Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells

Diabetology and Metabolic Syndrome

Volumn 4, Issue 1, 2012, Pages

  Hammarstedt, Ann ^a   Graham, Timothy E ^b   Kahn, Barbara B ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adipocyte cell size; Adiponectin; BMI; GLUT4; Insulin sensitivity; RBP4

Indexed keywords

ADIPONECTIN; GLUCOSE; GLUCOSE TRANSPORTER 4; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; MESSENGER RNA;

ADIPOSE TISSUE CELL; ADULT; ARTICLE; BIOPSY; BLOOD SAMPLING; CELL SIZE; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

EID: 84866299574     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-4-42     Document Type: Article

References (37)

1. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Qatanani M, Lazar MA, Genes Dev 2007 21 1443 1455 10.1101/gad.1550907 17575046
2. Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance-is insulin resistance initiated in the adipose tissue? Smith U, Int J Obes Relat Metab Disord 2002 26 897 904 12080441
3. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. Carvalho E, Jansson PA, Axelsen M, Eriksson JW, Huang X, Groop L, Rondinone C, Sjostrom L, Smith U, FASEB J 1999 13 2173 2178 10593864
4. Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport. Carvalho E, Jansson PA, Nagaev I, Wenthzel AM, Smith U, FASEB J 2001 15 1101 1103 11292681
5. A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin. Jansson PA, Pellme F, Hammarstedt A, Sandqvist M, Brekke H, Caidahl K, Forsberg M, Volkmann R, Carvalho E, Funahashi T, et al. FASEB J 2003 17 1434 1440 10.1096/fj.02-1132com 12890697
6. Glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus. Shepherd PR, Kahn BB, N Engl J Med 1999 341 248 257 10.1056/NEJM199907223410406 10413738
7. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Isakson P, Hammarstedt A, Gustafson B, Smith U, Diabetes 2009 58 1550 1557 10.2337/db08-1770 19351711
8. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, Schraw T, Durand JL, Li H, Li G, et al. J Clin Invest 2007 117 2621 2637 10.1172/JCI31021 17717599
9. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB, J Biol Chem 1993 268 22243 22246 8226728
10. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Carvalho E, Kotani K, Peroni OD, Kahn BB, Am J Physiol Endocrinol Metab 2005 289 551 E561 10.1152/ajpendo.00116.2005 15928024
11. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB, Nature 2005 436 356 362 10.1038/nature03711 16034410
12. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH, Smith U, Proc Natl Acad Sci U S A 1997 94 4171 4175 10.1073/pnas.94.8.4171 9108124
13. Thiazolidinediones (PPARgamma agonists) but not PPARalpha agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes. Smith U, Gogg S, Johansson A, Olausson T, Rotter V, Svalstedt B, FASEB J 2001 15 215 220 10.1096/fj.00-0020com 11149909
14. Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study. Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vanttinen M, Stancakova A, Jansson PA, Pellme F, Holst JJ, Kuulasmaa T, et al. Diabetologia 2008 51 502 511 10.1007/s00125-007-0899-2 18080106
15. Antagonistic effects of thiazolidinediones and cytokines in lipotoxicity. Smith U, Hammarstedt A, Biochim Biophys Acta 1801 377 380
16. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM, Mol Cell 1999 3 151 158 10.1016/S1097-2765(00)80306-8 10078198
17. Inflammation and impaired adipogenesis in hypertrophic obesity in man. Gustafson B, Gogg S, Hedjazifar S, Jenndahl L, Hammarstedt A, Smith U, Am J Physiol Endocrinol Metab 2009 297 5 2999 E1003
18. High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator. Sopasakis VR, Sandqvist M, Gustafson B, Hammarstedt A, Schmelz M, Yang X, Jansson PA, Smith U, Obes Res 2004 12 454 460 10.1038/oby.2004.51 15044662
19. Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Trayhurn P, Wang B, Wood IS, Br J Nutr 2008 100 227 235 18397542
20. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Weyer C, Foley JE, Bogardus C, Tataranni PA, Pratley RE, Diabetologia 2000 43 1498 1506 10.1007/s001250051560 11151758
21. Adipocyte size predicts incidence of type 2 diabetes in women. Lonn M, Mehlig K, Bengtsson C, Lissner L, FASEB J 24 326 331
22. Insulin-sensitive obesity. Kloting N, Fasshauer M, Dietrich A, Kovacs P, Schon MR, Kern M, Stumvoll M, Bluher M, Am J Physiol Endocrinol Metab 299 506 E515
23. Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. Arner P, Arner E, Hammarstedt A, Smith U, PLoS One 6 18284
24. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Kloting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schon MR, Stumvoll M, Bluher M, Kahn BB, Cell Metab 2007 6 79 87 10.1016/j.cmet.2007.06.002 17618858
25. Transcriptional and post-translational regulation of adiponectin. Liu M, Liu F, Biochem J 425 41 52
26. Insulin-sensitive obesity. Kloting N, Fasshauer M, Dietrich A, Kovacs P, Schon MR, Kern M, Stumvoll M, Bluher M, Am J Physiol Endocrinol Metab 2010 299 506 E515 10.1152/ajpendo.00586.2009 20570822
27. Adipocyte turnover: relevance to human adipose tissue morphology. Arner E, Westermark PO, Spalding KL, Britton T, Ryden M, Frisen J, Bernard S, Arner P, Diabetes 59 105 109
28. Sex- and depot-dependent differences in adipogenesis in normal-weight humans. Tchoukalova YD, Koutsari C, Votruba SB, Tchkonia T, Giorgadze N, Thomou T, Kirkland JL, Jensen MD, Obesity (Silver Spring) 18 1875 1880
29. Direct effects of sex steroid hormones on adipose tissues and obesity. Mayes JS, Watson GH, Obes Rev 2004 5 197 216 10.1111/j.1467-789X.2004.00152.x 15458395
30. Promotion of human adipocyte precursor replication by 17beta-estradiol in culture. Roncari DA, Van RL, J Clin Invest 1978 62 503 508 10.1172/JCI109153 690182
31. Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance. Manneras-Holm L, Leonhardt H, Kullberg J, Jennische E, Oden A, Holm G, Hellstrom M, Lonn L, Olivecrona G, Stener-Victorin E, Lonn M, J Clin Endocrinol Metab 96 304 311
32. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Liu J, Divoux A, Sun J, Zhang J, Clement K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, et al. Nat Med 2009 15 940 945 10.1038/nm.1994 19633655
33. Obesity is associated with macrophage accumulation in adipose tissue. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr, J Clin Invest 2003 112 1796 1808 14679176
34. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H, J Clin Invest 2003 112 1821 1830 14679177
35. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. Gustafson B, Smith U, J Biol Chem 2006 281 9507 9516 16464856
36. Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Shibata T, Akiyama N, Noda M, Sasai K, Hiraoka M, Int J Radiat Oncol Biol Phys 1998 42 913 916 10.1016/S0360-3016(98)00298-3 9845121
37. Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective. Virtue S, Vidal-Puig A, Biochim Biophys Acta 2010 1801 338 349 10.1016/j.bbalip.2009.12.006 20056169