries E, Hesse J, Hellhammer J, Hellhammer DH A new view on hypocortisolism. Psychoneuroendocrinology 2005, 30:1010-1016.
10. Elenkov IJ Glucocorticoids and the Th1/Th2 balance. Annals of the New York Academy of Sciences 2004, 1024:138-146.
11. Dube S.R., Fairweather D., Pearson W.S., Felitti V.J., Anda R.F., Croft J.B. Cumulative childhood stress and autoimmune diseases in adults. Psychosomatic Medicine 2009, 71:243-250.
12. Danese A., Caspi A., Williams B., Ambler A., Sugden K., Mika J., et al. Biological embedding of stress through inflammation processes in childhood. Molecular Psychiatry 2011, 16:244-246.
13. Rooks C, Veledar E, Goldberg J, Bremner JD, Vaccarino V Early trauma and inflammation: role of familial factors in a study of twins. Psychosomatic Medicine 2012, 74:146-152.
14. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:1319-1324.
15. Sommershof A, Aichinger H, Engler H, Adenauer H., Catani C., Boneberg E.M., et al. Substantial reduction of naive and regulatory T cells following traumatic stress. Brain, Behavior, and Immunity 2009, 23:1117-1124.
16. Lemieux A, Coe CL, Carnes M Symptom severity predicts degree of T cell activation in adult women following childhood maltreatment. Brain, Behavior, and Immunity 2008, 22:994-1003.
17. Wilson SN, van der Kolk B, Burbridge J, Fisler R, Kradin R Phenotype of blood lymphocytes in PTSD suggests chronic immune activation. Psychosomatics 1999, 40:222-225.
18. Pace TW, Heim CM A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities. Brain, Behavior, and Immunity 2011, 25:6-13.
19. Boscarino JA Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. Annals of the New York Academy of Sciences 2004, 1032:141-153.
20. Maes M Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2011, 35:664-675.
21. Costantino CM, Spooner E, Ploegh HL, Hafler DA Class II MHC self-antigen presentation in human B and T lymphocytes. PLoS One 2012, 7:e29805.
22. Jud A, Lips U, Landolt MA Characteristics associated with maltreatment types in children referred to a hospital protection team. European Journal of Pediatrics 2010, 169:173-180.
23. Jud A, Lips U, Landolt MA Methodological challenges in following up patients of a hospital child protection team: is there a recruitment bias?. Child and Adolescent Psychiatry and Mental Health 2010, 4:27.
24. Steinberg AM, Brymer MJ, Decker KB, Pynoos RS The University of California at Los Angeles Post-traumatic Stress Disorder Reaction Index. Current Psychiatry Reports 2004, 6:96-100.
25. Scheeringa MS, Zeanah CH, Myers L, Putnam FW Predictive validity in a prospective follow-up of PTSD in preschool children. Journal of the American Academy of Child and Adolescent Psychiatry 2005, 44:899-906.
26. Stiensmeierpelster J, Schurmann M, Urhahne D Inventory of Depression in Children and Adolescents (Dikj) - Usability in Primary Grades. Zeitschrift Fur Entwicklungspsychologie Und Padagogische Psychologie 1991, 23:171-176.
27. Kovacs M The Children's Depression, Inventory (CDI). Psychopharmacology Bulletin 1985, 21:995-998.
28. Largo R.H., Pfister D., Molinari L., Kundu S., Lipp A., Duc G. Significance of prenatal, perinatal and postnatal factors in the development of AGA preterm infants at five to seven years. Developmental Medicine and Child Neurology 1989, 31:440-456.
29. Comans-Bitter W.M., de Groot R., van den Beemd R., Neijens H.J., Hop W.C., Groeneveld K., et al. Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations. The Journal of Pediatrics 1997, 130:388-393.
30. Shearer W.T., Rosenblatt H.M., Gelman R.S., Oyomopito R., Plaeger S., Stiehm E.R., et al. Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study. The Journal of Allergy and Clinical Immunology 2003, 112:973-980.
31. Cohen J A power primer. Psychological Bulletin 1992, 112:155-159.
32. Tabachnick BGFL Using multivariate statistics 1996, HarperCollins, New York. 3rd ed.
33. McCrory E, De Brito SA, Viding E The impact of childhood maltreatment: a review of neurobiological and genetic factors. Frontiers in Psychiatry 2011, 2:48.
34. Boscarino JA, Chang J Higher abnormal leukocyte and lymphocyte counts 20 years after exposure to severe stress: research and clinical implications. Psychosomatic Medicine 1999, 61:378-386.
35. Vidovic A., Vilibic M., Sabioncello A., Gotovac K., Rabatic S., Folnegovic-Smalc V., et al. Circulating lymphocyte subsets, natural killer cell cytotoxicity, and components of hypothalamic-pituitary-adrenal axis in Croatian war veterans with posttraumatic stress disorder: cross-sectional study. Croatian Medical Journal 2007, 48:198-206.
36. Altemus M, Cloitre M, Dhabhar FS Enhanced cellular immune response in women with PTSD related to childhood abuse. The American Journal of Psychiatry 2003, 160:1705-1707.
37. Altemus M, Dhabhar FS, Yang R Immune function in PTSD. Annals of the New York Academy of Sciences 2006, 1071:167-183.
38. Engler H, Bailey MT, Engler A, Sheridan JF Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen. Journal of Neuroimmunology 2004, 148:106-115.
39. Woods AB, Page GG, O'Campo P, Pugh L.C., Ford D., Campbell J.C. The mediation effect of posttraumatic stress disorder symptoms on the relationship of intimate partner violence and IFN-gamma levels. American Journal of Community Psychology 2005, 36:159-175.
40. Kawamura N, Kim Y, Asukai N Suppression of cellular immunity in men with a past history of posttraumatic stress disorder. The American Journal of Psychiatry 2001, 158:484-486.
41. Danese A, Moffitt TE, Pariante CM, Ambler A., Poulton R., Caspi A. Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry 2008, 65:409-415.
42. Yamada H, Nakashima Y, Okazaki K, Mawatari T., Fukushi J., Oyamada A., et al. Preferential accumulation of activated Th1 cells not only in rheumatoid arthritis but also in osteoarthritis joints. The Journal of Rheumatology 2011, 38:1569-1575.
43. Qureshi SU, Pyne JM, Magruder KM, Schulz PE, Kunik ME The link between post-traumatic stress disorder and physical comorbidities: a systematic review. The Psychiatric Quarterly 2009, 80:87-97.
44. von Kanel R, Hepp U, Kraemer B, Traber R., Keel M., Mica L., et al. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. Journal of Psychiatric Research 2007, 41:744-752.
45. Sharpley CF, Agnew LL Cytokines and depression: findings, issues, and treatment implications. Reviews in the Neurosciences 2011, 22:295-302.
46. McGowan PO, Sasaki A, D'Alessio AC, Dymov S., Labonte B., Szyf M., et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience 2009, 12:342-348.